Isha Jain, PhD

Assistant Investigator
Biochemistry and Biophysics
Publications: 

Coordinated transcriptional and catabolic programs support iron dependent adaptation to RAS-MAPK pathway inhibition in pancreatic cancer.

Cancer discovery

Ravichandran M, Hu J, Cai C, Ward NP, Venida A, Foakes C, Kuljanin M, Yang A, Hennessey CJ, Yang Y, Desousa BR, Rademaker G, Staes AAL, Cakir Z, Jain IH, Aguirre AJ, Mancias JD, Shen Y, DeNicola GM, Perera RM

Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells.

Science (New York, N.Y.)

Shivaraju M, Chitta UK, Grange RMH, Jain IH, Capen D, Liao L, Xu J, Ichinose F, Zapol WM, Mootha VK, Rajagopal J

Turning the Oxygen Dial: Balancing the Highs and Lows.

Trends in cell biology

Baik AH, Jain IH

Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism.

Cell

Jain IH, Calvo SE, Markhard AL, Skinner OS, To TL, Ast T, Mootha VK

Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation.

Cell metabolism

Jain IH, Zazzeron L, Goldberger O, Marutani E, Wojtkiewicz GR, Ast T, Wang H, Schleifer G, Stepanova A, Brepoels K, Schoonjans L, Carmeliet P, Galkin A, Ichinose F, Zapol WM, Mootha VK

Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome.

Proceedings of the National Academy of Sciences of the United States of America

Ferrari M, Jain IH, Goldberger O, Rezoagli E, Thoonen R, Cheng KH, Sosnovik DE, Scherrer-Crosbie M, Mootha VK, Zapol WM

Hypoxia as a therapy for mitochondrial disease.

Science (New York, N.Y.)

Jain IH, Zazzeron L, Goli R, Alexa K, Schatzman-Bone S, Dhillon H, Goldberger O, Peng J, Shalem O, Sanjana NE, Zhang F, Goessling W, Zapol WM, Mootha VK

Spatial ordering of chromosomes enhances the fidelity of chromosome partitioning in cyanobacteria.

Proceedings of the National Academy of Sciences of the United States of America

Jain IH, Vijayan V, O'Shea EK

A high resolution map of a cyanobacterial transcriptome.

Genome biology

Vijayan V, Jain IH, O'Shea EK

The making of a young scientist.

Developmental dynamics : an official publication of the American Association of Anatomists

Jain I, Iovine K

Connexin43 (GJA1) is required in the population of dividing cells during fin regeneration.

Developmental biology

Hoptak-Solga AD, Nielsen S, Jain I, Thummel R, Hyde DR, Iovine MK

Bone growth in zebrafish fins occurs via multiple pulses of cell proliferation.

Developmental dynamics : an official publication of the American Association of Anatomists

Jain I, Stroka C, Yan J, Huang WM, Iovine MK