Professor Emeritus
P_Bioengineering
+1 415 476-1159
The overarching goal of the Kroetz laboratory is to understand the molecular basis of interindividual variability in drug response and toxicity. Genomic association studies are used to identify genes and pathways involved in common toxicities associated with cancer therapy, including taxane-induced peripheral neuropathy and bevacizumab-induced hypertension. Functional genomic studies are then used to define the role of these genes and pathways in the dose-limiting toxicities. A second area of research is on the role of ABC transporters in drug resistance and physiologic function. Ongoing efforts include cryo-EM studies of MRP4 and investigation of MRP4 in resistance to immunotherapy.
Publications
Modeling mechanisms of chemotherapy-induced peripheral neuropathy and chemotherapy transport using induced pluripotent stem cell-derived sensory neurons.
Neuropharmacology
Structural basis of prostaglandin efflux by MRP4.
Nature structural & molecular biology
New and emerging research on solute carrier (SLC) and ABC transporters in drug discovery and development: Outlook from the International Transporter Consortium.
Clinical pharmacology and therapeutics
Correction: Bevacizumab-induced hypertension and proteinuria: a genome-wide study of more than 1000 patients.
British journal of cancer
Bevacizumab-induced hypertension and proteinuria: a genome-wide study of more than 1000 patients.
British journal of cancer
Mechanistic Insights into the Pathogenesis of Microtubule Targeting Agent-Induced Peripheral Neuropathy from Pharmacogenetic and Functional Studies.
Basic & clinical pharmacology & toxicology
In-depth triacylglycerol profiling using MS3 Q-Trap mass spectrometry.
Analytica chimica acta
Human Induced Pluripotent Stem Cell Derived Sensory Neurons are Sensitive to the Neurotoxic Effects of Paclitaxel.
Clinical and translational science
GSTP1 and ABCB1 Polymorphisms Predicting Toxicities and Clinical Management on Carboplatin and Paclitaxel-Based Chemotherapy in Ovarian Cancer.
Clinical and translational science
Role for Drug Transporters in Chemotherapy-Induced Peripheral Neuropathy.
Clinical and translational science
Genome-Wide Meta-Analysis Validates a Role for S1PR1 in Microtubule Targeting Agent-Induced Sensory Peripheral Neuropathy.
Clinical pharmacology and therapeutics
P-glycoprotein Inhibition Exacerbates Paclitaxel Neurotoxicity in Neurons and Cancer Patients.
Clinical pharmacology and therapeutics
Reversible Inhibition of Efflux Transporters by Hydrogel Microdevices.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Efficient estimation of grouped survival models.
BMC bioinformatics
Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug-Drug Interaction and Associated Biomarker Levels in Healthy Volunteers.
Clinical and translational science
Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing.
The Journal of pharmacology and experimental therapeutics
A Practical First Step Using Needs Assessment and a Survey Approach to Implementing a Clinical Pharmacogenomics Consult Service.
Journal of the American College of Clinical Pharmacy : JAACP
A Pharmacogenetic Prediction Model of Progression-Free Survival in Breast Cancer using Genome-Wide Genotyping Data from CALGB 40502 (Alliance).
Clinical pharmacology and therapeutics
Tumor Drug Penetration Measurements Could Be the Neglected Piece of the Personalized Cancer Treatment Puzzle.
Clinical pharmacology and therapeutics
CYP2B6 Genetic Polymorphisms, Depression, and Viral Suppression in Adults Living with HIV Initiating Efavirenz-Containing Antiretroviral Therapy Regimens in Uganda: Pooled Analysis of Two Prospective Studies.
AIDS research and human retroviruses
Identification of a Genomic Region between SLC29A1 and HSP90AB1 Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance).
Clinical cancer research : an official journal of the American Association for Cancer Research
Rare Variants in the ABCG2 Promoter Modulate In Vivo Activity.
Drug metabolism and disposition: the biological fate of chemicals
Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci.
Pharmacogenetics and genomics
Dicloxacillin induces CYP2C19, CYP2C9 and CYP3A4 in vivo and in vitro.
British journal of clinical pharmacology
Clinical Pharmacokinetics of Paclitaxel Monotherapy: An Updated Literature Review.
Clinical pharmacokinetics
ABCG2 regulatory single-nucleotide polymorphisms alter in vivo enhancer activity and expression.
Pharmacogenetics and genomics
Bevacizumab-induced hypertension: Clinical presentation and molecular understanding.
Pharmacology & therapeutics
Genetic advances uncover mechanisms of chemotherapy-induced peripheral neuropathy.
Clinical pharmacology and therapeutics
In Vivo Hepatic Enhancer Elements in the Human ABCG2 Locus.
Drug metabolism and disposition: the biological fate of chemicals
ABC transporter polymorphisms are associated with irinotecan pharmacokinetics and neutropenia.
The pharmacogenomics journal
Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1.
Clinical pharmacology and therapeutics
Best Practices for Clinical and Translational Research and Implementation.
Clinical and translational science
Host genetic predictors of the kynurenine pathway of tryptophan catabolism among treated HIV-infected Ugandans.
AIDS (London, England)
Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy.
Clinical cancer research : an official journal of the American Association for Cancer Research
Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines.
The pharmacogenomics journal
Transforming Translation: Impact of Clinical and Translational Science.
Clinical and translational science
Pharmacoethnicity in Paclitaxel-Induced Sensory Peripheral Neuropathy.
Clinical cancer research : an official journal of the American Association for Cancer Research
PharmGKB summary: very important pharmacogene information for human leukocyte antigen B.
Pharmacogenetics and genomics
SOX11 identified by target gene evaluation of miRNAs differentially expressed in focal and non-focal brain tissue of therapy-resistant epilepsy patients.
Neurobiology of disease
Genomic architecture of pharmacological efficacy and adverse events.
Pharmacogenomics
PharmGKB summary: abacavir pathway.
Pharmacogenetics and genomics
Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing: 2014 update.
Clinical pharmacology and therapeutics
Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).
The pharmacogenomics journal
Expression of six drug transporters in vaginal, cervical, and colorectal tissues: Implications for drug disposition in HIV prevention.
Journal of clinical pharmacology
Response to "CYP2C9 polymorphism is not a major determinant of bosentan exposure in healthy volunteers".
Clinical pharmacology and therapeutics
Measuring the overall genetic component of nevirapine pharmacokinetics and the role of selected polymorphisms: towards addressing the missing heritability in pharmacogenetic phenotypes?
Pharmacogenetics and genomics
ABCC4 is regulated by microRNA-124a and microRNA-506.
Biochemical pharmacology
Epoxyeicosatrienoic acids prevent cisplatin-induced renal apoptosis through a p38 mitogen-activated protein kinase-regulated mitochondrial pathway.
Molecular pharmacology
Genome-wide association studies in pharmacogenomics: successes and lessons.
Pharmacogenetics and genomics
Association of CYP2C9*2 with bosentan-induced liver injury.
Clinical pharmacology and therapeutics
OATP1B1-related drug-drug and drug-gene interactions as potential risk factors for cerivastatin-induced rhabdomyolysis.
Pharmacogenetics and genomics
The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance).
Pharmacogenetics and genomics
Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy.
Clinical cancer research : an official journal of the American Association for Cancer Research
Re: CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the Breast International Group 1-98 trial.
Journal of the National Cancer Institute
A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101.
Clinical cancer research : an official journal of the American Association for Cancer Research
In vitro metabolism of piperaquine is primarily mediated by CYP3A4.
Xenobiotica; the fate of foreign compounds in biological systems
Functional characterization of ABCC2 promoter polymorphisms and allele-specific expression.
The pharmacogenomics journal
Attenuation of cisplatin-induced renal injury by inhibition of soluble epoxide hydrolase involves nuclear factor ?B signaling.
The Journal of pharmacology and experimental therapeutics
Clinical pharmacogenetics implementation consortium guidelines for HLA-B genotype and abacavir dosing.
Clinical pharmacology and therapeutics
Contribution of aquaporin 9 and multidrug resistance-associated protein 2 to differential sensitivity to arsenite between primary cultured chorion and amnion cells prepared from human fetal membranes.
Toxicology and applied pharmacology
Cerivastatin, genetic variants, and the risk of rhabdomyolysis.
Pharmacogenetics and genomics
Discovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait mapping.
The pharmacogenomics journal
Functional characterization of liver enhancers that regulate drug-associated transporters.
Clinical pharmacology and therapeutics
Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein).
Pharmacogenetics and genomics
Exploiting the complexity of the genome and transcriptome using pharmacogenomics towards personalized medicine.
Genome biology
Functional hot spots in human ATP-binding cassette transporter nucleotide binding domains.
Protein science : a publication of the Protein Society
Polymorphic variants in the human bile salt export pump (BSEP; ABCB11): functional characterization and interindividual variability.
Pharmacogenetics and genomics
The pharmacogenomics of membrane transporters project: research at the interface of genomics and transporter pharmacology.
Clinical pharmacology and therapeutics
Institutional Profile: The University of California Pharmacogenomics Center: at the interface of genomics, biological mechanisms and drug therapy.
Pharmacogenomics
A survey of integral alpha-helical membrane proteins.
Journal of structural and functional genomics
Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Inhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammation.
The Journal of pharmacology and experimental therapeutics
Nicotine metabolism in pregnant and nonpregnant rabbits.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene.
The Journal of pharmacology and experimental therapeutics
Substrate-dependent effects of human ABCB1 coding polymorphisms.
The Journal of pharmacology and experimental therapeutics
The effects of ABCB1 3'-untranslated region variants on mRNA stability.
Drug metabolism and disposition: the biological fate of chemicals
Interindividual variability in the effect of atazanavir and saquinavir on the expression of lymphocyte P-glycoprotein.
The Journal of antimicrobial chemotherapy
Adherence-resistance relationships to combination HIV antiretroviral therapy.
Current HIV/AIDS reports
Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha.
Drug metabolism and disposition: the biological fate of chemicals
Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa.
Clinical pharmacology and therapeutics
Function-altering SNPs in the human multidrug transporter gene ABCB1 identified using a Saccharomyces-based assay.
PLoS genetics
The pharmacogenetics research network: from SNP discovery to clinical drug response.
Clinical pharmacology and therapeutics
ABCB1 pharmacogenetics: progress, pitfalls, and promise.
Clinical pharmacology and therapeutics
Irinotecan-induced diarrhea: functional significance of the polymorphic ABCC2 transporter protein.
Clinical pharmacology and therapeutics
Inhibition of smooth muscle proliferation by urea-based alkanoic acids via peroxisome proliferator-activated receptor alpha-dependent repression of cyclin D1.
Arteriosclerosis, thrombosis, and vascular biology
Role for drug transporters beyond tumor resistance: hepatic functional imaging and genotyping of multidrug resistance transporters for the prediction of irinotecan toxicity.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
CYP4 isoform specificity in the omega-hydroxylation of phytanic acid, a potential route to elimination of the causative agent of Refsum's disease.
The Journal of pharmacology and experimental therapeutics
MDR1 haplotype frequencies in Japanese and Caucasian, and in Japanese patients with colorectal cancer and esophageal cancer.
Drug metabolism and pharmacokinetics
PharmGKB submission update: IV. PMT submissions of genetic variations in ATP-Binding cassette transporters to the PharmGKB network.
Pharmacological reviews
PharmGKB submission update: V. PMT submissions of genetic variation in SLC22 family transporters.
Pharmacological reviews
PharmGKB submission update: VI. PMT submissions of genetic variations in neurotransmitter transporters (SLC6, SLC17, and SLC18) to the PharmGKB network.
Pharmacological reviews
Induction of renal cytochrome P450 arachidonic acid epoxygenase activity by dietary gamma-linolenic acid.
The Journal of pharmacology and experimental therapeutics
Drug-metabolizing enzymes: evidence for clinical utility of pharmacogenomic tests.
Clinical pharmacology and therapeutics
Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability.
Pharmacogenetics and genomics
Differential renal gene expression in prehypertensive and hypertensive spontaneously hypertensive rats.
American journal of physiology. Renal physiology
Regulation and inhibition of arachidonic acid omega-hydroxylases and 20-HETE formation.
Annual review of pharmacology and toxicology
Functional implications of genetic polymorphisms in the multidrug resistance gene MDR1 (ABCB1).
Pharmaceutical research
Vascular localization of soluble epoxide hydrolase in the human kidney.
American journal of physiology. Renal physiology
Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes.
The Journal of pharmacology and experimental therapeutics
No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects.
Clinical pharmacology and therapeutics
Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene.
Pharmacogenetics
Natural variation in human membrane transporter genes reveals evolutionary and functional constraints.
Proceedings of the National Academy of Sciences of the United States of America
Antihypertensive effect of mechanism-based inhibition of renal arachidonic acid omega-hydroxylase activity.
American journal of physiology. Regulatory, integrative and comparative physiology
MDR1 reference sequence and reference function.
Clinical pharmacology and therapeutics
Cytochrome P450 pathways of arachidonic acid metabolism.
Current opinion in lipidology
Candidate gene approach for pharmacogenetic studies.
Pharmacogenomics
Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids.
Circulation research
Increased CYP2J expression and epoxyeicosatrienoic acid formation in spontaneously hypertensive rat kidney.
Molecular pharmacology
Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression system.
Drug metabolism and disposition: the biological fate of chemicals
Structure activity relationship of human microsomal epoxide hydrolase inhibition by amide and acid analogues of valproic acid.
Pharmaceutical research
Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylases.
Archives of biochemistry and biophysics
The effects of a diet rich in docosahexaenoic acid on organ and vascular fatty acid composition in spontaneously hypertensive rats.
Prostaglandins, leukotrienes, and essential fatty acids
Docosahexaenoic acid is an antihypertensive nutrient that affects aldosterone production in SHR.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Peroxisome proliferator-activated receptor alpha controls the hepatic CYP4A induction adaptive response to starvation and diabetes.
The Journal of biological chemistry
Structure-function relationships of human liver cytochromes P450 3A: aflatoxin B1 metabolism as a probe.
Biochemistry
Inhibition of renal arachidonic acid omega-hydroxylase activity with ABT reduces blood pressure in the SHR.
The American journal of physiology
Developmentally regulated expression of the CYP4A genes in the spontaneously hypertensive rat kidney.
Molecular pharmacology
Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators.
Molecular and cellular biology
Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation.
Biochemical pharmacology
In vivo and in vitro correlation of microsomal epoxide hydrolase inhibition by progabide.
Clinical pharmacology and therapeutics
Carbamazepine-valnoctamide interaction in epileptic patients: in vitro/in vivo correlation.
Epilepsia
Measurement of in vivo microsomal epoxide hydrolase activity in white subjects.
Clinical pharmacology and therapeutics