Deanna Kroetz, PhD

Professor Emeritus
Bioengineering
[email protected]
+1 415 476-1159

The overarching goal of the Kroetz laboratory is to understand the molecular basis of interindividual variability in drug response and toxicity. Genomic association studies are used to identify genes and pathways involved in common toxicities associated with cancer therapy, including taxane-induced peripheral neuropathy and bevacizumab-induced hypertension. Functional genomic studies are then used to define the role of these genes and pathways in the dose-limiting toxicities. A second area of research is on the role of ABC transporters in drug resistance and physiologic function. Ongoing efforts include cryo-EM studies of MRP4 and investigation of MRP4 in resistance to immunotherapy.

Publications: 

Modeling mechanisms of chemotherapy-induced peripheral neuropathy and chemotherapy transport using induced pluripotent stem cell-derived sensory neurons.

Neuropharmacology

Mortensen C, Thomsen MT, Chua KC, Hammer HS, Nielsen F, Pötz O, Svenningsen AF, Kroetz DL, Stage TB

Effect of Antioxidants in Medicinal Products on Intestinal Drug Transporters.

Pharmaceutics

Kulkarni CP, Yang J, Koleske ML, Lara G, Alam K, Raw A, Rege B, Zhao L, Lu D, Zhang L, Yu LX, Lionberger RA, Giacomini KM, Kroetz DL, Yee SW

Structural basis of prostaglandin efflux by MRP4.

Nature structural & molecular biology

Pourmal S, Green E, Bajaj R, Chemmama IE, Knudsen GM, Gupta M, Sali A, Cheng Y, Craik CS, Kroetz DL, Stroud RM

Host variation in type I interferon signaling genes (MX1), C-C chemokine receptor type 5 gene, and major histocompatibility complex class I alleles in treated HIV+ noncontrollers predict viral reservoir size.

AIDS (London, England)

Siegel DA, Thanh C, Wan E, Hoh R, Hobbs K, Pan T, Gibson EA, Kroetz DL, Martin J, Hecht F, Pilcher C, Martin M, Carrington M, Pillai S, Busch MP, Stone M, Levy CN, Huang ML, Roychoudhury P, Hladik F, Jerome KR, Kiem HP, Henrich TJ, Deeks SG, Lee SA

New and emerging research on solute carrier (SLC) and ABC transporters in drug discovery and development: Outlook from the International Transporter Consortium.

Clinical pharmacology and therapeutics

Giacomini KM, Yee SW, Koleske ML, Zou L, Matsson P, Chen E, Kroetz DL, Miller MA, Gozalpour E, Chu X

Correction: Bevacizumab-induced hypertension and proteinuria: a genome-wide study of more than 1000 patients.

British journal of cancer

Quintanilha JCF, Wang J, Sibley AB, Jiang C, Etheridge AS, Shen F, Jiang G, Mulkey F, Patel JN, Hertz DL, Dees EC, McLeod HL, Bertagnolli M, Rugo H, Kindler HL, Kelly WK, Ratain MJ, Kroetz DL, Owzar K, Schneider BP, Lin D, Innocenti F

Bevacizumab-induced hypertension and proteinuria: a genome-wide study of more than 1000 patients.

British journal of cancer

Quintanilha JCF, Wang J, Sibley AB, Jiang C, Etheridge AS, Shen F, Jiang G, Mulkey F, Patel JN, Hertz DL, Dees EC, McLeod HL, Bertagnolli M, Rugo H, Kindler HL, Kelly WK, Ratain MJ, Kroetz DL, Owzar K, Schneider BP, Lin D, Innocenti F

Interaction of Commonly Used Oral Molecular Excipients with P-glycoprotein.

The AAPS journal

Bajaj R, Chong LB, Zou L, Tsakalozou E, Ni Z, Giacomini KM, Kroetz DL

In-depth triacylglycerol profiling using MS3 Q-Trap mass spectrometry.

Analytica chimica acta

Cabruja M, Priotti J, Domizi P, Papsdorf K, Kroetz DL, Brunet A, Contrepois K, Snyder MP

Human Induced Pluripotent Stem Cell Derived Sensory Neurons are Sensitive to the Neurotoxic Effects of Paclitaxel.

Clinical and translational science

Xiong C, Chua KC, Stage TB, Priotti J, Kim J, Altman-Merino A, Chan D, Saraf K, Canato Ferracini A, Fattahi F, Kroetz DL

GSTP1 and ABCB1 Polymorphisms Predicting Toxicities and Clinical Management on Carboplatin and Paclitaxel-Based Chemotherapy in Ovarian Cancer.

Clinical and translational science

Ferracini AC, Lopes-Aguiar L, Lourenço GJ, Yoshida A, Lima CSP, Sarian LO, Derchain S, Kroetz DL, Mazzola PG

Role for Drug Transporters in Chemotherapy-Induced Peripheral Neuropathy.

Clinical and translational science

Stage TB, Hu S, Sparreboom A, Kroetz DL

Genome-Wide Meta-Analysis Validates a Role for S1PR1 in Microtubule Targeting Agent-Induced Sensory Peripheral Neuropathy.

Clinical pharmacology and therapeutics

Chua KC, Xiong C, Ho C, Mushiroda T, Jiang C, Mulkey F, Lai D, Schneider BP, Rashkin SR, Witte JS, Friedman PN, Ratain MJ, McLeod HL, Rugo HS, Shulman LN, Kubo M, Owzar K, Kroetz DL

P-glycoprotein Inhibition Exacerbates Paclitaxel Neurotoxicity in Neurons and Cancer Patients.

Clinical pharmacology and therapeutics

Stage TB, Mortensen C, Khalaf S, Steffensen V, Hammer HS, Xiong C, Nielsen F, Poetz O, Svenningsen ÅF, Rodriguez-Antona C, Kroetz DL

Reversible Inhibition of Efflux Transporters by Hydrogel Microdevices.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

Levy ES, Samy KE, Lamson NG, Whitehead KA, Kroetz DL, Desai TA

Efficient estimation of grouped survival models.

BMC bioinformatics

Li Z, Lin J, Sibley AB, Truong T, Chua KC, Jiang Y, McCarthy J, Kroetz DL, Allen A, Owzar K

Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug-Drug Interaction and Associated Biomarker Levels in Healthy Volunteers.

Clinical and translational science

Yee SW, Giacomini MM, Shen H, Humphreys WG, Horng H, Brian W, Lai Y, Kroetz DL, Giacomini KM

Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing.

The Journal of pharmacology and experimental therapeutics

Jayagopal A, Brakeman PR, Soler P, Ferrell N, Fissell W, Kroetz DL, Roy S

A Practical First Step Using Needs Assessment and a Survey Approach to Implementing a Clinical Pharmacogenomics Consult Service.

Journal of the American College of Clinical Pharmacy : JAACP

Zakinova A, Long-Boyle JR, French D, Croci R, Wilson L, Phillips KA, Kroetz DL, Shin J, Tamraz B

A Pharmacogenetic Prediction Model of Progression-Free Survival in Breast Cancer using Genome-Wide Genotyping Data from CALGB 40502 (Alliance).

Clinical pharmacology and therapeutics

Rashkin SR, Chua KC, Ho C, Mulkey F, Jiang C, Mushiroda T, Kubo M, Friedman PN, Rugo HS, McLeod HL, Ratain MJ, Castillos F, Naughton M, Overmoyer B, Toppmeyer D, Witte JS, Owzar K, Kroetz DL

Tumor Drug Penetration Measurements Could Be the Neglected Piece of the Personalized Cancer Treatment Puzzle.

Clinical pharmacology and therapeutics

Bartelink IH, Jones EF, Shahidi-Latham SK, Lee PRE, Zheng Y, Vicini P, van 't Veer L, Wolf D, Iagaru A, Kroetz DL, Prideaux B, Cilliers C, Thurber GM, Wimana Z, Gebhart G

CYP2B6 Genetic Polymorphisms, Depression, and Viral Suppression in Adults Living with HIV Initiating Efavirenz-Containing Antiretroviral Therapy Regimens in Uganda: Pooled Analysis of Two Prospective Studies.

AIDS research and human retroviruses

Chang JL, Lee SA, Tsai AC, Musinguzi N, Muzoora C, Bwana B, Boum Y, Haberer JE, Hunt PW, Martin J, Bangsberg DR, Kroetz DL, Siedner MJ

Identification of a Genomic Region between SLC29A1 and HSP90AB1 Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance).

Clinical cancer research : an official journal of the American Association for Cancer Research

Li M, Mulkey F, Jiang C, O'Neil BH, Schneider BP, Shen F, Friedman PN, Momozawa Y, Kubo M, Niedzwiecki D, Hochster HS, Lenz HJ, Atkins JN, Rugo HS, Halabi S, Kelly WK, McLeod HL, Innocenti F, Ratain MJ, Venook AP, Owzar K, Kroetz DL

Rare Variants in the ABCG2 Promoter Modulate In Vivo Activity.

Drug metabolism and disposition: the biological fate of chemicals

Eclov RJ, Kim MJ, Smith R, Ahituv N, Kroetz DL

Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci.

Pharmacogenetics and genomics

Sucheston-Campbell LE, Clay-Gilmour AI, Barlow WE, Budd GT, Stram DO, Haiman CA, Sheng X, Yan L, Zirpoli G, Yao S, Jiang C, Owzar K, Hershman D, Albain KS, Hayes DF, Moore HC, Hobday TJ, Stewart JA, Rizvi A, Isaacs C, Salim M, Gralow JR, Hortobagyi GN, Livingston RB, Kroetz DL, Ambrosone CB

Dicloxacillin induces CYP2C19, CYP2C9 and CYP3A4 in vivo and in vitro.

British journal of clinical pharmacology

Stage TB, Graff M, Wong S, Rasmussen LL, Nielsen F, Pottegård A, Brøsen K, Kroetz DL, Khojasteh SC, Damkier P

Clinical Pharmacokinetics of Paclitaxel Monotherapy: An Updated Literature Review.

Clinical pharmacokinetics

Stage TB, Bergmann TK, Kroetz DL

ABCG2 regulatory single-nucleotide polymorphisms alter in vivo enhancer activity and expression.

Pharmacogenetics and genomics

Eclov RJ, Kim MJ, Chhibber A, Smith RP, Ahituv N, Kroetz DL

Genetic advances uncover mechanisms of chemotherapy-induced peripheral neuropathy.

Clinical pharmacology and therapeutics

Chua KC, Kroetz DL

In Vivo Hepatic Enhancer Elements in the Human ABCG2 Locus.

Drug metabolism and disposition: the biological fate of chemicals

Eclov RJ, Kim MJ, Smith RP, Liang X, Ahituv N, Kroetz DL

ABC transporter polymorphisms are associated with irinotecan pharmacokinetics and neutropenia.

The pharmacogenomics journal

Li M, Seiser EL, Baldwin RM, Ramirez J, Ratain MJ, Innocenti F, Kroetz DL

Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1.

Clinical pharmacology and therapeutics

Yee SW, Giacomini MM, Hsueh CH, Weitz D, Liang X, Goswami S, Kinchen JM, Coelho A, Zur AA, Mertsch K, Brian W, Kroetz DL, Giacomini KM

Host genetic predictors of the kynurenine pathway of tryptophan catabolism among treated HIV-infected Ugandans.

AIDS (London, England)

Lee SA, Mefford JA, Huang Y, Witte JS, Martin JN, Haas DW, Mclaren PJ, Mushiroda T, Kubo M, Byakwaga H, Hunt PW, Kroetz DL

Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy.

Clinical cancer research : an official journal of the American Association for Cancer Research

Hertz DL, Owzar K, Lessans S, Wing C, Jiang C, Kelly WK, Patel J, Halabi S, Furukawa Y, Wheeler HE, Sibley AB, Lassiter C, Weisman L, Watson D, Krens SD, Mulkey F, Renn CL, Small EJ, Febbo PG, Shterev I, Kroetz DL, Friedman PN, Mahoney JF, Carducci MA, Kelley MJ, Nakamura Y, Kubo M, Dorsey SG, Dolan ME, Morris MJ, Ratain MJ, McLeod HL

Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines.

The pharmacogenomics journal

Chhibber A, French CE, Yee SW, Gamazon ER, Theusch E, Qin X, Webb A, Papp AC, Wang A, Simmons CQ, Konkashbaev A, Chaudhry AS, Mitchel K, Stryke D, Ferrin TE, Weiss ST, Kroetz DL, Sadee W, Nickerson DA, Krauss RM, George AL, Schuetz EG, Medina MW, Cox NJ, Scherer SE, Giacomini KM, Brenner SE

Transforming Translation: Impact of Clinical and Translational Science.

Clinical and translational science

Wagner JA, Kroetz DL

Multidrug resistance-associated protein 4 is a determinant of arsenite resistance.

Oncology reports

Yuan B, Yoshino Y, Fukushima H, Markova S, Takagi N, Toyoda H, Kroetz DL

Pharmacoethnicity in Paclitaxel-Induced Sensory Peripheral Neuropathy.

Clinical cancer research : an official journal of the American Association for Cancer Research

Komatsu M, Wheeler HE, Chung S, Low SK, Wing C, Delaney SM, Gorsic LK, Takahashi A, Kubo M, Kroetz DL, Zhang W, Nakamura Y, Dolan ME

PharmGKB summary: very important pharmacogene information for human leukocyte antigen B.

Pharmacogenetics and genomics

Barbarino JM, Kroetz DL, Klein TE, Altman RB

SOX11 identified by target gene evaluation of miRNAs differentially expressed in focal and non-focal brain tissue of therapy-resistant epilepsy patients.

Neurobiology of disease

Haenisch S, Zhao Y, Chhibber A, Kaiboriboon K, Do LV, Vogelgesang S, Barbaro NM, Alldredge BK, Lowenstein DH, Cascorbi I, Kroetz DL

Genomic architecture of pharmacological efficacy and adverse events.

Pharmacogenomics

Chhibber A, Kroetz DL, Tantisira KG, McGeachie M, Cheng C, Plenge R, Stahl E, Sadee W, Ritchie MD, Pendergrass SA

PharmGKB summary: abacavir pathway.

Pharmacogenetics and genomics

Barbarino JM, Kroetz DL, Altman RB, Klein TE

Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing: 2014 update.

Clinical pharmacology and therapeutics

Martin MA, Hoffman JM, Freimuth RR, Klein TE, Dong BJ, Pirmohamed M, Hicks JK, Wilkinson MR, Haas DW, Kroetz DL

Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).

The pharmacogenomics journal

Chhibber A, Mefford J, Stahl EA, Pendergrass SA, Baldwin RM, Owzar K, Li M, Winer EP, Hudis CA, Zembutsu H, Kubo M, Nakamura Y, McLeod HL, Ratain MJ, Shulman LN, Ritchie MD, Plenge RM, Witte JS, Kroetz DL

Expression of six drug transporters in vaginal, cervical, and colorectal tissues: Implications for drug disposition in HIV prevention.

Journal of clinical pharmacology

Nicol MR, Fedoriw Y, Mathews M, Prince HM, Patterson KB, Geller E, Mollan K, Mathews S, Kroetz DL, Kashuba AD

Response to "CYP2C9 polymorphism is not a major determinant of bosentan exposure in healthy volunteers".

Clinical pharmacology and therapeutics

Markova SM, Schwartz JB, Kroetz DL

ABCC4 is regulated by microRNA-124a and microRNA-506.

Biochemical pharmacology

Markova SM, Kroetz DL

Genome-wide association studies in pharmacogenomics: successes and lessons.

Pharmacogenetics and genomics

Motsinger-Reif AA, Jorgenson E, Relling MV, Kroetz DL, Weinshilboum R, Cox NJ, Roden DM

Association of CYP2C9*2 with bosentan-induced liver injury.

Clinical pharmacology and therapeutics

Markova SM, De Marco T, Bendjilali N, Kobashigawa EA, Mefford J, Sodhi J, Le H, Zhang C, Halladay J, Rettie AE, Khojasteh C, McGlothlin D, Wu AH, Hsueh WC, Witte JS, Schwartz JB, Kroetz DL

OATP1B1-related drug-drug and drug-gene interactions as potential risk factors for cerivastatin-induced rhabdomyolysis.

Pharmacogenetics and genomics

Tamraz B, Fukushima H, Wolfe AR, Kaspera R, Totah RA, Floyd JS, Ma B, Chu C, Marciante KD, Heckbert SR, Psaty BM, Kroetz DL, Kwok PY

The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance).

Pharmacogenetics and genomics

Lewis LD, Miller AA, Owzar K, Bies RR, Markova S, Jiang C, Kroetz DL, Egorin MJ, McLeod HL, Ratain MJ

Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy.

Clinical cancer research : an official journal of the American Association for Cancer Research

Wheeler HE, Gamazon ER, Wing C, Njiaju UO, Njoku C, Baldwin RM, Owzar K, Jiang C, Watson D, Shterev I, Kubo M, Zembutsu H, Winer EP, Hudis CA, Shulman LN, Nakamura Y, Ratain MJ, Kroetz DL, Cox NJ, Dolan ME

Re: CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the Breast International Group 1-98 trial.

Journal of the National Cancer Institute

Nakamura Y, Ratain MJ, Cox NJ, McLeod HL, Kroetz DL, Flockhart DA

A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101.

Clinical cancer research : an official journal of the American Association for Cancer Research

Baldwin RM, Owzar K, Zembutsu H, Chhibber A, Kubo M, Jiang C, Watson D, Eclov RJ, Mefford J, McLeod HL, Friedman PN, Hudis CA, Winer EP, Jorgenson EM, Witte JS, Shulman LN, Nakamura Y, Ratain MJ, Kroetz DL

In vitro metabolism of piperaquine is primarily mediated by CYP3A4.

Xenobiotica; the fate of foreign compounds in biological systems

Lee TM, Huang L, Johnson MK, Lizak P, Kroetz D, Aweeka F, Parikh S

Functional characterization of ABCC2 promoter polymorphisms and allele-specific expression.

The pharmacogenomics journal

Nguyen TD, Markova S, Liu W, Gow JM, Baldwin RM, Habashian M, Relling MV, Ratain MJ, Kroetz DL

Attenuation of cisplatin-induced renal injury by inhibition of soluble epoxide hydrolase involves nuclear factor ?B signaling.

The Journal of pharmacology and experimental therapeutics

Liu Y, Webb HK, Fukushima H, Micheli J, Markova S, Olson JL, Kroetz DL

Ethical aspects of participation in the database of genotypes and phenotypes of the National Center for Biotechnology Information: the Cancer and Leukemia Group B Experience.

Cancer

Peppercorn J, Shapira I, Deshields T, Kroetz D, Friedman P, Spears P, Collyar DE, Shulman LN, Dressler L, Bertagnolli MM

Clinical pharmacogenetics implementation consortium guidelines for HLA-B genotype and abacavir dosing.

Clinical pharmacology and therapeutics

Martin MA, Klein TE, Dong BJ, Pirmohamed M, Haas DW, Kroetz DL

Cerivastatin, genetic variants, and the risk of rhabdomyolysis.

Pharmacogenetics and genomics

Marciante KD, Durda JP, Heckbert SR, Lumley T, Rice K, McKnight B, Totah RA, Tamraz B, Kroetz DL, Fukushima H, Kaspera R, Bis JC, Glazer NL, Li G, Austin TR, Taylor KD, Rotter JI, Jaquish CE, Kwok PY, Tracy RP, Psaty BM

Discovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait mapping.

The pharmacogenomics journal

Matsson P, Yee SW, Markova S, Morrissey K, Jenkins G, Xuan J, Jorgenson E, Kroetz DL, Giacomini KM

Functional characterization of liver enhancers that regulate drug-associated transporters.

Clinical pharmacology and therapeutics

Kim MJ, Skewes-Cox P, Fukushima H, Hesselson S, Yee SW, Ramsey LB, Nguyen L, Eshragh JL, Castro RA, Wen CC, Stryke D, Johns SJ, Ferrin TE, Kwok PY, Relling MV, Giacomini KM, Kroetz DL, Ahituv N

Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein).

Pharmacogenetics and genomics

Hodges LM, Markova SM, Chinn LW, Gow JM, Kroetz DL, Klein TE, Altman RB

Functional hot spots in human ATP-binding cassette transporter nucleotide binding domains.

Protein science : a publication of the Protein Society

Kelly L, Fukushima H, Karchin R, Gow JM, Chinn LW, Pieper U, Segal MR, Kroetz DL, Sali A

Polymorphic variants in the human bile salt export pump (BSEP; ABCB11): functional characterization and interindividual variability.

Pharmacogenetics and genomics

Ho RH, Leake BF, Kilkenny DM, Meyer Zu Schwabedissen HE, Glaeser H, Kroetz DL, Kim RB

A survey of integral alpha-helical membrane proteins.

Journal of structural and functional genomics

Kelly L, Pieper U, Eswar N, Hays FA, Li M, Roe-Zurz Z, Kroetz DL, Giacomini KM, Stroud RM, Sali A

Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict variation.

PloS one

Hesselson SE, Matsson P, Shima JE, Fukushima H, Yee SW, Kobayashi Y, Gow JM, Ha C, Ma B, Poon A, Johns SJ, Stryke D, Castro RA, Tahara H, Choi JH, Chen L, Picard N, Sjödin E, Roelofs MJ, Ferrin TE, Myers R, Kroetz DL, Kwok PY, Giacomini KM

Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Innocenti F, Kroetz DL, Schuetz E, Dolan ME, Ramírez J, Relling M, Chen P, Das S, Rosner GL, Ratain MJ

Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Mayer F, Mayer N, Chinn L, Pinsonneault RL, Kroetz D, Bainton RJ

Inhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammation.

The Journal of pharmacology and experimental therapeutics

Fife KL, Liu Y, Schmelzer KR, Tsai HJ, Kim IH, Morisseau C, Hammock BD, Kroetz DL

Nicotine metabolism in pregnant and nonpregnant rabbits.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Tutka P, Dempsey DA, Jacob P, Benowitz NL, Kroetz DL

The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene.

The Journal of pharmacology and experimental therapeutics

Abla N, Chinn LW, Nakamura T, Liu L, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Ferrin TE, Giacomini KM, Kroetz DL

Substrate-dependent effects of human ABCB1 coding polymorphisms.

The Journal of pharmacology and experimental therapeutics

Gow JM, Hodges LM, Chinn LW, Kroetz DL

The effects of ABCB1 3'-untranslated region variants on mRNA stability.

Drug metabolism and disposition: the biological fate of chemicals

Gow JM, Chinn LW, Kroetz DL

Interindividual variability in the effect of atazanavir and saquinavir on the expression of lymphocyte P-glycoprotein.

The Journal of antimicrobial chemotherapy

Chinn LW, Gow JM, Tse MM, Becker SL, Kroetz DL

Adherence-resistance relationships to combination HIV antiretroviral therapy.

Current HIV/AIDS reports

Bangsberg DR, Kroetz DL, Deeks SG

Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha.

Drug metabolism and disposition: the biological fate of chemicals

Ng VY, Huang Y, Reddy LM, Falck JR, Lin ET, Kroetz DL

Lack of support for a role for RLIP76 (RALBP1) in response to treatment or predisposition to epilepsy.

Epilepsia

Soranzo N, Kelly L, Martinian L, Burley MW, Thom M, Sali A, Kroetz DL, Goldstein DB, Sisodiya SM

Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa.

Clinical pharmacology and therapeutics

Parikh S, Ouedraogo JB, Goldstein JA, Rosenthal PJ, Kroetz DL

The pharmacogenetics research network: from SNP discovery to clinical drug response.

Clinical pharmacology and therapeutics

Giacomini KM, Brett CM, Altman RB, Benowitz NL, Dolan ME, Flockhart DA, Johnson JA, Hayes DF, Klein T, Krauss RM, Kroetz DL, McLeod HL, Nguyen AT, Ratain MJ, Relling MV, Reus V, Roden DM, Schaefer CA, Shuldiner AR, Skaar T, Tantisira K, Tyndale RF, Wang L, Weinshilboum RM, Weiss ST, Zineh I

ABCB1 pharmacogenetics: progress, pitfalls, and promise.

Clinical pharmacology and therapeutics

Chinn LW, Kroetz DL

Irinotecan-induced diarrhea: functional significance of the polymorphic ABCC2 transporter protein.

Clinical pharmacology and therapeutics

de Jong FA, Scott-Horton TJ, Kroetz DL, McLeod HL, Friberg LE, Mathijssen RH, Verweij J, Marsh S, Sparreboom A

CYP4 isoform specificity in the omega-hydroxylation of phytanic acid, a potential route to elimination of the causative agent of Refsum's disease.

The Journal of pharmacology and experimental therapeutics

Xu F, Ng VY, Kroetz DL, de Montellano PR

MDR1 haplotype frequencies in Japanese and Caucasian, and in Japanese patients with colorectal cancer and esophageal cancer.

Drug metabolism and pharmacokinetics

Komoto C, Nakamura T, Sakaeda T, Kroetz DL, Yamada T, Omatsu H, Koyama T, Okamura N, Miki I, Tamura T, Aoyama N, Kasuga M, Okumura K

PharmGKB submission update: IV. PMT submissions of genetic variations in ATP-Binding cassette transporters to the PharmGKB network.

Pharmacological reviews

Nguyen TD, Gow JM, Chinn LW, Kelly L, Jeong H, Huang CC, Stryke D, Kawamoto M, Johns SJ, Carlson E, Taylor T, Ferrin TE, Sali A, Giacomini KM, Kroetz DL

PharmGKB submission update: V. PMT submissions of genetic variation in SLC22 family transporters.

Pharmacological reviews

Shu Y, Urban TJ, Leabman MK, Fujita T, Erdman AR, Lagpacan LL, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Taylor TR, Chan W, De La Cruz M, Carlson EJ, Ferrin TE, Brett CM, Burchard EG, Herskowitz I, Kroetz DL, Giacomini KM

PharmGKB submission update: VI. PMT submissions of genetic variations in neurotransmitter transporters (SLC6, SLC17, and SLC18) to the PharmGKB network.

Pharmacological reviews

Badagnani I, Sorani M, Edwards RH, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Carlson EJ, Taylor T, Chan W, De La Cruz M, Ferrin TE, Burchard EG, Herskowitz I, Kroetz DL, Giacomini KM

Induction of renal cytochrome P450 arachidonic acid epoxygenase activity by dietary gamma-linolenic acid.

The Journal of pharmacology and experimental therapeutics

Yu Z, Ng VY, Su P, Engler MM, Engler MB, Huang Y, Lin E, Kroetz DL

Drug-metabolizing enzymes: evidence for clinical utility of pharmacogenomic tests.

Clinical pharmacology and therapeutics

Andersson T, Flockhart DA, Goldstein DB, Huang SM, Kroetz DL, Milos PM, Ratain MJ, Thummel K

Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability.

Pharmacogenetics and genomics

Wang D, Johnson AD, Papp AC, Kroetz DL, Sadée W

Differential renal gene expression in prehypertensive and hypertensive spontaneously hypertensive rats.

American journal of physiology. Renal physiology

Seubert JM, Xu F, Graves JP, Collins JB, Sieber SO, Paules RS, Kroetz DL, Zeldin DC

Regulation and inhibition of arachidonic acid omega-hydroxylases and 20-HETE formation.

Annual review of pharmacology and toxicology

Kroetz DL, Xu F

Vascular localization of soluble epoxide hydrolase in the human kidney.

American journal of physiology. Renal physiology

Yu Z, Davis BB, Morisseau C, Hammock BD, Olson JL, Kroetz DL, Weiss RH

Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes.

The Journal of pharmacology and experimental therapeutics

Xu F, Falck JR, Ortiz de Montellano PR, Kroetz DL

No effect of MDR1 C3435T variant on loperamide disposition and central nervous system effects.

Clinical pharmacology and therapeutics

Pauli-Magnus C, Feiner J, Brett C, Lin E, Kroetz DL

Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene.

Pharmacogenetics

Kroetz DL, Pauli-Magnus C, Hodges LM, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, DeYoung J, Taylor T, Carlson EJ, Herskowitz I, Giacomini KM, Clark AG

Natural variation in human membrane transporter genes reveals evolutionary and functional constraints.

Proceedings of the National Academy of Sciences of the United States of America

Leabman MK, Huang CC, DeYoung J, Carlson EJ, Taylor TR, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Urban TJ, Kroetz DL, Ferrin TE, Clark AG, Risch N, Herskowitz I, Giacomini KM

Antihypertensive effect of mechanism-based inhibition of renal arachidonic acid omega-hydroxylase activity.

American journal of physiology. Regulatory, integrative and comparative physiology

Xu F, Straub WO, Pak W, Su P, Maier KG, Yu M, Roman RJ, Ortiz De Montellano PR, Kroetz DL

MDR1 reference sequence and reference function.

Clinical pharmacology and therapeutics

Pauli-Magnus C, Kroetz DL

Cytochrome P450 pathways of arachidonic acid metabolism.

Current opinion in lipidology

Kroetz DL, Zeldin DC

Covalent attachment of the heme prosthetic group in the CYP4F cytochrome P450 family.

Biochemistry

LeBrun LA, Xu F, Kroetz DL, Ortiz de Montellano PR

Candidate gene approach for pharmacogenetic studies.

Pharmacogenomics

Ring HZ, Kroetz DL

Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids.

Circulation research

Yu Z, Xu F, Huse LM, Morisseau C, Draper AJ, Newman JW, Parker C, Graham L, Engler MM, Hammock BD, Zeldin DC, Kroetz DL

Increased CYP2J expression and epoxyeicosatrienoic acid formation in spontaneously hypertensive rat kidney.

Molecular pharmacology

Yu Z, Huse LM, Adler P, Graham L, Ma J, Zeldin DC, Kroetz DL

Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression system.

Drug metabolism and disposition: the biological fate of chemicals

Zhang L, Gorset W, Washington CB, Blaschke TF, Kroetz DL, Giacomini KM

Structure activity relationship of human microsomal epoxide hydrolase inhibition by amide and acid analogues of valproic acid.

Pharmaceutical research

Spiegelstein O, Kroetz DL, Levy RH, Yagen B, Hurst SI, Levi M, Haj-Yehia A, Bialer M

Structural determination of the substrate specificities and regioselectivities of the rat and human fatty acid omega-hydroxylases.

Archives of biochemistry and biophysics

Hoch U, Zhang Z, Kroetz DL, Ortiz de Montellano PR

The effects of a diet rich in docosahexaenoic acid on organ and vascular fatty acid composition in spontaneously hypertensive rats.

Prostaglandins, leukotrienes, and essential fatty acids

Engler MM, Engler MB, Kroetz DL, Boswell KD, Neeley E, Krassner SM

Docosahexaenoic acid is an antihypertensive nutrient that affects aldosterone production in SHR.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)

Engler MM, Engler MB, Goodfriend TL, Ball DL, Yu Z, Su P, Kroetz DL

Structure-function relationships of human liver cytochromes P450 3A: aflatoxin B1 metabolism as a probe.

Biochemistry

Wang H, Dick R, Yin H, Licad-Coles E, Kroetz DL, Szklarz G, Harlow G, Halpert JR, Correia MA

Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators.

Molecular and cellular biology

Lee SS, Pineau T, Drago J, Lee EJ, Owens JW, Kroetz DL, Fernandez-Salguero PM, Westphal H, Gonzalez FJ

Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation.

Biochemical pharmacology

Kerr BM, Thummel KE, Wurden CJ, Klein SM, Kroetz DL, Gonzalez FJ, Levy RH

In vivo and in vitro correlation of microsomal epoxide hydrolase inhibition by progabide.

Clinical pharmacology and therapeutics

Kroetz DL, Loiseau P, Guyot M, Levy RH

Carbamazepine-valnoctamide interaction in epileptic patients: in vitro/in vivo correlation.

Epilepsia

Pisani F, Haj-Yehia A, Fazio A, Artesi C, Oteri G, Perucca E, Kroetz DL, Levy RH, Bialer M

Measurement of in vivo microsomal epoxide hydrolase activity in white subjects.

Clinical pharmacology and therapeutics

Kroetz DL, Kerr BM, McFarland LV, Loiseau P, Wilensky AJ, Levy RH