Katerina Akassoglou, PhD
Dr. Katerina Akassoglou studies mechanisms that control the communication between the brain, immune and vascular systems to design novel therapies for neurologic diseases—and in particular, multiple sclerosis and neurodegenerative diseases.
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Rosemary Akhurst, PhD
TGFβ signaling is important in cancer, vascular, and stem cell biology, as well as tumor drug-resistance and immunotherapy. We study how TGFβ regulates these processes in vivo, and how genetic variation affects TGFβ related diseases and drug outcomes.
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Tamara Alliston, PhD
Our research focuses on the molecular pathways controlling mesenchymal stem cell differentiation, how these pathways coordinate with physical cues to influence normal skeletal tissue, and how they can be harnessed to repair tissue damaged in degenerative skeletal disease.
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Michelle Arkin, PhD
We have two big goals: 1) to develop molecules and proteins that modulate protein-protein interactions in cancer and neurodegenerative diseases, and 2) to work with researchers discover tool compounds and prototype drugs based on their discoveries.
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Diane Barber, PhD
Our research focuses on the regulation of epithelial plasticity, including stem cell differentiation and cancer. We are determining how protein dynamics and cell functions are regulated by intracellular pH (pHi) and actin filament architectures.
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Mary Helen Barcellos-Hoff, PhD
The Barcellos-Hoff laboratory studies breast cancer, mammary radiation carcinogenesis, and mechanisms to augment radiotherapy by 1) determining critical interactions of mammary carcinogenesis 2) identifying targetable TGFβ biology in tumors and the tumor microenvironment.
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Aditi Bhargava, PhD
The overarching goal of our research is to understand the molecular and cellular mechanisms by which corticotropin-releasing factor (CRF) family of neuropeptides and their G-protein coupled receptors mediate effect of stress on physiology.
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Abigail Buchwalter, PhD
We explore how the cell nucleus is built, specialized across cell types, and maintained over time to influence cellular identity. We are uncovering principles of nuclear organization and defining how the nucleus is disrupted by aging and disease.
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Xin Chen, PhD
Our lab studies molecular genetics and signaling pathways during liver cancer growth using both in vitro and in vivo approaches with the goal to develop new therapies to treat this deadly disease.
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Seemay Chou, PhD
Seemay Chou is in the Department of Biochemistry and Biophysics. Her lab investigates the mechanisms by which bacteria interact with specific organisms, including other microbes and tick disease vectors by which they can be transmitted to humans.
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Tejal Desai, PhD
Dr. Desai’s lab focuses in the area of biomedical micro and nanotechnology for therapeutic delivery. She uses micro and nanofabrication-based technologies to create innovative devices for drug delivery, cell and tissue scaffolds, and medical devices.
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Dena Dubal, MD, PhD
Our work focuses on understanding brain resilience in aging and neurodegenerative diseases like Alzheimer’s - from molecular, network, and population perspectives.
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Sophie Dumont, PhD
Our lab is interested in the self-organization and mechanics underlying chromosome segregation at cell division. We aim to uncover the mechanical principles that drive robust and accurate segregation, and how failures arise in disease.
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Hana El Samad, PhD
Our works focuses on understanding how cells regulate their function through feedback control and on designing programmable cellular recognizance and repair circuits that can be broadly deployed for therapeutic and biotechnological applications.
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Joanne Engel, MD, PhD
We are interested in the complex interplay between pathogens, specifically Pseudomonas aerguginosa and Chlamydia trachomatis, and the host epithelial barrier.
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Faranak Fattahi, PhD
We use human pluripotent stem cells to develop models of peripheral nervous system development and function. We utilize these models to define disease mechanisms and identify new therapeutic targets for peripheral neuropathies.
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Susan Fisher, PhD
Dr. Fisher developed approaches for studying the human placenta that have advanced our understanding of how this transient organ functions during normal pregnancy and discovered a key step in implantation and new methods for deriving human embryonic stem cells.
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Ying-Hui Fu, PhD
My research focuses on using human genetics to identify mutations that contribute to neurological conditions and sleep behaviors and then to characterize the corresponding wild-type and mutant proteins.
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Danica Fujimori, PhD
The Fujimori lab investigates fundamental biological mechanisms to understand how misregulation leads to disease. Our focus is on modifications of cellular components by small molecule chemical tags, and the roles of these modifications in biological regulation.
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Jennifer Fung, PhD
We quantitatively analyze what prevents gametes (sperm and egg in mammals, spores in yeast, pollen in plants) from missegregating their chromosomes during meiosis to result in aneuploidy, a leading cause of infertility.
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Kathleen Giacomini, PhD
The Giacomini lab looks at the biological and pharmacological roles of influx transporters in the solute carrier superfamily (SLC). We focus on functional genomic studies of membrane transporters and discovering genetic polymorphisms that underlie differences in drug response.
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Jennifer Grandis, MD
Dr. Grandis’s research focuses on the signal transduction in head and neck squamous cell carcinoma (HNSCC) development and progression with the ultimate goal of targeting key pathways for therapeutic benefit.
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Lea Grinberg, MD, PhD
Dr. Grinberg investigates the mechanisms, spreading, and features of neurodegenerative disease during early clinically silent stages using postmortem human brain tissue, neurons derived from iPSCs, and advanced computing technology.
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Su Guo, PhD
I research the “see-through” zebrafish brain to gain fundamental insights, from molecules to cell types and to networks, for uncovering evolutionarily conserved principles, understanding and treating neurodegenerative and neuropsychiatric diseases.
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Jill Hollenbach, PhD, MPH
Dr. Hollenbach’s research analyzes human leukocyte antigen (HLA) and killer immunoglobulin-like receptor (KIR) immunogenetic systems. She looks at the population genetics, evolution, and influence on health of these genes, as well as software development designed for these data.
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Holly Ingraham, PhD
The Ingraham Lab investigates mammalian sex-differences and how hormone signaling in the brain and in the gut-brain axis affects sex-dependent physiological endpoints in females, especially during aging.
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Roshanak Irannejad, PhD
Our research focuses on understanding the roles of compartmentalized, organelle-based signaling and membrane trafficking as two key steps which allow cells to respond to external cues.
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Isha Jain, PhD
My lab broadly studies Oxygen. We are developing low & high oxygen environments as therapies for metabolic and age-associated conditions. We want to understand states of too much oxygen (e.g. mitochondrial disease) or too little oxygen (e.g. stroke).
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Natalia Jura, PhD
We study cellular communication by investigating structure and function of cellular surface receptor kinases and their cytosolic partners. Our goal is to unveil fundamental principles of signal transduction and advance therapies of diseases driven by abnormal protein phosphorylation.
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Sarah Knox, PhD
My lab explores how organs form and regenerate, specifically emphasizing salivary glands, lacrimal glands, and the pancreas. We are currently working on a clinical trial for head and neck cancer patients whose salivary glands were destroyed during treatments.
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Tanja Kortemme, PhD
Our research aims to invent computational design approaches to engineer biological molecules with new structures and functions, and to interrogate biological systems to reveal mechanisms that bridge the atomistic, molecular, and network scales.
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Deanna Kroetz, PhD
Our lab is focused on understanding the molecular determinants of drug response and toxicity. We identify genetic predictors of drug response in patient populations using state of the art genomic technologies.
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Diana Laird, PhD
I am interested in stem cells, reproduction, and evolution. We focus on 3 questions: are developing germ cells equally likely to produce functional eggs or sperm; how does environment affect germ cell development; and what is the role of germ cells in ovarian and systemic aging?
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Anna Molofsky, MD, PhD
Dr. Anna Molofsky is an Assistant Professor in the Department of Psychiatry. The Molofsky lab investigates the mechanisms of synapse formation during brain development, with a focus on innate immune signals that regulate synapse homeostasis.
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Shaeri Mukherjee, PhD
We use Legionella pneumophila, the causative agent of Legionnaires' disease, as a discovery tool to understand aspects of host-pathogen arms race as well as fundamental mechanisms of host cell biology
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Geeta Narlikar, PhD
Dr. Narlikar studies how genome folding and compartmentalization is regulated to generate the cell types that make up our body. Her lab has pioneered application of sophisticated biophysical approaches to study mechanisms of macromolecules regulating genome organization.
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Melanie Ott, MD, PhD
The Ott Lab studies how viruses interact with host cells. Through these interactions, we hope to gain molecular insight into cellular processes, the viral life cycle and new drug targets. We focus on HIV latency, Zika neuropathogenesis, and human 3D organoids as model systems.
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Georgia Panagiotakos, PhD
Our research aims to understand how neural stem cells integrate signals from their environment to differentiate into specific types of neurons in the developing brain, with an eye towards uncovering mechanisms underlying developmental disorders.
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Rushika Perera, PhD
Our lab studies the function of cellular recycling pathways such as autophagy and lysosome biogenesis in the context of cancer initiation and progression, using a combination of mouse genetics, organelle isolation and proteomics approaches.
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Katie Pollard, PhD
The Pollard lab develops bioinformatics methods for comparative analysis of massive biological datasets, focusing on genomics and other transformative technologies. This enables statistically rigorous quantitative comparisons across species, developmental stages, and conditions.
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Kira Poskanzer, PhD
The Poskanzer lab investigates how neurons and astrocytes function together in the brain, using cellular- and circuit-level multiphoton imaging. Our major questions explore how astrocytes coordinate neuronal activity and how neuronal signals differentially activate astrocytes.
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Melissa Reeves, PhD
The Reeves Lab is interested in tumor heterogeneity, the evolutionary dynamics that create and perpetuate genetic and cellular heterogeneity within tumors, and the impact of this heterogeneity on the anti-tumor immune response.
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Nadia Roan, PhD
The Roan Lab focuses on characterizing tissue lymphocytes including how they sense and respond to microbial pathogens, and their roles in various human diseases using CyTOF and other high-dimensional single-cell analysis technologies.
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Dorit Ron, PhD
Dr. Ron’s lab is interested in elucidating neuroadaptations that occur in the adult brain in response to alcohol use. The long-term goal is to identify novel targets that could be developed as therapeutics to treat alcohol addiction.
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Rada Savic, PhD
We focus on modeling and simulation of exposure-response relationships, disease processes, and new drug therapies, with the aim of improving patient outcomes and treatment effectiveness.
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Licia Selleri, MD PhD
We use organismal models, including chick, mouse, pig, and human embryos, to understand the cellular, genetic, and regulatory mechanisms underlying morphogenesis of the embryonic face and its features in evolution and human congenital disease.
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Marina Sirota, PhD
The Sirota Lab develops integrative computational methods and applies these approaches to disease diagnostics and therapeutics. We are interested in leveraging and integrating different types of omics and clinical data to understand the immune system’s role in disease.
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Thea Tlsty, PhD
Dr. Tlsty is a molecular pathologist studying genetic, epigenetic, and functional changes in the microenvironment in the earliest steps of cancer. This provides novel insights for early detection, disease stratification and new approaches for prevention and treatment of cancer.
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Susan Voglmaier, MD, PhD
We use and develop optical tools to image the dynamics of synaptic vesicle components. My lab has developed optical reporters of calcium dynamics and synaptic vesicle recycling based on vesicular transporters involved both in synaptic vesicle filling and trafficking.
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Rong Wang, PhD
My lab studies angiogenesis, focusing on molecular and hemodynamic mechanisms of arteriovenous programming during development and aging. We use preclinical mouse models and live imaging approaches to identify drug targets and develop therapeutic strategies for unmet vascular diseases.
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Lauren Weiss, PhD
We study the genetics of autism and related disorders, with a particular interest in complex mechanisms like gene-gene, gene-environment, and gene-sex interaction. We use approaches from computational analysis to human induced pluripotent stem cells.
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Allison Xu, PhD
Research in Allison Xu’s lab focuses on understanding how the brain senses and integrates peripheral hormones and nutritional signals, and how CNS neurons regulate feeding, energy expenditure, systemic glucose and lipid metabolism.
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