Professor
M_Anatomy
In our lab we study how autophagy and the lysosome regulate the response to cellular stress to promote cancer progression.
Publications
Hypoxia Induces Extensive Protein and Proteolytic Remodeling of the Cell Surface in Pancreatic Adenocarcinoma (PDAC) Cell Lines.
Journal of proteome research
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins.
Science (New York, N.Y.)
Functional screen identifies RBM42 as a mediator of oncogenic mRNA translation specificity.
Nature cell biology
Leucine Aminopeptidase LyLAP enables lysosomal degradation of membrane proteins.
bioRxiv : the preprint server for biology
A multi-subunit autophagic capture complex facilitates degradation of ER stalled MHC-I in pancreatic cancer.
bioRxiv : the preprint server for biology
Functional screen for mediators of onco-mRNA translation specificity.
bioRxiv : the preprint server for biology
Ocular TB in Western Australia.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology.
Nature reviews. Molecular cell biology
Emerging roles of the MiT/TFE factors in cancer.
Trends in cancer
Recent Reports on Bioactive Compounds from Marine Cyanobacteria in Relation to Human Health Applications.
Life (Basel, Switzerland)
Coordinated transcriptional and catabolic programs support iron dependent adaptation to RAS-MAPK pathway inhibition in pancreatic cancer.
Cancer discovery
Electrochemical Capillary Driven Immunoassay for Detection of SARS-CoV-2.
ACS measurement science au
Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1.
Science (New York, N.Y.)
Autophagy in cancer cell remodeling and quality control.
Molecular cell
Cross-tissue and generation predictability of relative Wolbachia densities in the mosquito Aedes aegypti.
Parasites & vectors
Built to last: lysosome remodeling and repair in health and disease.
Trends in cell biology
Challenges and opportunities in 2021.
Nature cancer
Zooming in on the cell biology of disease.
Molecular biology of the cell
Autophagy in major human diseases.
The EMBO journal
Characterization of subclinical ZIKV infection in immune-competent guinea pigs and mice.
The Journal of general virology
Oncogene-regulated release of extracellular vesicles.
Developmental cell
Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth.
Nature cell biology
NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C.
Developmental cell
Dengue virus dominates lipid metabolism modulations in Wolbachia-coinfected Aedes aegypti.
Communications biology
Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancer.
eLife
Host Control of Tumor Feeding: Autophagy Holds the Key.
Cell metabolism
MiT/TFE Family of Transcription Factors, Lysosomes, and Cancer.
Annual review of cancer biology
Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth.
Science (New York, N.Y.)
Rapid and specific detection of Asian- and African-lineage Zika viruses.
Science translational medicine
Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex.
Science (New York, N.Y.)
Vector Competence of American Mosquitoes for Three Strains of Zika Virus.
PLoS neglected tropical diseases
Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance.
Cell metabolism
The Lysosome as a Regulatory Hub.
Annual review of cell and developmental biology
Changes in the Proteome of Langat-Infected Ixodes scapularis ISE6 Cells: Metabolic Pathways Associated with Flavivirus Infection.
PLoS neglected tropical diseases
Pancreatic Cancer Metabolism: Breaking It Down to Build It Back Up.
Cancer discovery
YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression.
Cell reports
Stromal response to Hedgehog signaling restrains pancreatic cancer progression.
Proceedings of the National Academy of Sciences of the United States of America
CDK4/6 and IGF1 receptor inhibitors synergize to suppress the growth of p16INK4A-deficient pancreatic cancers.
Cancer research
On oncogenes and tumor suppressor genes in the mammary gland.
Cold Spring Harbor perspectives in biology
The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics.
The Journal of cell biology
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer research
Internalization, intracellular trafficking, and biodistribution of monoclonal antibody 806: a novel anti-epidermal growth factor receptor antibody.
Neoplasia (New York, N.Y.)
The efficacy of epidermal growth factor receptor-specific antibodies against glioma xenografts is influenced by receptor levels, activation status, and heterodimerization.
Clinical cancer research : an official journal of the American Association for Cancer Research
Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate.
Proceedings of the National Academy of Sciences of the United States of America
Two synaptojanin 1 isoforms are recruited to clathrin-coated pits at different stages.
Proceedings of the National Academy of Sciences of the United States of America
Treatment of human tumor xenografts with monoclonal antibody 806 in combination with a prototypical epidermal growth factor receptor-specific antibody generates enhanced antitumor activity.
Clinical cancer research : an official journal of the American Association for Cancer Research
Antitumor efficacy of cytotoxic drugs and the monoclonal antibody 806 is enhanced by the EGF receptor inhibitor AG1478.
Proceedings of the National Academy of Sciences of the United States of America