Licia Selleri, PhD, MD

Professor
Orofacial Sciences
[email protected]
+1 415 502-2096

UCSF School of Medicine
Department of Anatomy
Institute of Human Genetics
Eli and Edythe Broad Center of Regeneration Medicine & Stem Cell Research

Genetic and regulatory control of morphogenesis in embryonic development, evolution, and disease

The laboratory studies the genetic and regulatory basis of how elaborately patterned tissues form during embryonic development and evolution. The laboratory combines different genetic approaches, using the mouse as a model, to understand the mechanisms underpinning basic developmental processes related to cranial and appendicular morphogenesis. They discovered that homeodomain-containing transcription factors of the Pbx family, also known as Hox-cofactors, are critical developmental regulators through the transcriptional control of target genes within tissue-specific regulatory networks. The lab uses genetically-engineered and ethylnitrosourea (ENU)-mutagenized mouse lines. Recently they utilize additional animal models, such as jerboas and primates, with the ultimate goal to identify novel genes and regulatory networks underlying morphogenesis of embryonic structures, morphological variation, and evolution. Focus is also given to how perturbation of these regulatory networks can result in human congenital disease.

Publications: 

A common cis-regulatory variant impacts normal-range and disease-associated human facial shape through regulation of PKDCC during chondrogenesis.

eLife

Mohammed J, Arora N, Matthews HS, Hansen K, Bader M, Walsh S, Shaffer JR, Weinberg SM, Swigut T, Claes P, Selleri L, Wysocka J

Conserved enhancers control notochord expression of vertebrate Brachyury.

Nature communications

Kemmler CL, Smolikova J, Moran HR, Mannion BJ, Knapp D, Lim F, Czarkwiani A, Hermosilla Aguayo V, Rapp V, Fitch OE, Bötschi S, Selleri L, Farley E, Braasch I, Yun M, Visel A, Osterwalder M, Mosimann C, Kozmik Z, Burger A

ESCRT-dependent control of craniofacial morphogenesis with concomitant perturbation of NOTCH signaling.

Developmental biology

Hermosilla Aguayo V, Martin P, Tian N, Zheng J, Aho R, Losa M, Selleri L

A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2.

Nature communications

Losa M, Barozzi I, Osterwalder M, Hermosilla-Aguayo V, Morabito A, Chacón BH, Zarrineh P, Girdziusaite A, Benazet JD, Zhu J, Mackem S, Capellini TD, Dickel D, Bobola N, Zuniga A, Visel A, Zeller R, Selleri L

Conserved enhancer logic controls the notochord expression of vertebrate Brachyury.

bioRxiv : the preprint server for biology

Kemmler CL, Smolikova J, Moran HR, Mannion BJ, Knapp D, Lim F, Czarkwiani A, Aguayo VH, Rapp V, Fitch OE, Bötschi S, Selleri L, Farley E, Braasch I, Yun M, Visel A, Osterwalder M, Mosimann C, Kozmik Z, Burger A

Generation of Schwann cell derived melanocytes from hPSCs identifies pro-metastatic factors in melanoma.

bioRxiv : the preprint server for biology

Samuel RM, Navickas A, Maynard A, Gaylord EA, Garcia K, Bhat S, Majd H, Richter MN, Elder N, Le D, Nguyen P, Shibata B, Llabata ML, Selleri L, Laird DJ, Darmanis S, Goodarzi H, Fattahi F

The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo.

The EMBO journal

Feldhahn N, Ferretti E, Robbiani DF, Callen E, Deroubaix S, Selleri L, Nussenzweig A, Nussenzweig MC

Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder.

Cell stem cell

Long HK, Osterwalder M, Welsh IC, Hansen K, Davies JOJ, Liu YE, Koska M, Adams AT, Aho R, Arora N, Ikeda K, Williams RM, Sauka-Spengler T, Porteus MH, Mohun T, Dickel DE, Swigut T, Hughes JR, Higgs DR, Visel A, Selleri L, Wysocka J

FaceBase 3: analytical tools and FAIR resources for craniofacial and dental research.

Development (Cambridge, England)

Samuels BD, Aho R, Brinkley JF, Bugacov A, Feingold E, Fisher S, Gonzalez-Reiche AS, Hacia JG, Hallgrimsson B, Hansen K, Harris MP, Ho TV, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Leslie EJ, Li H, Liao EC, Long H, Lu N, Maas RL, Marazita ML, Mohammed J, Prescott S, Schuler R, Selleri L, Spritz RA, Swigut T, van Bakel H, Visel A, Welsh I, Williams C, Williams TJ, Wysocka J, Yuan Y, Chai Y

A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation.

Developmental cell

Cozzitorto C, Mueller L, Ruzittu S, Mah N, Willnow D, Darrigrand JF, Wilson H, Khosravinia D, Mahmoud AA, Risolino M, Selleri L, Spagnoli FM

Ubiquitous overexpression of CXCL12 confers radiation protection and enhances mobilization of hematopoietic stem and progenitor cells.

Stem cells (Dayton, Ohio)

Rajendiran S, Smith-Berdan S, Kunz L, Risolino M, Selleri L, Schroeder T, Forsberg EC

Functional characterisation of a novel PBX1 de novo missense variant identified in a patient with syndromic congenital heart disease.

Human molecular genetics

Alankarage D, Szot JO, Pachter N, Slavotinek A, Selleri L, Shieh JT, Winlaw D, Giannoulatou E, Chapman G, Dunwoodie SL

Genetics of scapula and pelvis development: An evolutionary perspective.

Current topics in developmental biology

Young M, Selleri L, Capellini TD

Incomplete penetrance for isolated congenital asplenia in humans with mutations in translated and untranslated RPSA exons.

Proceedings of the National Academy of Sciences of the United States of America

Bolze A, Boisson B, Bosch B, Antipenko A, Bouaziz M, Sackstein P, Chaker-Margot M, Barlogis V, Briggs T, Colino E, Elmore AC, Fischer A, Genel F, Hewlett A, Jedidi M, Kelecic J, Krüger R, Ku CL, Kumararatne D, Lefevre-Utile A, Loughlin S, Mahlaoui N, Markus S, Garcia JM, Nizon M, Oleastro M, Pac M, Picard C, Pollard AJ, Rodriguez-Gallego C, Thomas C, Von Bernuth H, Worth A, Meyts I, Risolino M, Selleri L, Puel A, Klinge S, Abel L, Casanova JL

Pbx loss in cranial neural crest, unlike in epithelium, results in cleft palate only and a broader midface.

Journal of anatomy

Welsh IC, Hart J, Brown JM, Hansen K, Rocha Marques M, Aho RJ, Grishina I, Hurtado R, Herzlinger D, Ferretti E, Garcia-Garcia MJ, Selleri L

Face morphogenesis is promoted by Pbx-dependent EMT via regulation of Snail1 during frontonasal prominence fusion.

Development (Cambridge, England)

Losa M, Risolino M, Li B, Hart J, Quintana L, Grishina I, Yang H, Choi IF, Lewicki P, Khan S, Aho R, Feenstra J, Vincent CT, Brown AMC, Ferretti E, Williams T, Selleri L

PBX transcription factors drive pulmonary vascular adaptation to birth.

The Journal of clinical investigation

McCulley DJ, Wienhold MD, Hines EA, Hacker TA, Rogers A, Pewowaruk RJ, Zewdu R, Chesler NC, Selleri L, Sun X

De novo, deleterious sequence variants that alter the transcriptional activity of the homeoprotein PBX1 are associated with intellectual disability and pleiotropic developmental defects.

Human molecular genetics

Slavotinek A, Risolino M, Losa M, Cho MT, Monaghan KG, Schneidman-Duhovny D, Parisotto S, Herkert JC, Stegmann APA, Miller K, Shur N, Chui J, Muller E, DeBrosse S, Szot JO, Chapman G, Pachter NS, Winlaw DS, Mendelsohn BA, Dalton J, Sarafoglou K, Karachunski PI, Lewis JM, Pedro H, Dunwoodie SL, Selleri L, Shieh J

Toward Microsurgical Correction of Cleft Lip Ex Utero through Restoration of Craniofacial Developmental Programs.

Plastic and reconstructive surgery

Dong X, Landford WN, Hart J, Risolino M, Kaymakcalan O, Jin J, Toyoda Y, Ferretti E, Selleri L, Spector JA

A Hox-Embedded Long Noncoding RNA: Is It All Hot Air?

PLoS genetics

Selleri L, Bartolomei MS, Bickmore WA, He L, Stubbs L, Reik W, Barsh GS

Ovarian Cancer Chemoresistance Relies on the Stem Cell Reprogramming Factor PBX1.

Cancer research

Jung JG, Shih IM, Park JT, Gerry E, Kim TH, Ayhan A, Handschuh K, Davidson B, Fader AN, Selleri L, Wang TL

Parallel Pbx-Dependent Pathways Govern the Coalescence and Fate of Motor Columns.

Neuron

Hanley O, Zewdu R, Cohen LJ, Jung H, Lacombe J, Philippidou P, Lee DH, Selleri L, Dasen JS

A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease.

The EMBO journal

Villaescusa JC, Li B, Toledo EM, Rivetti di Val Cervo P, Yang S, Stott SR, Kaiser K, Islam S, Gyllborg D, Laguna-Goya R, Landreh M, Lönnerberg P, Falk A, Bergman T, Barker RA, Linnarsson S, Selleri L, Arenas E

The FaceBase Consortium: a comprehensive resource for craniofacial researchers.

Development (Cambridge, England)

Brinkley JF, Fisher S, Harris MP, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Maas RL, Marazita ML, Selleri L, Spritz RA, van Bakel H, Visel A, Williams TJ, Wysocka J, Chai Y

Pbx1 is required for adult subventricular zone neurogenesis.

Development (Cambridge, England)

Grebbin BM, Hau AC, Groß A, Anders-Maurer M, Schramm J, Koss M, Wille C, Mittelbronn M, Selleri L, Schulte D

Spleen hypoplasia leads to abnormal stress hematopoiesis in mice with loss of Pbx homeoproteins in splenic mesenchyme.

Journal of anatomy

Zewdu R, Risolino M, Barbulescu A, Ramalingam P, Butler JM, Selleri L

Pbx Regulates Patterning of the Cerebral Cortex in Progenitors and Postmitotic Neurons.

Neuron

Golonzhka O, Nord A, Tang PLF, Lindtner S, Ypsilanti AR, Ferretti E, Visel A, Selleri L, Rubenstein JLR

Enhancer divergence and cis-regulatory evolution in the human and chimp neural crest.

Cell

Prescott SL, Srinivasan R, Marchetto MC, Grishina I, Narvaiza I, Selleri L, Gage FH, Swigut T, Wysocka J

Pbx1-dependent control of VMC differentiation kinetics underlies gross renal vascular patterning.

Development (Cambridge, England)

Hurtado R, Zewdu R, Mtui J, Liang C, Aho R, Kurylo C, Selleri L, Herzlinger D

An allelic series of miR-17 ~ 92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron.

Nature genetics

Han YC, Vidigal JA, Mu P, Yao E, Singh I, González AJ, Concepcion CP, Bonetti C, Ogrodowski P, Carver B, Selleri L, Betel D, Leslie C, Ventura A

Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution.

Science (New York, N.Y.)

Vierstra J, Rynes E, Sandstrom R, Zhang M, Canfield T, Hansen RS, Stehling-Sun S, Sabo PJ, Byron R, Humbert R, Thurman RE, Johnson AK, Vong S, Lee K, Bates D, Neri F, Diegel M, Giste E, Haugen E, Dunn D, Wilken MS, Josefowicz S, Samstein R, Chang KH, Eichler EE, De Bruijn M, Reh TA, Skoultchi A, Rudensky A, Orkin SH, Papayannopoulou T, Treuting PM, Selleri L, Kaul R, Groudine M, Bender MA, Stamatoyannopoulos JA

A comparative encyclopedia of DNA elements in the mouse genome.

Nature

Yue F, Cheng Y, Breschi A, Vierstra J, Wu W, Ryba T, Sandstrom R, Ma Z, Davis C, Pope BD, Shen Y, Pervouchine DD, Djebali S, Thurman RE, Kaul R, Rynes E, Kirilusha A, Marinov GK, Williams BA, Trout D, Amrhein H, Fisher-Aylor K, Antoshechkin I, DeSalvo G, See LH, Fastuca M, Drenkow J, Zaleski C, Dobin A, Prieto P, Lagarde J, Bussotti G, Tanzer A, Denas O, Li K, Bender MA, Zhang M, Byron R, Groudine MT, McCleary D, Pham L, Ye Z, Kuan S, Edsall L, Wu YC, Rasmussen MD, Bansal MS, Kellis M, Keller CA, Morrissey CS, Mishra T, Jain D, Dogan N, Harris RS, Cayting P, Kawli T, Boyle AP, Euskirchen G, Kundaje A, Lin S, Lin Y, Jansen C, Malladi VS, Cline MS, Erickson DT, Kirkup VM, Learned K, Sloan CA, Rosenbloom KR, Lacerda de Sousa B, Beal K, Pignatelli M, Flicek P, Lian J, Kahveci T, Lee D, Kent WJ, Ramalho Santos M, Herrero J, Notredame C, Johnson A, Vong S, Lee K, Bates D, Neri F, Diegel M, Canfield T, Sabo PJ, Wilken MS, Reh TA, Giste E, Shafer A, Kutyavin T, Haugen E, Dunn D, Reynolds AP, Neph S, Humbert R, Hansen RS, De Bruijn M, Selleri L, Rudensky A, Josefowicz S, Samstein R, Eichler EE, Orkin SH, Levasseur D, Papayannopoulou T, Chang KH, Skoultchi A, Gosh S, Disteche C, Treuting P, Wang Y, Weiss MJ, Blobel GA, Cao X, Zhong S, Wang T, Good PJ, Lowdon RF, Adams LB, Zhou XQ, Pazin MJ, Feingold EA, Wold B, Taylor J, Mortazavi A, Weissman SM, Stamatoyannopoulos JA, Snyder MP, Guigo R, Gingeras TR, Gilbert DM, Hardison RC, Beer MA, Ren B

Principles of regulatory information conservation between mouse and human.

Nature

Cheng Y, Ma Z, Kim BH, Wu W, Cayting P, Boyle AP, Sundaram V, Xing X, Dogan N, Li J, Euskirchen G, Lin S, Lin Y, Visel A, Kawli T, Yang X, Patacsil D, Keller CA, Giardine B, Kundaje A, Wang T, Pennacchio LA, Weng Z, Hardison RC, Snyder MP

ESCRT-II/Vps25 constrains digit number by endosome-mediated selective modulation of FGF-SHH signaling.

Cell reports

Handschuh K, Feenstra J, Koss M, Ferretti E, Risolino M, Zewdu R, Sahai MA, Bénazet JD, Peng XP, Depew MJ, Quintana L, Sharpe J, Wang B, Alcorn H, Rivi R, Butcher S, Manak JR, Vaccari T, Weinstein H, Anderson KV, Lacy E, Selleri L

Pbx1 activates Fgf10 in the mesenchyme of developing lungs.

Genesis (New York, N.Y. : 2000)

Li W, Lin CY, Shang C, Han P, Xiong Y, Lin CJ, Yang J, Selleri L, Chang CP

ADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes.

Molecular and cellular biology

Hall KC, Hill D, Otero M, Plumb DA, Froemel D, Dragomir CL, Maretzky T, Boskey A, Crawford HC, Selleri L, Goldring MB, Blobel CP

Ribosomal protein SA haploinsufficiency in humans with isolated congenital asplenia.

Science (New York, N.Y.)

Bolze A, Mahlaoui N, Byun M, Turner B, Trede N, Ellis SR, Abhyankar A, Itan Y, Patin E, Brebner S, Sackstein P, Puel A, Picard C, Abel L, Quintana-Murci L, Faust SN, Williams AP, Baretto R, Duddridge M, Kini U, Pollard AJ, Gaud C, Frange P, Orbach D, Emile JF, Stephan JL, Sorensen R, Plebani A, Hammarstrom L, Conley ME, Selleri L, Casanova JL

The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo.

The EMBO journal

Feldhahn N, Ferretti E, Robbiani DF, Callen E, Deroubaix S, Selleri L, Nussenzweig A, Nussenzweig MC

Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module.

Developmental cell

Koss M, Bolze A, Brendolan A, Saggese M, Capellini TD, Bojilova E, Boisson B, Prall OW, Elliott DA, Solloway M, Lenti E, Hidaka C, Chang CP, Mahlaoui N, Harvey RP, Casanova JL, Selleri L

A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis.

Developmental cell

Ferretti E, Li B, Zewdu R, Wells V, Hebert JM, Karner C, Anderson MJ, Williams T, Dixon J, Dixon MJ, Depew MJ, Selleri L

Epigenetic regulation of early osteogenesis and mineralized tissue formation by a HOXA10-PBX1-associated complex.

Cells, tissues, organs

Gordon JA, Hassan MQ, Koss M, Montecino M, Selleri L, van Wijnen AJ, Stein JL, Stein GS, Lian JB

Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentation.

Developmental cell

Vitobello A, Ferretti E, Lampe X, Vilain N, Ducret S, Ori M, Spetz JF, Selleri L, Rijli FM

Control of pelvic girdle development by genes of the Pbx family and Emx2.

Developmental dynamics : an official publication of the American Association of Anatomists

Capellini TD, Handschuh K, Quintana L, Ferretti E, Di Giacomo G, Fantini S, Vaccari G, Clarke SL, Wenger AM, Bejerano G, Sharpe J, Zappavigna V, Selleri L

Pbx homeodomain proteins: TALEnted regulators of limb patterning and outgrowth.

Developmental dynamics : an official publication of the American Association of Anatomists

Capellini TD, Zappavigna V, Selleri L

Scapula development is governed by genetic interactions of Pbx1 with its family members and with Emx2 via their cooperative control of Alx1.

Development (Cambridge, England)

Capellini TD, Vaccari G, Ferretti E, Fantini S, He M, Pellegrini M, Quintana L, Di Giacomo G, Sharpe J, Selleri L, Zappavigna V

Ectopic Meis1 expression in the mouse limb bud alters P-D patterning in a Pbx1-independent manner.

The International journal of developmental biology

Mercader N, Selleri L, Criado LM, Pallares P, Parras C, Cleary ML, Torres M

Conservation of notochord gene expression across chordates: insights from the Leprecan gene family.

Genesis (New York, N.Y. : 2000)

Capellini TD, Dunn MP, Passamaneck YJ, Selleri L, Di Gregorio A

Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease.

Circulation research

Stankunas K, Shang C, Twu KY, Kao SC, Jenkins NA, Copeland NG, Sanyal M, Selleri L, Cleary ML, Chang CP

Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome.

Developmental biology

Capellini TD, Zewdu R, Di Giacomo G, Asciutti S, Kugler JE, Di Gregorio A, Selleri L

Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1.

Immunity

Chung EY, Liu J, Homma Y, Zhang Y, Brendolan A, Saggese M, Han J, Silverstein R, Selleri L, Ma X

Cooperation between p27 and p107 during endochondral ossification suggests a genetic pathway controlled by p27 and p130.

Molecular and cellular biology

Yeh N, Miller JP, Gaur T, Capellini TD, Nikolich-Zugich J, de la Hoz C, Selleri L, Bromage TG, van Wijnen AJ, Stein GS, Lian JB, Vidal A, Koff A

Development and function of the mammalian spleen.

BioEssays : news and reviews in molecular, cellular and developmental biology

Brendolan A, Rosado MM, Carsetti R, Selleri L, Dear TN

B-cell development fails in the absence of the Pbx1 proto-oncogene.

Blood

Sanyal M, Tung JW, Karsunky H, Zeng H, Selleri L, Weissman IL, Herzenberg LA, Cleary ML

Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype.

Molecular and cellular biology

Ferretti E, Villaescusa JC, Di Rosa P, Fernandez-Diaz LC, Longobardi E, Mazzieri R, Miccio A, Micali N, Selleri L, Ferrari G, Blasi F

Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development.

Developmental biology

Zhang X, Rowan S, Yue Y, Heaney S, Pan Y, Brendolan A, Selleri L, Maas RL

Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression.

Development (Cambridge, England)

Capellini TD, Di Giacomo G, Salsi V, Brendolan A, Ferretti E, Srivastava D, Zappavigna V, Selleri L

Hox cofactors in vertebrate development.

Developmental biology

Moens CB, Selleri L

Spatio-temporal expression of Pbx3 during mouse organogenesis.

Gene expression patterns : GEP

Di Giacomo G, Koss M, Capellini TD, Brendolan A, Pöpperl H, Selleri L

A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny.

Development (Cambridge, England)

Brendolan A, Ferretti E, Salsi V, Moses K, Quaggin S, Blasi F, Cleary ML, Selleri L

Abnormalities of caudal pharyngeal pouch development in Pbx1 knockout mice mimic loss of Hox3 paralogs.

Developmental biology

Manley NR, Selleri L, Brendolan A, Gordon J, Cleary ML

Pbx3 deficiency results in central hypoventilation.

The American journal of pathology

Rhee JW, Arata A, Selleri L, Jacobs Y, Arata S, Onimaru H, Cleary ML

The TALE homeodomain protein Pbx2 is not essential for development and long-term survival.

Molecular and cellular biology

Selleri L, DiMartino J, van Deursen J, Brendolan A, Sanyal M, Boon E, Capellini T, Smith KS, Rhee J, Pöpperl H, Grosveld G, Cleary ML

Pbx1 is essential for adrenal development and urogenital differentiation.

Genesis (New York, N.Y. : 2000)

Schnabel CA, Selleri L, Cleary ML

Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus.

Nature genetics

Kim SK, Selleri L, Lee JS, Zhang AY, Gu X, Jacobs Y, Cleary ML

Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation.

Development (Cambridge, England)

Selleri L, Depew MJ, Jacobs Y, Chanda SK, Tsang KY, Cheah KS, Rubenstein JL, O'Gorman S, Cleary ML

The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver.

Blood

DiMartino JF, Selleri L, Traver D, Firpo MT, Rhee J, Warnke R, O'Gorman S, Weissman IL, Cleary ML

Expression of Pbx1b during mammalian organogenesis.

Mechanisms of development

Schnabel CA, Selleri L, Jacobs Y, Warnke R, Cleary ML

Molecular cytogenetics localizes two new breakpoints on 11q23.3 and 21q11.2 in myelodysplastic syndrome with t(11;21) translocation.

Genes, chromosomes & cancer

Wlodarska I, Selleri L, La Starza R, Paternotte C, Evans GA, Boogaerts M, Van den Berghe H, Mecucci C

Organization and regulatory aspects of the human intestinal mucin gene (MUC2) locus.

The Journal of biological chemistry

Velcich A, Palumbo L, Selleri L, Evans G, Augenlicht L

De novo 46,XX, dir dup (11)(q133.3-->q14.2) in a patient with mental retardation, congenital cardiopathy and thrombopenia.

Clinical genetics

Legius E, Wlodarska I, Selleri L, Evans GA, Wu R, Smet G, Fryns JP

An STS content map of human chromosome 11: localization of 910 YAC clones and 109 islands.

Genomics

Quackenbush J, Davies C, Bailis JM, Khristich JV, Diggle K, Marchuck Y, Tobin J, Clark SP, Rodkins A, Marcano S

A novel L23-related gene 40 kb downstream of the imprinted H19 gene is biallelically expressed in mid-fetal and adult human tissues.

Human molecular genetics

Tsang P, Gilles F, Yuan L, Kuo YH, Lupu F, Samara G, Moosikasuwan J, Goye A, Zelenetz AD, Selleri L

Translocation (11;15)(q23;q14) in three patients with acute non-lymphoblastic leukemia (ANLL): clinical, cytogenetic and molecular studies.

Leukemia

Hernández JM, Mecucci C, Beverloo HB, Selleri L, Wlodarska I, Stul M, Michaux L, Verhoef G, Van Orshoven A, Cassiman JJ

High-resolution physical mapping of a 250-kb region of human chromosome 11q24 by genomic sequence sampling (GSS).

Genomics

Selleri L, Smith MW, Holmsen AL, Romo AJ, Thomas SD, Paternotte C, Romberg LC, Wei YH, Evans GA

Spontaneous loss of Ph chromosome with maintenance of clonal hemopoiesis in an untreated patient with myeloproliferative disease and a long survival.

Genes, chromosomes & cancer

Luppi M, Morselli M, Emilia G, Temperani P, Marasca R, Barozzi P, Selleri L, Torelli G

Cloning of the entire FLI1 gene, disrupted by the Ewing's sarcoma translocation breakpoint on 11q24, in a yeast artificial chromosome.

Cytogenetics and cell genetics

Selleri L, Giovannini M, Romo A, Zucman J, Delattre O, Thomas G, Evans GA

A sequence-tagged site map of human chromosome 11.

Genomics

Smith MW, Clark SP, Hutchinson JS, Wei YH, Churukian AC, Daniels LB, Diggle KL, Gen MW, Romo AJ, Lin Y

A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias.

Nature genetics

Djabali M, Selleri L, Parry P, Bower M, Young B, Evans GA

Localization of the human oncostatin M gene (OSM) to chromosome 22q12, distal to the Ewing's sarcoma breakpoint.

Cytogenetics and cell genetics

Giovannini M, Selleri L, Hermanson GG, Evans GA

Tandem linkage of genes coding for leukemia inhibitory factor (LIF) and oncostatin M (OSM) on human chromosome 22.

Cytogenetics and cell genetics

Giovannini M, Djabali M, McElligott D, Selleri L, Evans GA

Structure and linkage of the D2 dopamine receptor and neural cell adhesion molecule genes on human chromosome 11q23.

Genomics

Eubanks JH, Djabali M, Selleri L, Grandy DK, Civelli O, McElligott DL, Evans GA

Interphase cytogenetics for the detection of the t(11;22)(q24;q12) in small round cell tumors.

The Journal of clinical investigation

Giovannini M, Selleri L, Biegel JA, Scotlandi K, Emanuel BS, Evans GA

A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias.

Nature genetics

Djabali M, Selleri L, Parry P, Bower M, Young BD, Evans GA

Detection and characterization of "chimeric" yeast artificial chromosome clones by fluorescent in situ suppression hybridization.

Genomics

Selleri L, Eubanks JH, Giovannini M, Hermanson GG, Romo A, Djabali M, Maurer S, McElligott DL, Smith MW, Evans GA

Serum autoantibodies and the diagnosis of type-1 autoimmune hepatitis in Italy: a reappraisal at the light of hepatitis C virus infection.

Gut

Cassani F, Muratori L, Manotti P, Lenzi M, Fusconi M, Ballardini G, Selleri L, Volta U, Zauli D, Miniero R

Dek-can rearrangement in translocation (6;9)(p23;q34).

Leukemia

Soekarman D, von Lindern M, van der Plas DC, Selleri L, Bartram CR, Martiat P, Culligan D, Padua RA, Hasper-Voogt KP, Hagemeijer A

Cosmid linking clones localized to the long arm of human chromosome 11.

Genomics

Hermanson GG, Lichter P, Selleri L, Ward DC, Evans GA

Human herpesvirus-6 in human lymphomas: identification of specific sequences in Hodgkin's lymphomas by polymerase chain reaction.

Blood

Torelli G, Marasca R, Luppi M, Selleri L, Ferrari S, Narni F, Mariano MT, Federico M, Ceccherini-Nelli L, Bendinelli M

Chromosomal in situ hybridization using yeast artificial chromosomes.

Genetic analysis, techniques and applications

Selleri L, Hermanson GG, Eubanks JH, Evans GA

Molecular localization of the t(11;22)(q24;q12) translocation of Ewing sarcoma by chromosomal in situ suppression hybridization.

Proceedings of the National Academy of Sciences of the United States of America

Selleri L, Hermanson GG, Eubanks JH, Lewis KA, Evans GA

Sinus histiocytosis with massive lymphadenopathy: immunological, cytogenetic and molecular studies.

Blut

Sacchi S, Artusi T, Selleri L, Temperani P, Zucchini P, Vecchi A, Emilia G, Torelli U

Ratios between the abundance of messenger RNA and the corresponding protein of two growth-related genes, c-myc and vimentin, in leukemia blast cells.

Cancer research

Ferrari S, Tagliafico E, D'Incá M, Ceccherelli G, Manfredini R, Selleri L, Donelli A, Sacchi S, Torelli G, Torelli U

[Mitochondrial DNA deletion in a case of progressive ophthalmoplegia].

Medicina (Florence, Italy)

Luppi M, Marasca R, Sola P, Corradi M, Fancinelli M, Montorsi M, Manfredini R, Selleri L

Chronic myelogenous leukemia with typical clinical and morphological features can be Philadelphia chromosome negative and "bcr negative".

Hematologic pathology

Selleri L, Emilia G, Luppi M, Temperani P, Zucchini P, Tagliafico E, Artusi T, Sarti M, Donelli A, Castoldi GL

Extramedullary pleural blast crisis in chronic myelogenous leukemia: cytogenetic and molecular study.

Acta haematologica

Sacchi S, Temperani P, Selleri L, Zucchini P, Morselli S, Vecchi A, Longo R, Torelli G, Emilia G, Torelli U

[Identification of human herpesvirus HHV-6 sequence in a case of Hodgkin's disease by polymerase chain reaction].

Medicina (Florence, Italy)

Marasca R, Luppi M, Montorsi M, Fancinelli M, Sabbatini R, Mariano MT, Selleri L

Serum antibodies to thymus epithelial cells in non-A, non-B and cryptogenic chronic liver disease.

Liver

Cassani F, Tremolada F, Bianchi FB, Baffoni L, Selleri L, Benvegnu L, Craxi A, Realdi G, Zauli D, Pisi E

Philadelphia-positive chronic myelogenous leukemia with typical bcr/abl molecular features and atypical, prolonged survival.

Leukemia

Selleri L, Emilia G, Temperani P, Grassilli E, Zucchini P, Tagliafico E, Bonati A, Venezia L, Ferrari S, Torelli U

Expression of the myeloperoxidase gene in acute and chronic myeloid leukemias: relationship to the expression of cell cycle-related genes.

Leukemia

Ferrari S, Tagliafico E, Ceccherelli G, Selleri L, Calabretta B, Donelli A, Temperani P, Sarti M, Sacchi S, Emilia G

Cytogenetic and molecular studies in primary myelofibrosis.

Cancer genetics and cytogenetics

Emilia G, Temperani P, Ferrari S, Zucchini P, Tagliafico E, Selleri L, Torelli G, Artusi T, Torelli U

Isodicentric X chromosome in myeloproliferative disorders.

Acta haematologica

Temperani P, Zucchini P, Emilia G, Sacchi S, Selleri L, Torelli U

[Polymerase chain reaction for the diagnostic identification of HIV infection].

Medicina (Florence, Italy)

Selleri L, Grassilli E, Tagliafico E, Corradi M, Luppi M, Ceccherelli G, Borghi V

Expression of oncogenes and cell cycle related genes in acute and chronic leukemias.

Leukemia

Ferrari S, Calabretta B, Selleri L, Ceccherelli G, Torelli G, Torelli U

[Possible correlations between proliferation and differentiation of blast cells in acute promyelocytic leukemia: a molecular study].

Medicina (Florence, Italy)

Tagliafico E, Manfredini R, Selleri L, Zucchini P, Ceccherelli G

bcr-abl oncogene activation in Philadelphia chromosome-positive acute lymphoblastic leukemia.

Leukemia

Hermans A, Gow J, Selleri L, von Lindern M, Hagemeijer A, Wiedemann LM, Grosveld G

Myeloperoxidase gene expression in blast cells with a lymphoid phenotype in cases of acute lymphoblastic leukemia.

Blood

Ferrari S, Mariano MT, Tagliafico E, Sarti M, Ceccherelli G, Selleri L, Merli F, Narni F, Donelli A, Torelli G

Prognostic significance of "short-term" effects of chemotherapy on MYC and histone H3 mRNA levels in acute leukemia patients.

Proceedings of the National Academy of Sciences of the United States of America

Venturelli D, Lange B, Narni F, Selleri L, Mariano MT, Torelli U, Gewirtz AM, Calabretta B

Philadelphia-positive chronic myeloid leukemia with a chromosome 22 breakpoint outside the breakpoint cluster region.

Blood

Selleri L, Narni F, Emilia G, Colò A, Zucchini P, Venturelli D, Donelli A, Torelli U, Torelli G

Expression of c-myb protooncogene and other cell cycle-related genes in normal and neoplastic human colonic mucosa.

Cancer research

Torelli G, Venturelli D, Coló A, Zanni C, Selleri L, Moretti L, Calabretta B, Torelli U

Establishment and characterization of a human IgA-kappa-secreting plasma cell line (MT3).

International journal of cancer

Donelli A, Narni F, Tabilio A, Emilia G, Selleri L, Colo A, Zucchini P, Montagnani G, Torelli G, Torelli U

Immunoglobulin and T-cell receptor beta chain gene rearrangements as lineage markers in human leukemias: a study of 78 cases.

Haematologica

Narni F, Colò A, Venturelli D, Selleri L, Donelli A, Tabilio A, Artusi T, Di Prisco U, Torelli G, Torelli U

Promyelocytic crisis of chronic myeloid leukaemia.

British journal of haematology

Emilia G, Sacchi S, Selleri L, Zucchini P, Artusi T, Torelli U

Molecular study of the Philadelphia translocation in chronic myelogenous leukemia in different stages of disease.

Haematologica

Torelli G, Selleri L, Emilia G, Narni F, Colò A, Zucchini P, Donelli A, Venturelli D, Torelli U

Simultaneously increased expression of the c-myc and mu chain genes in the acute blastic transformation of a chronic lymphocytic leukaemia.

British journal of haematology

Torelli UL, Torelli GM, Emilia G, Selleri L, Venturelli D, Artusi T, Donelli A, Colò A, Fornieri C

Clinical subsets of scleroderma: relevance of fluorescent and precipitating antinuclear antibodies.

Clinical and experimental rheumatology

Cassani F, Tosti A, Bianchi FB, Fusconi M, Selleri L, Baffoni L, Veronesi S, Volta U, Lenzi M, Pisi E

Nuclear protrusions and marker chromosomes in lymphocytes of two patients with cutaneous T-cell lymphoma.

Acta haematologica

Emilia G, Torelli G, Sacchi S, Zucchini P, Selleri L, Temperani P, Torelli U

Growth-dependent expression of human Mr 53,000 tumor antigen messenger RNA in normal and neoplastic cells.

Cancer research

Calabretta B, Kaczmarek L, Selleri L, Torelli G, Ming PM, Ming SC, Mercer WE

Cellular levels of mRNA from c-myc, c-myb and c-fes onc-genes in normal myeloid and erythroid precursors of human bone marrow: an in situ hybridization study.

British journal of haematology

Emilia G, Donelli A, Ferrari S, Torelli U, Selleri L, Zucchini P, Moretti L, Venturelli D, Ceccherelli G, Torelli G

Differential patterns of expression of cell cycle-related genes in blast cells of acute myeloid leukemia.

Leukemia research

Torelli U, Selleri L, Venturelli D, Donelli A, Emilia G, Ceccherelli G, Turchi L, Torelli G

Activation of c-myb expression by phytohemagglutinin stimulation in normal human T lymphocytes.

Molecular and cellular biology

Torelli G, Selleri L, Donelli A, Ferrari S, Emilia G, Venturelli D, Moretti L, Torelli U

Expression of human c-fes onc-gene occurs at detectable levels in myeloid but not in lymphoid cell populations.

British journal of haematology

Ferrari S, Torelli U, Selleri L, Donelli A, Venturelli D, Moretti L, Torelli G

Study of the levels of expression of two oncogenes, c-myc and c-myb, in acute and chronic leukemias of both lymphoid and myeloid lineage.

Leukemia research

Ferrari S, Torelli U, Selleri L, Donelli A, Venturelli D, Narni F, Moretti L, Torelli G

Low-dose intravenous pepsin-treated gammaglobulin for idiopathic thrombocytopenic purpura in adults.

British journal of haematology

Emilia G, Sacchi S, Torelli G, Selleri L, Torelli U