Susan Fisher, PhD

PROF-HCOMP
Ob/Gyn, Reproductive Sciences
+1 415 476-5297

Our group works in three areas. In the first, we are studying the mechanisms used by the trophoblast cells of the human placenta to invade the uterus during normal pregnancy. Human fetal development depends on the embryo's ability to rapidly gain access to the maternal circulation. The cytotrophoblasts that form the fetal portion of the human placenta have solved this problem by transiently exhibiting certain invasive, tumor-like properties. Our studies show that, in normal pregnancy, cytotrophoblast invasion, both in vivo and in vitro, is accompanied by a dramatic switch in the cells' expression of matrix-degrading metalloproteinases and adhesion molecules. Function-perturbation experiments suggest that cytotrophoblasts carefully regulate their invasive potential by simultaneously expressing a number of molecules that either promote or inhibit invasion. Additionally, we found that cytotrophoblasts that replace the endothelial lining of uterine blood vessels also have the amazing ability to mimic the adhesion phenotype of vascular cells. This phenomenon is likely to be a critical component of normal placentation. What controls this highly unusual differentiation process? Since cytotrophoblasts target large-bore arterioles for invasion, we reasoned that oxygen tension could play a role. Recently, we showed that oxygen controls whether cells proliferate or exit the cell cycle and differentiate; Eph/ephrin family members, transmembrane ligands and receptors, pattern invasion in terms of arterial bias. Finally, we use information about molecular aspects of cytotrophoblast function in normal pregnancy to search for defects that are associated with pregnancy complications such as preeclampsia (e.g., dangerously high blood pressure). For example, our work shows that this pregnancy complication is characterized by specific aberrations in trophoblast secretion of vasculogenic/angiogenic substances.

In parallel, our lab has begun studying the earliest stages of human development using human embryonic stem cells as a model system. Our work to date has focused on deriving additional lines using feeders formed from human placental cells. We recently made the surprising discovery that the cells exhibit apical-basal type polarization. Currently we are investigating how this highly specialized phenomenon is related to pluripotency. Our recently funded CIRM comprehensive grant is focused on constructing a fate map of the human embryo.

Finally, we are using mass spectrometry-based approaches for proteome analyses. Three projects are under way. The first is compilation of an initial draft of the salivary proteome of healthy individuals as a first step in using this body fluid for diagnosis of common diseases. The second is an analysis of the primary proteome and protein complexes of the soil organism Desulfovibrio vulgaris. The goal of the third and newest project is to formulate novel methods that enable robust mass spectrometry-based platforms for the discovery of biomarkers in body fluid for the early detection of tumors.

Publications: 

Vedolizumab Antagonizes MAdCAM-1-Dependent Human Placental Cytotrophoblast Adhesion and Invasion In Vitro.

Inflammatory bowel diseases

Blaisdell A, Zhou Y, Kattah MG, Fisher SJ, Mahadevan U

Bisphenol A replacement chemicals, BPF and BPS, induce protumorigenic changes in human mammary gland organoid morphology and proteome.

Proceedings of the National Academy of Sciences of the United States of America

Winkler J, Liu P, Phong K, Hinrichs JH, Ataii N, Williams K, Hadler-Olsen E, Samson S, Gartner ZJ, Fisher S, Werb Z

Establishment of fetomaternal tolerance through glycan-mediated B cell suppression.

Nature

Rizzuto G, Brooks JF, Tuomivaara ST, McIntyre TI, Ma S, Rideaux D, Zikherman J, Fisher SJ, Erlebacher A

RNA profiling of laser microdissected human trophoblast subtypes at mid-gestation reveals a role for cannabinoid signaling in invasion.

Development (Cambridge, England)

Gormley M, Oliverio O, Kapidzic M, Ona K, Hall S, Fisher SJ

Global proteomic analyses of human cytotrophoblast differentiation/invasion.

Development (Cambridge, England)

Chen H, Williams KE, Kwan EY, Kapidzic M, Puckett KA, Aburajab RK, Robinson JF, Fisher SJ

The Placenta - Fast, Loose, and in Control.

The New England journal of medicine

Costello JF, Fisher SJ

Organophosphate Flame Retardants, Highly Fluorinated Chemicals, and Biomarkers of Placental Development and Disease during Mid-Gestation.

Toxicological sciences : an official journal of the Society of Toxicology

Varshavsky JR, Robinson JF, Zhou Y, Puckett KA, Kwan E, Buarpung S, Aburajab R, Gaw SL, Sen S, Gao S, Smith SC, Park JS, Zakharevich I, Gerona RR, Fisher SJ, Woodruff TJ

Cytotrophoblast extracellular vesicles enhance decidual cell secretion of immune modulators via TNF-alpha.

Development (Cambridge, England)

Taylor SK, Houshdaran S, Robinson JF, Gormley MJ, Kwan EY, Kapidzic M, Schilling B, Giudice LC, Fisher SJ

Gravidity-dependent associations between interferon response and birth weight in placental malaria.

Malaria journal

Quanquin NM, Barres LG, Aliyari SR, Day NT, Gerami H, Fisher SJ, Kakuru A, Kamya MR, Havlir DV, Feeney M, Dorsey G, Cheng G, Gaw SL

Racial/ethnic and geographic differences in polybrominated diphenyl ether (PBDE) levels across maternal, placental, and fetal tissues during mid-gestation.

Scientific reports

Varshavsky JR, Sen S, Robinson JF, Smith SC, Frankenfield J, Wang Y, Yeh G, Park JS, Fisher SJ, Woodruff TJ

Up-regulated cytotrophoblast DOCK4 contributes to over-invasion in placenta accreta spectrum.

Proceedings of the National Academy of Sciences of the United States of America

McNally L, Zhou Y, Robinson JF, Zhao G, Chen LM, Chen H, Kim MY, Kapidzic M, Gormley M, Hannibal R, Fisher SJ

Association of polybrominated diphenyl ether (PBDE) levels with biomarkers of placental development and disease during mid-gestation.

Environmental health : a global access science source

Varshavsky JR, Robinson JF, Zhou Y, Puckett KA, Kwan E, Buarpung S, Aburajab R, Gaw SL, Sen S, Smith SC, Frankenfield J, Park JS, Fisher SJ, Woodruff TJ

Discordant Zika virus findings in twin pregnancies complicated by antenatal Zika virus exposure: a prospective cohort.

The Journal of infectious diseases

Sobhani NC, Avvad-Portari E, Nascimento ACM, Machado HN, Lobato DSS, Pereira JP, Esquivel MS, Vasconcelos ZC, Zin AA, Tsui I, Adachi K, Brickley EB, Fisher SJ, Nielsen-Saines K, Brasil P, Moreira ME, Gaw SL

Trisomy 21 is Associated with Caspase-2 Upregulation in Cytotrophoblasts at the Maternal-Fetal Interface.

Reproductive sciences (Thousand Oaks, Calif.)

Leon-Martinez D, Robinson JF, Zdravkovic T, Genbacev O, Gormley M, Mcmaster M, Fisher SJ, Bianco K

Reply to GASTRO-D-19-00915.

Gastroenterology

Mahadevan U, Fisher S, Riley L, Chambers C, Jain R, Robinson C

Hormone receptor expression of colorectal cancer diagnosed during the peri-partum period.

Endocrine connections

Silverstein J, Kidder W, Fisher SJ, Hope TA, Maisel S, Ng D, Van Zifle J, Atreya C, Van Loon K

Menstrual cycle-dependent alterations in glycosylation: a roadmap for defining biomarkers of favorable and unfavorable mucus.

Journal of assisted reproduction and genetics

Reynoso-Prieto M, Takeda M, Prakobphol A, Seidman D, Averbach S, Fisher S, Smith-McCune K

Differential Activation of Fetal Hofbauer Cells in Primigravidas Is Associated with Decreased Birth Weight in Symptomatic Placental Malaria.

Malaria research and treatment

Gaw SL, Hromatka BS, Ngeleza S, Buarpung S, Ozarslan N, Tshefu A, Fisher SJ

Genomic Profiling of BDE-47 Effects on Human Placental Cytotrophoblasts.

Toxicological sciences : an official journal of the Society of Toxicology

Robinson JF, Kapidzic M, Hamilton EG, Chen H, Puckett KW, Zhou Y, Ona K, Parry E, Wang Y, Park JS, Costello JF, Fisher SJ

Placental Structure in Preterm Birth Among HIV-Positive Versus HIV-Negative Women in Kenya.

Journal of acquired immune deficiency syndromes (1999)

Obimbo MM, Zhou Y, McMaster MT, Cohen CR, Qureshi Z, Ong'ech J, Ogeng'o JA, Fisher SJ

Large Differences in Small RNA Composition Between Human Biofluids.

Cell reports

Godoy PM, Bhakta NR, Barczak AJ, Cakmak H, Fisher S, MacKenzie TC, Patel T, Price RW, Smith JF, Woodruff PG, Erle DJ

Reply to Liu et al.: Decidualization defect in severe preeclampsia.

Proceedings of the National Academy of Sciences of the United States of America

Garrido-Gomez T, Fisher SJ, Simón C

Altered downstream target gene expression of the placental Vitamin D receptor in human idiopathic fetal growth restriction.

Cell cycle (Georgetown, Tex.)

Nguyen TPH, Yong HEJ, Chollangi T, Brennecke SP, Fisher SJ, Wallace EM, Ebeling PR, Murthi P

Baby's First Organ.

Scientific American

Erlebacher A, Fisher SJ

Defective decidualization during and after severe preeclampsia reveals a possible maternal contribution to the etiology.

Proceedings of the National Academy of Sciences of the United States of America

Garrido-Gomez T, Dominguez F, Quiñonero A, Diaz-Gimeno P, Kapidzic M, Gormley M, Ona K, Padilla-Iserte P, McMaster M, Genbacev O, Perales A, Fisher SJ, Simón C

Reductive dissolution of supergrowth carbon nanotubes for tougher nanocomposites by reactive coagulation spinning.

Nanoscale

Clancy AJ, Anthony DB, Fisher SJ, Leese HS, Roberts CS, Shaffer MSP

Transcriptional Dynamics of Cultured Human Villous Cytotrophoblasts.

Endocrinology

Robinson JF, Kapidzic M, Gormley M, Ona K, Dent T, Seifikar H, Hamilton EG, Fisher SJ

Alterations in the Salivary Proteome and N-Glycome of Sjögren's Syndrome Patients.

Journal of proteome research

Hall SC, Hassis ME, Williams KE, Albertolle ME, Prakobphol A, Dykstra AB, Laurance M, Ona K, Niles RK, Prasad N, Gormley M, Shiboski C, Criswell LA, Witkowska HE, Fisher SJ

Preeclampsia: novel insights from global RNA profiling of trophoblast subpopulations.

American journal of obstetrics and gynecology

Gormley M, Ona K, Kapidzic M, Garrido-Gomez T, Zdravkovic T, Fisher SJ

The human chorion contains definitive hematopoietic stem cells from the fifteenth week of gestation.

Development (Cambridge, England)

Muench MO, Kapidzic M, Gormley M, Gutierrez AG, Ponder KL, Fomin ME, Beyer AI, Stolp H, Qi Z, Fisher SJ, Bárcena A

Severe pre-eclampsia is associated with alterations in cytotrophoblasts of the smooth chorion.

Development (Cambridge, England)

Garrido-Gomez T, Ona K, Kapidzic M, Gormley M, Simón C, Genbacev O, Fisher SJ

The Macronuclear Genome of Stentor coeruleus Reveals Tiny Introns in a Giant Cell.

Current biology : CB

Slabodnick MM, Ruby JG, Reiff SB, Swart EC, Gosai S, Prabakaran S, Witkowska E, Larue GE, Fisher S, Freeman RM, Gunawardena J, Chu W, Stover NA, Gregory BD, Nowacki M, Derisi J, Roy SW, Marshall WF, Sood P

Placental transcriptomes in the common aneuploidies reveal critical regions on the trisomic chromosomes and genome-wide effects.

Prenatal diagnosis

Bianco K, Gormley M, Farrell J, Zhou Y, Oliverio O, Tilden H, McMaster M, Fisher SJ

Stromal Cell-Derived Factor 2: A Novel Protein that Interferes in Endoplasmic Reticulum Stress Pathway in Human Placental Cells.

Biology of reproduction

Lorenzon-Ojea AR, Guzzo CR, Kapidzic M, Fisher SJ, Bevilacqua E

Integrin a4-positive human trophoblast progenitors: functional characterization and transcriptional regulation.

Human reproduction (Oxford, England)

Genbacev O, Larocque N, Ona K, Prakobphol A, Garrido-Gomez T, Kapidzic M, Bárcena A, Gormley M, Fisher SJ

Novel aspects of sialoglycan recognition by the Siglec-like domains of streptococcal SRR glycoproteins.

Glycobiology

Bensing BA, Khedri Z, Deng L, Yu H, Prakobphol A, Fisher SJ, Chen X, Iverson TM, Varki A, Sullam PM

Preeclampsia and Inflammatory Preterm Labor Alter the Human Placental Hematopoietic Niche.

Reproductive sciences (Thousand Oaks, Calif.)

Ponder KL, Bárcena A, Bos FL, Gormley M, Zhou Y, Ona K, Kapidzic M, Zovein AC, Fisher SJ

Quantitative proteomic analyses of mammary organoids reveals distinct signatures after exposure to environmental chemicals.

Proceedings of the National Academy of Sciences of the United States of America

Williams KE, Lemieux GA, Hassis ME, Olshen AB, Fisher SJ, Werb Z

Bacterial Interactomes: Interacting Protein Partners Share Similar Function and Are Validated in Independent Assays More Frequently Than Previously Reported.

Molecular & cellular proteomics : MCP

Shatsky M, Allen S, Gold BL, Liu NL, Juba TR, Reveco SA, Elias DA, Prathapam R, He J, Yang W, Szakal ED, Liu H, Singer ME, Geller JT, Lam BR, Saini A, Trotter VV, Hall SC, Fisher SJ, Brenner SE, Chhabra SR, Hazen TC, Wall JD, Witkowska HE, Biggin MD, Chandonia JM, Butland G

A genomics-based framework for identifying biomarkers of human neurodevelopmental toxicity.

Reproductive toxicology (Elmsford, N.Y.)

Robinson JF, Gormley MJ, Fisher SJ

Mass spectrometry-based analyses showing the effects of secretor and blood group status on salivary N-glycosylation.

Clinical proteomics

Albertolle ME, Hassis ME, Ng CJ, Cuison S, Williams K, Prakobphol A, Dykstra AB, Hall SC, Niles RK, Ewa Witkowska H, Fisher SJ

Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification.

Development (Cambridge, England)

Zdravkovic T, Nazor KL, Larocque N, Gormley M, Donne M, Hunkapillar N, Giritharan G, Bernstein HS, Wei G, Hebrok M, Zeng X, Genbacev O, Mattis A, McMaster MT, Krtolica A, Valbuena D, Simón C, Laurent LC, Loring JF, Fisher SJ

Placenta: the forgotten organ.

Annual review of cell and developmental biology

Maltepe E, Fisher SJ

Why is placentation abnormal in preeclampsia?

American journal of obstetrics and gynecology

Fisher SJ

Human Stem Cells from Single Blastomeres Reveal Pathways of Embryonic or Trophoblast Fate Specification (in Press)

Development

Zdravkovic T, Nazor KL, Larocque N, Gormley M, Donne M, Hunkapiller N, Gnanaratnam G, Bernstein HS, Wei G, Hebrok M, Zeng X, Genbacev O, Mattis A, McMaster MT, Krtolica A, Valbuena D, Simón C, Laurent LC, Loring JF, and Fisher SJ.

Evaluating the effects of preanalytical variables on the stability of the human plasma proteome.

Analytical biochemistry

Hassis ME, Niles RK, Braten MN, Albertolle ME, Ewa Witkowska H, Hubel CA, Fisher SJ, Williams KE

Integrative analysis of 111 reference human epigenomes.

Nature

Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon G, Sandstrom RS, Eaton ML, Wu YC, Pfenning AR, Wang X, Claussnitzer M, Liu Y, Coarfa C, Harris RA, Shoresh N, Epstein CB, Gjoneska E, Leung D, Xie W, Hawkins RD, Lister R, Hong C, Gascard P, Mungall AJ, Moore R, Chuah E, Tam A, Canfield TK, Hansen RS, Kaul R, Sabo PJ, Bansal MS, Carles A, Dixon JR, Farh KH, Feizi S, Karlic R, Kim AR, Kulkarni A, Li D, Lowdon R, Elliott G, Mercer TR, Neph SJ, Onuchic V, Polak P, Rajagopal N, Ray P, Sallari RC, Siebenthall KT, Sinnott-Armstrong NA, Stevens M, Thurman RE, Wu J, Zhang B, Zhou X, Beaudet AE, Boyer LA, De Jager PL, Farnham PJ, Fisher SJ, Haussler D, Jones SJ, Li W, Marra MA, McManus MT, Sunyaev S, Thomson JA, Tlsty TD, Tsai LH, Wang W, Waterland RA, Zhang MQ, Chadwick LH, Bernstein BE, Costello JF, Ecker JR, Hirst M, Meissner A, Milosavljevic A, Ren B, Stamatoyannopoulos JA, Wang T, Kellis M

Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma.

Molecular & cellular proteomics : MCP

Abbatiello SE, Schilling B, Mani DR, Zimmerman LJ, Hall SC, MacLean B, Albertolle M, Allen S, Burgess M, Cusack MP, Gosh M, Hedrick V, Held JM, Inerowicz HD, Jackson A, Keshishian H, Kinsinger CR, Lyssand J, Makowski L, Mesri M, Rodriguez H, Rudnick P, Sadowski P, Sedransk N, Shaddox K, Skates SJ, Kuhn E, Smith D, Whiteaker JR, Whitwell C, Zhang S, Borchers CH, Fisher SJ, Gibson BW, Liebler DC, MacCoss MJ, Neubert TA, Paulovich AG, Regnier FE, Tempst P, Carr SA

Roadmay Epigenomics Consortium: Integrative Analysis of 111 Reference Human Epigenomes

Nature

Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon G, Sandstrom RS, Eaton ML, Wu YC, Pfenning AR, Wang X, Claussnitzer M, Liu Y, Coarfa C, Harris RA, Shoresh N, Epstein CB, Gjoneska E, Leung D, Xie W, Hawkins RD, Lister R, Hong C, Gascard P, Mungall AJ, Moore R, Chuah E, Tam A, Canfield TK, Hansen RS, Kaul R, Sabo PJ, Bansal MS, Carles A, Dixon JR, Farh KH, Feizi S, Karlic R, Kim AR, Kulkarni A, Li D, Lowdon R, Elliott G, Mercer TR, Neph SJ, Onuchic V, Polak P, Rajagopal N, Ray P, Sallari RC, Siebenthall KT, Sinnott-Armstrong NA, Stevens M, Thurman RE, Wu J, Zhang B, Zhou X, Beaudet AE, Boyer LA, De Jager PL, Farnham PJ, Fisher SJ, Haussler D, Jones SJ, Li W, Marra MA, McManus MT, Sunyaev S, Thomson JA, Tlsty TD, Tsai LH, Wang W, Waterland RA, Zhang MQ, Chadwick LH, Bernstein BE, Costello JF, Ecker JR, Hirst M, Meissner A, Milosavljevic A, Ren B, Stamatoyannopoulos JA, Wang T, Kellis M.

Perdeuteration: improved visualization of solvent structure in neutron macromolecular crystallography.

Acta crystallographica. Section D, Biological crystallography

Fisher SJ, Blakeley MP, Howard EI, Petit-Haertlein I, Haertlein M, Mitschler A, Cousido-Siah A, Salvay AG, Popov A, Muller-Dieckmann C, Petrova T, Podjarny A

Urine, peritoneal fluid and omental fat proteomes of reproductive age women: Endometriosis-related changes and associations with endocrine disrupting chemicals.

Journal of proteomics

Williams KE, Miroshnychenko O, Johansen EB, Niles RK, Sundaram R, Kannan K, Albertolle M, Zhou Y, Prasad N, Drake PM, Giudice LC, Hall SC, Witkowska HE, Buck Louis GM, Fisher SJ

Rbpj links uterine transformation and embryo orientation.

Cell research

Robinson JF, Fisher SJ

Preterm labor: one syndrome, many causes.

Science (New York, N.Y.)

Romero R, Dey SK, Fisher SJ

Stromal cell derived factor-2 (Sdf2): a novel protein expressed in mouse.

The international journal of biochemistry & cell biology

Lorenzon-Ojea AR, Caldeira W, Ribeiro AF, Fisher SJ, Guzzo CR, Bevilacqua E

Phosphoprotein secretome of tumor cells as a source of candidates for breast cancer biomarkers in plasma.

Molecular & cellular proteomics : MCP

Zawadzka AM, Schilling B, Cusack MP, Sahu AK, Drake P, Fisher SJ, Benz CC, Gibson BW

Reversal of gene dysregulation in cultured cytotrophoblasts reveals possible causes of preeclampsia.

The Journal of clinical investigation

Zhou Y, Gormley MJ, Hunkapiller NM, Kapidzic M, Stolyarov Y, Feng V, Nishida M, Drake PM, Bianco K, Wang F, McMaster MT, Fisher SJ

Maternal decidual macrophages inhibit NK cell killing of invasive cytotrophoblasts during human pregnancy.

Biology of reproduction

Co EC, Gormley M, Kapidzic M, Rosen DB, Scott MA, Stolp HA, McMaster M, Lanier LL, Bárcena A, Fisher SJ

Protein composition of bronchoalveolar lavage fluid and airway surface liquid from newborn pigs.

American journal of physiology. Lung cellular and molecular physiology

Bartlett JA, Albertolle ME, Wohlford-Lenane C, Pezzulo AA, Zabner J, Niles RK, Fisher SJ, McCray PB, Williams KE

Design, implementation and multisite evaluation of a system suitability protocol for the quantitative assessment of instrument performance in liquid chromatography-multiple reaction monitoring-MS (LC-MRM-MS).

Molecular & cellular proteomics : MCP

Abbatiello SE, Mani DR, Schilling B, Maclean B, Zimmerman LJ, Feng X, Cusack MP, Sedransk N, Hall SC, Addona T, Allen S, Dodder NG, Ghosh M, Held JM, Hedrick V, Inerowicz HD, Jackson A, Keshishian H, Kim JW, Lyssand JS, Riley CP, Rudnick P, Sadowski P, Shaddox K, Smith D, Tomazela D, Wahlander A, Waldemarson S, Whitwell CA, You J, Zhang S, Kinsinger CR, Mesri M, Rodriguez H, Borchers CH, Buck C, Fisher SJ, Gibson BW, Liebler D, Maccoss M, Neubert TA, Paulovich A, Regnier F, Skates SJ, Tempst P, Wang M, Carr SA

Retrospective. Robert G. Edwards (1925-2013).

Science (New York, N.Y.)

Fisher SJ, Giudice LC

Human trophoblast progenitors: where do they reside?

Seminars in reproductive medicine

Genbacev O, Lamb JD, Prakobphol A, Donne M, McMaster MT, Fisher SJ

Elucidation of N-glycosites within human plasma glycoproteins for cancer biomarker discovery.

Methods in molecular biology (Clifton, N.J.)

Drake P, Schilling B, Gibson B, Fisher S

Polysialic acid enhances the migration and invasion of human cytotrophoblasts.

Glycobiology

Hromatka BS, Drake PM, Kapidzic M, Stolp H, Goldfien GA, Shih IeM, Fisher SJ

High-throughput isolation and characterization of untagged membrane protein complexes: outer membrane complexes of Desulfovibrio vulgaris.

Journal of proteome research

Walian PJ, Allen S, Shatsky M, Zeng L, Szakal ED, Liu H, Hall SC, Fisher SJ, Lam BR, Singer ME, Geller JT, Brenner SE, Chandonia JM, Hazen TC, Witkowska HE, Biggin MD, Jap BK

Lectin chromatography/mass spectrometry discovery workflow identifies putative biomarkers of aggressive breast cancers.

Journal of proteome research

Drake PM, Schilling B, Niles RK, Prakobphol A, Li B, Jung K, Cho W, Braten M, Inerowicz HD, Williams K, Albertolle M, Held JM, Iacovides D, Sorensen DJ, Griffith OL, Johansen E, Zawadzka AM, Cusack MP, Allen S, Gormley M, Hall SC, Witkowska HE, Gray JW, Regnier F, Gibson BW, Fisher SJ

Breaking the bottleneck in the protein biomarker pipeline.

Clinical chemistry

Witkowska HE, Hall SC, Fisher SJ

SGK1: a fine balancing act for human pregnancy.

Nature medicine

Fisher SJ, Giudice LC

Human placenta and chorion: potential additional sources of hematopoietic stem cells for transplantation.

Transfusion

Bárcena A, Muench MO, Kapidzic M, Gormley M, Goldfien GA, Fisher SJ

Establishment of human trophoblast progenitor cell lines from the chorion.

Stem cells (Dayton, Ohio)

Genbacev O, Donne M, Kapidzic M, Gormley M, Lamb J, Gilmore J, Larocque N, Goldfien G, Zdravkovic T, McMaster MT, Fisher SJ

Automated iterative MS/MS acquisition: a tool for improving efficiency of protein identification using a LC-MALDI MS workflow.

Analytical chemistry

Liu H, Yang L, Khainovski N, Dong M, Hall SC, Fisher SJ, Biggin MD, Jin J, Witkowska HE

A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia.

Development (Cambridge, England)

Hunkapiller NM, Gasperowicz M, Kapidzic M, Plaks V, Maltepe E, Kitajewski J, Cross JC, Fisher SJ

Pre-eclampsia is associated with elevated CXCL12 levels in placental syncytiotrophoblasts and maternal blood.

European journal of obstetrics, gynecology, and reproductive biology

Schanz A, Winn VD, Fisher SJ, Blumenstein M, Heiss C, Hess AP, Kruessel JS, Mcmaster M, North RA

GROa regulates human embryonic stem cell self-renewal or adoption of a neuronal fate.

Differentiation; research in biological diversity

Krtolica A, Larocque N, Genbacev O, Ilic D, Coppe JP, Patil CK, Zdravkovic T, McMaster M, Campisi J, Fisher SJ

Transcriptomic signature of trophoblast differentiation in a human embryonic stem cell model.

Biology of reproduction

Marchand M, Horcajadas JA, Esteban FJ, McElroy SL, Fisher SJ, Giudice LC

The Impact of Preeclampsia on Gene Expression at the Maternal-Fetal Interface.

Pregnancy hypertension

Winn VD, Gormley M, Fisher SJ

Trophoblast stem cells.

Biology of reproduction

Roberts RM, Fisher SJ

A lectin affinity workflow targeting glycosite-specific, cancer-related carbohydrate structures in trypsin-digested human plasma.

Analytical biochemistry

Drake PM, Schilling B, Niles RK, Braten M, Johansen E, Liu H, Lerch M, Sorensen DJ, Li B, Allen S, Hall SC, Witkowska HE, Regnier FE, Gibson BW, Fisher SJ

The placenta: transcriptional, epigenetic, and physiological integration during development.

The Journal of clinical investigation

Maltepe E, Bakardjiev AI, Fisher SJ

Research ethics. NIH guidelines for stem cell research and gamete donors.

Science (New York, N.Y.)

Lo B, Parham L, Cedars M, Fisher S, Gates E, Giudice L, Halme DG, Hershon W, Kriegstein A, Rao R, Roberts C, Wagner R

Repeatability and reproducibility in proteomic identifications by liquid chromatography-tandem mass spectrometry.

Journal of proteome research

Tabb DL, Vega-Montoto L, Rudnick PA, Variyath AM, Ham AJ, Bunk DM, Kilpatrick LE, Billheimer DD, Blackman RK, Cardasis HL, Carr SA, Clauser KR, Jaffe JD, Kowalski KA, Neubert TA, Regnier FE, Schilling B, Tegeler TJ, Wang M, Wang P, Whiteaker JR, Zimmerman LJ, Fisher SJ, Gibson BW, Kinsinger CR, Mesri M, Rodriguez H, Stein SE, Tempst P, Paulovich AG, Liebler DC, Spiegelman C

Cloning mice and men: prohibiting the use of iPS cells for human reproductive cloning.

Cell stem cell

Lo B, Parham L, Alvarez-Buylla A, Cedars M, Conklin B, Fisher S, Gates E, Giudice L, Halme DG, Hershon W, Kriegstein A, Kwok PY, Wagner R

Analytical validation of protein-based multiplex assays: a workshop report by the NCI-FDA interagency oncology task force on molecular diagnostics.

Clinical chemistry

Rodriguez H, Tezak Z, Mesri M, Carr SA, Liebler DC, Fisher SJ, Tempst P, Hiltke T, Kessler LG, Kinsinger CR, Philip R, Ransohoff DF, Skates SJ, Regnier FE, Anderson NL, Mansfield E

Protein-based multiplex assays: mock presubmissions to the US Food and Drug Administration.

Clinical chemistry

Regnier FE, Skates SJ, Mesri M, Rodriguez H, Tezak Z, Kondratovich MV, Alterman MA, Levin JD, Roscoe D, Reilly E, Callaghan J, Kelm K, Brown D, Philip R, Carr SA, Liebler DC, Fisher SJ, Tempst P, Hiltke T, Kessler LG, Kinsinger CR, Ransohoff DF, Mansfield E, Anderson NL

Sweetening the pot: adding glycosylation to the biomarker discovery equation.

Clinical chemistry

Drake PM, Cho W, Li B, Prakobphol A, Johansen E, Anderson NL, Regnier FE, Gibson BW, Fisher SJ

Derivation of human embryonic stem cell lines from biopsied blastomeres on human feeders with minimal exposure to xenomaterials.

Stem cells and development

Ilic D, Giritharan G, Zdravkovic T, Caceres E, Genbacev O, Fisher SJ, Krtolica A

Interlaboratory study characterizing a yeast performance standard for benchmarking LC-MS platform performance.

Molecular & cellular proteomics : MCP

Paulovich AG, Billheimer D, Ham AJ, Vega-Montoto L, Rudnick PA, Tabb DL, Wang P, Blackman RK, Bunk DM, Cardasis HL, Clauser KR, Kinsinger CR, Schilling B, Tegeler TJ, Variyath AM, Wang M, Whiteaker JR, Zimmerman LJ, Fenyo D, Carr SA, Fisher SJ, Gibson BW, Mesri M, Neubert TA, Regnier FE, Rodriguez H, Spiegelman C, Stein SE, Tempst P, Liebler DC

Performance metrics for liquid chromatography-tandem mass spectrometry systems in proteomics analyses.

Molecular & cellular proteomics : MCP

Rudnick PA, Clauser KR, Kilpatrick LE, Tchekhovskoi DV, Neta P, Blonder N, Billheimer DD, Blackman RK, Bunk DM, Cardasis HL, Ham AJ, Jaffe JD, Kinsinger CR, Mesri M, Neubert TA, Schilling B, Tabb DL, Tegeler TJ, Vega-Montoto L, Variyath AM, Wang M, Wang P, Whiteaker JR, Zimmerman LJ, Carr SA, Fisher SJ, Gibson BW, Paulovich AG, Regnier FE, Rodriguez H, Spiegelman C, Tempst P, Liebler DC, Stein SE

A lectin HPLC method to enrich selectively-glycosylated peptides from complex biological samples.

Journal of visualized experiments : JoVE

Johansen E, Schilling B, Lerch M, Niles RK, Liu H, Li B, Allen S, Hall SC, Witkowska HE, Regnier FE, Gibson BW, Fisher SJ, Drake PM

mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells.

Proceedings of the National Academy of Sciences of the United States of America

Zhou J, Su P, Wang L, Chen J, Zimmermann M, Genbacev O, Afonja O, Horne MC, Tanaka T, Duan E, Fisher SJ, Liao J, Chen J, Wang F

Acid-catalyzed oxygen-18 labeling of peptides.

Analytical chemistry

Niles R, Witkowska HE, Allen S, Hall SC, Fisher SJ, Hardt M

A new role for the human placenta as a hematopoietic site throughout gestation.

Reproductive sciences (Thousand Oaks, Calif.)

Bárcena A, Muench MO, Kapidzic M, Fisher SJ

The human placenta is a hematopoietic organ during the embryonic and fetal periods of development.

Developmental biology

Bárcena A, Kapidzic M, Muench MO, Gormley M, Scott MA, Weier JF, Ferlatte C, Fisher SJ

Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2.

Endocrinology

Winn VD, Gormley M, Paquet AC, Kjaer-Sorensen K, Kramer A, Rumer KK, Haimov-Kochman R, Yeh RF, Overgaard MT, Varki A, Oxvig C, Fisher SJ

Human embryonic stem cells as a model system for studying the effects of smoke exposure on the embryo.

Reproductive toxicology (Elmsford, N.Y.)

Zdravkovic T, Genbacev O, LaRocque N, McMaster M, Fisher S

The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions.

Journal of proteome research

Denny P, Hagen FK, Hardt M, Liao L, Yan W, Arellanno M, Bassilian S, Bedi GS, Boontheung P, Cociorva D, Delahunty CM, Denny T, Dunsmore J, Faull KF, Gilligan J, Gonzalez-Begne M, Halgand F, Hall SC, Han X, Henson B, Hewel J, Hu S, Jeffrey S, Jiang J, Loo JA, Ogorzalek Loo RR, Malamud D, Melvin JE, Miroshnychenko O, Navazesh M, Niles R, Park SK, Prakobphol A, Ramachandran P, Richert M, Robinson S, Sondej M, Souda P, Sullivan MA, Takashima J, Than S, Wang J, Whitelegge JP, Witkowska HE, Wolinsky L, Xie Y, Xu T, Yu W, Ytterberg J, Wong DT, Yates JR, Fisher SJ

A "tagless" strategy for identification of stable protein complexes genome-wide by multidimensional orthogonal chromatographic separation and iTRAQ reagent tracking.

Journal of proteome research

Dong M, Yang LL, Williams K, Fisher SJ, Hall SC, Biggin MD, Jin J, Witkowska HE

A mass spectrometry-based strategy for detecting and characterizing endogenous proteinase activities in complex biological samples.

Proteomics

Robinson S, Niles RK, Witkowska HE, Rittenbach KJ, Nichols RJ, Sargent JA, Dixon SE, Prakobphol A, Hall SC, Fisher SJ, Hardt M

Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation.

Molecular cell

Lim ST, Chen XL, Lim Y, Hanson DA, Vo TT, Howerton K, Larocque N, Fisher SJ, Schlaepfer DD, Ilic D

Human embryonic stem cell lines generated without embryo destruction.

Cell stem cell

Chung Y, Klimanskaya I, Becker S, Li T, Maserati M, Lu SJ, Zdravkovic T, Ilic D, Genbacev O, Fisher S, Krtolica A, Lanza R

Chapter 12. Placental remodeling of the uterine vasculature.

Methods in enzymology

Hunkapiller NM, Fisher SJ

Disruption of apical-basal polarity of human embryonic stem cells enhances hematoendothelial differentiation.

Stem cells (Dayton, Ohio)

Krtolica A, Genbacev O, Escobedo C, Zdravkovic T, Nordstrom A, Vabuena D, Nath A, Simon C, Mostov K, Fisher SJ

Comparative analysis of maternal-fetal interface in preeclampsia and preterm labor.

Cell and tissue research

Zhou Y, Bianco K, Huang L, Nien JK, McMaster M, Romero R, Fisher SJ

Focal adhesion kinase controls pH-dependent epidermal barrier homeostasis by regulating actin-directed Na+/H+ exchanger 1 plasma membrane localization.

The American journal of pathology

Ilic D, Mao-Qiang M, Crumrine D, Dolganov G, Larocque N, Xu P, Demerjian M, Brown BE, Lim ST, Ossovskaya V, Schlaepfer DD, Fisher SJ, Feingold KR, Elias PM, Mauro TM

Gene expression profiling of the human maternal-fetal interface reveals dramatic changes between midgestation and term.

Endocrinology

Winn VD, Haimov-Kochman R, Paquet AC, Yang YJ, Madhusudhan MS, Gormley M, Feng KT, Bernlohr DA, McDonagh S, Pereira L, Sali A, Fisher SJ

Decidual stromal cell response to paracrine signals from the trophoblast: amplification of immune and angiogenic modulators.

Biology of reproduction

Hess AP, Hamilton AE, Talbi S, Dosiou C, Nyegaard M, Nayak N, Genbecev-Krtolica O, Mavrogianis P, Ferrer K, Kruessel J, Fazleabas AT, Fisher SJ, Giudice LC

Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.

The Journal of clinical investigation

Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ

MUC1 is a scaffold for selectin ligands in the human uterus.

Frontiers in bioscience : a journal and virtual library

Carson DD, Julian J, Lessey BA, Prakobphol A, Fisher SJ

Nicotine downregulates the l-selectin system that mediates cytotrophoblast emigration from cell columns and attachment to the uterine wall.

Reproductive toxicology (Elmsford, N.Y.)

Zdravkovic T, Genbacev O, Prakobphol A, Cvetkovic M, Schanz A, McMaster M, Fisher SJ

A role for the L-selectin adhesion system in mediating cytotrophoblast emigration from the placenta.

Developmental biology

Prakobphol A, Genbacev O, Gormley M, Kapidzic M, Fisher SJ

Binding of the streptococcal surface glycoproteins GspB and Hsa to human salivary proteins.

Infection and immunity

Takamatsu D, Bensing BA, Prakobphol A, Fisher SJ, Sullam PM

Hair cycle and wound healing in mice with a keratinocyte-restricted deletion of FAK.

Oncogene

Essayem S, Kovacic-Milivojevic B, Baumbusch C, McDonagh S, Dolganov G, Howerton K, Larocque N, Mauro T, Ramirez A, Ramos DM, Fisher SJ, Jorcano JL, Beggs HE, Reichardt LF, Ilic D

Literature watch. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.

Lymphatic research and biology

Red-Horse K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E, Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ

Molecular cytogenetic studies towards the full karyotype analysis of human blastocysts and cytotrophoblasts.

Cytogenetic and genome research

Weier JF, Ferlatte C, Baumgartner A, Jung CJ, Nguyen HN, Chu LW, Pedersen RA, Fisher SJ, Weier HU

EPHB4 regulates chemokine-evoked trophoblast responses: a mechanism for incorporating the human placenta into the maternal circulation.

Development (Cambridge, England)

Red-Horse K, Kapidzic M, Zhou Y, Feng KT, Singh H, Fisher SJ

Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta.

Development (Cambridge, England)

Maltepe E, Krampitz GW, Okazaki KM, Red-Horse K, Mak W, Simon MC, Fisher SJ

Serum-free derivation of human embryonic stem cell lines on human placental fibroblast feeders.

Fertility and sterility

Genbacev O, Krtolica A, Zdravkovic T, Brunette E, Powell S, Nath A, Caceres E, McMaster M, McDonagh S, Li Y, Mandalam R, Lebkowski J, Fisher SJ

The adverse effects of maternal smoking on the human placenta: a review.

Placenta

Zdravkovic T, Genbacev O, McMaster MT, Fisher SJ

Human cytotrophoblasts acquire aneuploidies as they differentiate to an invasive phenotype.

Developmental biology

Weier JF, Weier HU, Jung CJ, Gormley M, Zhou Y, Chu LW, Genbacev O, Wright AA, Fisher SJ

First derivation in Spain of human embryonic stem cell lines: use of long-term cryopreserved embryos and animal-free conditions.

Fertility and sterility

Simón C, Escobedo C, Valbuena D, Genbacev O, Galan A, Krtolica A, Asensi A, Sánchez E, Esplugues J, Fisher S, Pellicer A

Abnormal placentation and the syndrome of preeclampsia.

Seminars in nephrology

McMaster MT, Zhou Y, Fisher SJ

Trisomy 21 is associated with variable defects in cytotrophoblast differentiation along the invasive pathway.

American journal of medical genetics. Part A

Wright A, Zhou Y, Weier JF, Caceres E, Kapidzic M, Tabata T, Kahn M, Nash C, Fisher SJ

Functional and placental expression analysis of the human NRF3 transcription factor.

Molecular endocrinology (Baltimore, Md.)

Chénais B, Derjuga A, Massrieh W, Red-Horse K, Bellingard V, Fisher SJ, Blank V

Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface.

The Journal of clinical investigation

Red-Horse K, Zhou Y, Genbacev O, Prakobphol A, Foulk R, McMaster M, Fisher SJ

Viral and bacterial pathogens at the maternal-fetal interface.

The Journal of infectious diseases

McDonagh S, Maidji E, Ma W, Chang HT, Fisher S, Pereira L

Human pregnancy: the role of chemokine networks at the fetal-maternal interface.

Expert reviews in molecular medicine

Red-Horse K, Drake PM, Fisher SJ

Reciprocal chemokine receptor and ligand expression in the human placenta: implications for cytotrophoblast differentiation.

Developmental dynamics : an official publication of the American Association of Anatomists

Drake PM, Red-Horse K, Fisher SJ

Listeriosis in the pregnant guinea pig: a model of vertical transmission.

Infection and immunity

Bakardjiev AI, Stacy BA, Fisher SJ, Portnoy DA

Trophoblast L-selectin-mediated adhesion at the maternal-fetal interface.

Science (New York, N.Y.)

Genbacev OD, Prakobphol A, Foulk RA, Krtolica AR, Ilic D, Singer MS, Yang ZQ, Kiessling LL, Rosen SD, Fisher SJ

Longitudinal serum concentrations of placental growth factor: evidence for abnormal placental angiogenesis in pathologic pregnancies.

American journal of obstetrics and gynecology

Taylor RN, Grimwood J, Taylor RS, McMaster MT, Fisher SJ, North RA

Trophoblast origin of hCG isoforms: cytotrophoblasts are the primary source of choriocarcinoma-like hCG.

Molecular and cellular endocrinology

Kovalevskaya G, Genbacev O, Fisher SJ, Caceres E, O'Connor JF

When is seeing believing? The use of color Doppler ultrasound to diagnose placenta accreta in the first trimester of pregnancy.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

Fisher SJ, Zhou Y, Huang L, Winn VD

Chemokine expression and function at the human maternal-fetal interface.

Reviews in endocrine & metabolic disorders

Drake PM, Red-Horse K, Fisher SJ

The salivary mucin MG1 (MUC5B) carries a repertoire of unique oligosaccharides that is large and diverse.

Glycobiology

Thomsson KA, Prakobphol A, Leffler H, Reddy MS, Levine MJ, Fisher SJ, Hansson GC

Implantation and the survival of early pregnancy.

The New England journal of medicine

Norwitz ER, Schust DJ, Fisher SJ

Plasma membrane-associated pY397FAK is a marker of cytotrophoblast invasion in vivo and in vitro.

The American journal of pathology

Ilic D, Genbacev O, Jin F, Caceres E, Almeida EA, Bellingard-Dubouchaud V, Schaefer EM, Damsky CH, Fisher SJ

Human placental cytotrophoblasts attract monocytes and CD56(bright) natural killer cells via the actions of monocyte inflammatory protein 1alpha.

The Journal of experimental medicine

Drake PM, Gunn MD, Charo IF, Tsou CL, Zhou Y, Huang L, Fisher SJ

Functional proteomics: examining the effects of hypoxia on the cytotrophoblast protein repertoire.

Biochemistry

Hoang VM, Foulk R, Clauser K, Burlingame A, Gibson BW, Fisher SJ

Conditioned medium from hypoxic cytotrophoblasts alters arterial function.

American journal of obstetrics and gynecology

Gratton RJ, Gandley RE, Genbacev O, McCarthy JF, Fisher SJ, McLaughlin MK

Salivary agglutinin, which binds Streptococcus mutans and Helicobacter pylori, is the lung scavenger receptor cysteine-rich protein gp-340.

The Journal of biological chemistry

Prakobphol A, Xu F, Hoang VM, Larsson T, Bergstrom J, Johansson I, Frängsmyr L, Holmskov U, Leffler H, Nilsson C, Borén T, Wright JR, Strömberg N, Fisher SJ

Concordant in situ and in vitro data show that maternal cigarette smoking negatively regulates placental cytotrophoblast passage through the cell cycle.

Reproductive toxicology (Elmsford, N.Y.)

Genbacev O, McMaster MT, Lazic J, Nedeljkovic S, Cvetkovic M, Joslin R, Fisher SJ

HLA-G, -E, -F preworkshop: tools and protocols for analysis of non-classical class I genes transcription and protein expression.

Human immunology

Paul P, Rouas-Freiss N, Moreau P, Cabestre FA, Menier C, Khalil-Daher I, Pangault C, Onno M, Fauchet R, Martinez-Laso J, Morales P, Villena AA, Giacomini P, Natali PG, Frumento G, Ferrara GB, McMaster M, Fisher S, Schust D, Ferrone S, Dausset J, Geraghty D, Carosella ED

The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta.

Nature genetics

Anson-Cartwright L, Dawson K, Holmyard D, Fisher SJ, Lazzarini RA, Cross JC

Posttranscriptional regulation of human leukocyte antigen G during human extravillous cytotrophoblast differentiation.

Biology of reproduction

Copeman J, Han RN, Caniggia I, McMaster M, Fisher SJ, Cross JC

Id-2 regulates critical aspects of human cytotrophoblast differentiation, invasion and migration.

Development (Cambridge, England)

Janatpour MJ, McMaster MT, Genbacev O, Zhou Y, Dong J, Cross JC, Israel MA, Fisher SJ

Invasive cytotrophoblasts manifest evidence of oxidative stress in preeclampsia.

The American journal of pathology

Many A, Hubel CA, Fisher SJ, Roberts JM, Zhou Y

Lack of human leukocyte antigen-G expression in extravillous trophoblasts is associated with pre-eclampsia.

Molecular human reproduction

Goldman-Wohl DS, Ariel I, Greenfield C, Hochner-Celnikier D, Cross J, Fisher S, Yagel S

The placenta dilemma.

Seminars in reproductive medicine

Fisher SJ

Upregulation of human cytotrophoblast invasion by hepatocyte growth factor.

Journal of reproduction and fertility. Supplement

Nasu K, Zhou Y, McMaster MT, Fisher SJ

Invasive cytotrophoblast apoptosis in pre-eclampsia.

Human reproduction (Oxford, England)

Genbacev O, DiFederico E, McMaster M, Fisher SJ

The placenta and the prolactin family of hormones: regulation of the physiology of pregnancy.

Molecular endocrinology (Baltimore, Md.)

Linzer DI, Fisher SJ

A repertoire of differentially expressed transcription factors that offers insight into mechanisms of human cytotrophoblast differentiation.

Developmental genetics

Janatpour MJ, Utset MF, Cross JC, Rossant J, Dong J, Israel MA, Fisher SJ

Cloning and regulated expression of the Candida albicans phospholipase B (PLB1) gene.

FEMS microbiology letters

Hoover CI, Jantapour MJ, Newport G, Agabian N, Fisher SJ

Trophoblast pseudo-vasculogenesis: faking it with endothelial adhesion receptors.

Current opinion in cell biology

Damsky CH, Fisher SJ

Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity.

Biochemistry

Prakobphol A, Thomsson KA, Hansson GC, Rosen SD, Singer MS, Phillips NJ, Medzihradszky KF, Burlingame AL, Leffler H, Fisher SJ

Complementary expression of HIP, a cell-surface heparan sulfate binding protein, and perlecan at the human fetal-maternal interface.

Biology of reproduction

Rohde LH, Janatpore MJ, McMaster MT, Fisher S, Zhou Y, Lim KH, French M, Hoke D, Julian J, Carson DD

Human cytotrophoblast differentiation/invasion is abnormal in pre-eclampsia.

The American journal of pathology

Lim KH, Zhou Y, Janatpour M, McMaster M, Bass K, Chun SH, Fisher SJ

Elevated nonesterified fatty acid concentrations in severe preeclampsia shift the isoelectric characteristics of plasma albumin.

The Journal of clinical endocrinology and metabolism

Vigne JL, Murai JT, Arbogast BW, Jia W, Fisher SJ, Taylor RN

Regulation of human placental development by oxygen tension.

Science (New York, N.Y.)

Genbacev O, Zhou Y, Ludlow JW, Fisher SJ

Identification of a thymic epithelial cell subset sharing expression of the class Ib HLA-G molecule with fetal trophoblasts.

The Journal of experimental medicine

Crisa L, McMaster MT, Ishii JK, Fisher SJ, Salomon DR

Palmitoyl carnitine, a lysophospholipase-transacylase inhibitor, prevents Candida adherence in vitro.

FEMS microbiology letters

Prakobphol A, Leffler H, Hoover CI, Fisher SJ

Human cytotrophoblasts adopt a vascular phenotype as they differentiate. A strategy for successful endovascular invasion?

The Journal of clinical investigation

Zhou Y, Fisher SJ, Janatpour M, Genbacev O, Dejana E, Wheelock M, Damsky CH

The solid state environment orchestrates embryonic development and tissue remodeling.

Kidney international

Damsky CH, Moursi A, Zhou Y, Fisher SJ, Globus RK

Tissue inhibitor of metalloproteinase-3 expression is upregulated during human cytotrophoblast invasion in vitro.

Developmental genetics

Bass KE, Li H, Hawkes SP, Howard E, Bullen E, Vu TK, McMaster M, Janatpour M, Fisher SJ

Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10.

The Journal of experimental medicine

Roth I, Corry DB, Locksley RM, Abrams JS, Litton MJ, Fisher SJ

PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins.

American journal of human genetics

Azen EA, Amberger E, Fisher S, Prakobphol A, Niece RL

Conference report: placental growth and function.

Placenta

Challis JR, Andres SF, Catz CS, Fisher SJ, Hay WW, Hunt JS, Illsley NP, Thornburg KL

Maternal smoking inhibits early human cytotrophoblast differentiation.

Reproductive toxicology (Elmsford, N.Y.)

Genbacev O, Bass KE, Joslin RJ, Fisher SJ

Quantifying the strength of bacterial adhesive interactions with salivary glycoproteins.

Journal of dental research

Prakobphol A, Burdsal CA, Fisher SJ

Human placental HLA-G expression is restricted to differentiated cytotrophoblasts.

Journal of immunology (Baltimore, Md. : 1950)

McMaster MT, Librach CL, Zhou Y, Lim KH, Janatpour MJ, DeMars R, Kovats S, Damsky C, Fisher SJ

Implantation and the placenta: key pieces of the development puzzle.

Science (New York, N.Y.)

Cross JC, Werb Z, Fisher SJ

Integrin switching regulates normal trophoblast invasion.

Development (Cambridge, England)

Damsky CH, Librach C, Lim KH, Fitzgerald ML, McMaster MT, Janatpour M, Zhou Y, Logan SK, Fisher SJ

Glycosylation of human trophoblast integrins is stage and cell-type specific.

Glycobiology

Moss L, Prakobphol A, Wiedmann TW, Fisher SJ, Damsky CH

Human trophoblast invasion. Autocrine control and paracrine modulation.

Annals of the New York Academy of Sciences

McMaster MT, Bass KE, Fisher SJ

Specific adherence of Candida tropicalis to lysophospholipids.

Biochemistry

Prakobphol A, Leffler H, Fisher SJ

Human cytotrophoblast invasion is up-regulated by epidermal growth factor: evidence that paracrine factors modify this process.

Developmental biology

Bass KE, Morrish D, Roth I, Bhardwaj D, Taylor R, Zhou Y, Fisher SJ

Interleukin-1 beta regulates human cytotrophoblast metalloproteinase activity and invasion in vitro.

The Journal of biological chemistry

Librach CL, Feigenbaum SL, Bass KE, Cui TY, Verastas N, Sadovsky Y, Quigley JP, French DL, Fisher SJ

Increased depth of trophoblast invasion after chronic constriction of the lower aorta in rhesus monkeys.

American journal of obstetrics and gynecology

Zhou Y, Chiu K, Brescia RJ, Combs CA, Katz MA, Kitzmiller JL, Heilbron DC, Fisher SJ

Human cytotrophoblast invasion.

Seminars in cell biology

Fisher SJ, Damsky CH

Preeclampsia is associated with abnormal expression of adhesion molecules by invasive cytotrophoblasts.

The Journal of clinical investigation

Zhou Y, Damsky CH, Chiu K, Roberts JM, Fisher SJ

The high-molecular-weight human mucin is the primary salivary carrier of ABH, Le(a), and Le(b) blood group antigens.

Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists

Prakobphol A, Leffler H, Fisher SJ

Adherence of oral streptococci to salivary glycoproteins.

Infection and immunity

Murray PA, Prakobphol A, Lee T, Hoover CI, Fisher SJ

An inhibitor of the matrix metalloproteinase synthesized by rabbit corneal epithelium.

Investigative ophthalmology & visual science

Fini ME, Cui TY, Mouldovan A, Grobelny D, Galardy RE, Fisher SJ

Structure and bacterial receptor activity of a human salivary proline-rich glycoprotein.

The Journal of biological chemistry

Gillece-Castro BL, Prakobphol A, Burlingame AL, Leffler H, Fisher SJ

92-kD type IV collagenase mediates invasion of human cytotrophoblasts.

The Journal of cell biology

Librach CL, Werb Z, Fitzgerald ML, Chiu K, Corwin NM, Esteves RA, Grobelny D, Galardy R, Damsky CH, Fisher SJ

Effect of plasma on composition of human enamel and cementum pellicle.

Scandinavian journal of dental research

Kajisa L, Prakobphol A, Schiödt M, Fisher SJ

A class I antigen, HLA-G, expressed in human trophoblasts.

Science (New York, N.Y.)

Kovats S, Main EK, Librach C, Stubblebine M, Fisher SJ, DeMars R

Adhesive and degradative properties of human placental cytotrophoblast cells in vitro.

The Journal of cell biology

Fisher SJ, Cui TY, Zhang L, Hartman L, Grahl K, Zhang GY, Tarpey J, Damsky CH

Structure and heterogeneity of the oligosaccharides from the lipopolysaccharides of a pyocin-resistant Neisseria gonorrhoeae.

Proceedings of the National Academy of Sciences of the United States of America

Gibson BW, Webb JW, Yamasaki R, Fisher SJ, Burlingame AL, Mandrell RE, Schneider H, Griffiss JM

Structural characterization of intact, branched oligosaccharides by high performance liquid chromatography and liquid secondary ion mass spectrometry.

Analytical biochemistry

Webb JW, Jiang K, Gillece-Castro BL, Tarentino AL, Plummer TH, Byrd JC, Fisher SJ, Burlingame AL

Bacterial adherence on replicas of sodium dodecyl sulfate-polyacrylamide gels.

Analytical biochemistry

Prakobphol A, Murray PA, Fisher SJ

Structure of the oligosaccharide portion of human hepatitis B surface antigen.

Archives of biochemistry and biophysics

Gillece-Castro BL, Fisher SJ, Tarentino AL, Peterson DL, Burlingame AL

External radiolabelling of components of pellicle on human enamel and cementum.

Archives of oral biology

Fisher SJ, Prakobphol A, Kajisa L, Murray PA

Preparation of placental (fetal tissue) fibronectin and its carbohydrates.

Methods in enzymology

Laine RA, Fisher SJ, Zhu BC

Degradation of extracellular matrix by the trophoblastic cells of first-trimester human placentas.

Journal of cellular biochemistry

Fisher SJ, Leitch MS, Kantor MS, Basbaum CB, Kramer RH

Characterization of oral streptococci that activate the dietary glycoside rutin to a mutagen.

Journal of the National Cancer Institute

Shillitoe EJ, Hoover CI, Fisher SJ, Abdel-Salam M, Greenspan JS

External labelling of glycoproteins from first-trimester human placental microvilli.

The Biochemical journal

Fisher SJ, Leitch MS, Laine RA

Carbohydrate structure of the major glycopeptide from human cold-insoluble globulin.

Journal of supramolecular structure

Fisher SJ, Laine RA