Mary Helen Barcellos-Hoff, PhD

Professor
Radiation Oncology
+1 415 476-8091

The Barcellos-Hoff laboratory studies radiation carcinogenesis and biologically augmented radiotherapy. In studies funded by DOE and NASA, she describe the complexity of radiation effects on biological systems and identified new mechanisms underlying radiation carcinogenesis. Translational research based on aspects of these low dose radiation studies provided new insights into the role of transforming growth factor beta (TGFß) in genomic stability and the DNA damage response and a rationale for implementing TGFß inhibition during radiotherapy. Her research shows that radiation-induced activation of TGFß mediates cancer cell response to genotoxic therapy, affects malignant cell phenotypes, alters the composition of the tumor microenvironment, and inhibits immunological responses that could eliminate cancer. Detailed understanding of how TGFß opposes effective cancer therapy are necessary for identifying patients who could benefit from TGFß inhibitors.

Dr. Barcellos-Hoff received an undergraduate degree from the University of Chicago and earned a doctoral degree in experimental pathology from the University of California, San Francisco. She conducted postdoctoral research on extracellular matrix mediated functional differentiation with Mina Bissell at the Lawrence Berkeley National Laboratory (LBNL). She joined LBNL as a staff scientist, where she rose from postdoctoral fellow to Senior Scientist and Associate Director of the Life Sciences Division. She joined New York University School of Medicine in 2008 as Director of Radiation Biology in the Department of Radiation Oncology. In 2015, he moved to UCSF as Professor and Vice Chair of Research in the Department of Radiation Oncology.

Publications: 

Validation of anti-correlated TGFβ signaling and alternative end-joining DNA repair signatures that predict response to genotoxic cancer therapy.

Clinical cancer research : an official journal of the American Association for Cancer Research

Guix I, Liu Q, Pujana MA, Ha P, Piulats J, Linares I, Guedea F, Mao JH, Lazar A, Chapman J, Yom SS, Ashworth A, Barcellos-Hoff MH

SRSF1 governs progenitor-specific alternative splicing to maintain adult epithelial tissue homeostasis and renewal.

Developmental cell

Yu T, Cazares O, Tang AD, Kim HY, Wald T, Verma A, Liu Q, Barcellos-Hoff MH, Floor SN, Jung HS, Brooks AN, Klein OD

From Mouse to Human: Cellular Morphometric Subtype Learned From Mouse Mammary Tumors Provides Prognostic Value in Human Breast Cancer.

Frontiers in oncology

Chang H, Yang X, Moore J, Liu XP, Jen KY, Snijders AM, Ma L, Chou W, Corchado-Cobos R, García-Sancha N, Mendiburu-Eliçabe M, Pérez-Losada J, Barcellos-Hoff MH, Mao JH

The Radiobiology of TGFβ.

Seminars in cancer biology

Barcellos-Hoff MH

Dual inhibition of TGF-β and PD-L1: a novel approach to cancer treatment.

Molecular oncology

Gulley JL, Schlom J, Barcellos-Hoff MH, Wang XJ, Seoane J, Audhuy F, Lan Y, Dussault I, Moustakas A

Exploiting Canonical TGFβ Signaling in Cancer Treatment.

Molecular cancer therapeutics

Liu Q, Chen G, Moore J, Guix I, Placantonokis D, Barcellos-Hoff MH

Altered regulation of BRCA1 exon 11 splicing is associated with breast cancer risk in carriers of BRCA1 pathogenic variants.

Human mutation

Ruiz de Garibay G, Fernandez-Garcia I, Mazoyer S, Leme de Calais F, Ameri P, Vijayakumar S, Martinez-Ruiz H, Damiola F, Barjhoux L, Thomassen M, Andersen LVB, Herranz C, Mateo F, Palomero L, Espín R, Gómez A, García N, Jimenez D, Bonifaci N, Extremera AI, Castaño J, Raya A, Eyras E, Puente XS, Brunet J, Lázaro C, GEMO , CIMBA , Radice P, Barnes DR, Antoniou AC, Spurdle AB, de la Hoya M, Baralle D, Barcellos-Hoff MH, Pujana MA

Editorial: Cell Signaling Mediating Critical Radiation Responses.

Frontiers in oncology

Herskind C, Barcellos-Hoff MH

Inflammation mediates the development of aggressive breast cancer following radiotherapy.

Clinical cancer research : an official journal of the American Association for Cancer Research

Ma L, Gonzalez-Junca A, Zheng Y, Ouyang H, Illa-Bochaca I, Horst KC, Krings G, Wang Y, Fernandez-Garcia I, Chou W, Barcellos-Hoff MH

In Memoriam - Zena Werb 1945-2020.

Journal of mammary gland biology and neoplasia

Barcellos-Hoff MH, Weaver VM

Positron Emission Tomography Imaging of Functional TGFß Activity and Benefit of TGFß Inhibition in Irradiated Intracranial Tumors.

International journal of radiation oncology, biology, physics

Gonzalez-Junca A, Reiners O, Borrero-Garcia LD, Beckford-Vera D, Lazar AA, Chou W, Braunstein S, VanBrocklin H, Franc BL, Barcellos-Hoff MH

Aggressive Mammary Cancers Lacking Lymphocytic Infiltration Arise in Irradiated Mice and Can be Prevented by Dietary Intervention.

Cancer immunology research

Omene C, Ma L, Moore J, Ouyang H, Illa-Bochaca I, Chou W, Patel MS, Sebastiano C, Demaria S, Mao JH, Karagoz K, Gatza ML, Barcellos-Hoff MH

Misrepair in Context: TGFß Regulation of DNA Repair.

Frontiers in oncology

Liu Q, Lopez K, Murnane J, Humphrey T, Barcellos-Hoff MH

Enhancing Career Paths for Tomorrow's Radiation Oncologists.

International journal of radiation oncology, biology, physics

Vapiwala N, Thomas CR, Grover S, Yap ML, Mitin T, Shulman LN, Gospodarowicz MK, Longo J, Petereit DG, Ennis RD, Hayman JA, Rodin D, Buchsbaum JC, Vikram B, Abdel-Wahab M, Epstein AH, Okunieff P, Goldwein J, Kupelian P, Weidhaas JB, Tucker MA, Boice JD, Fuller CD, Thompson RF, Trister AD, Formenti SC, Barcellos-Hoff MH, Jones J, Dharmarajan KV, Zietman AL, Coleman CN

Autocrine TGFß is a Survival Factor for Monocytes and Drives Immunosuppressive Lineage Commitment.

Cancer immunology research

Gonzalez-Junca A, Driscoll K, Pellicciotta I, Du S, Lo CH, Roy R, Parry R, Tenvooren I, Marquez D, Spitzer MH, Barcellos-Hoff MH

Subjugation of TGFß Signaling by Human Papilloma Virus in Head and Neck Squamous Cell Carcinoma Shifts DNA Repair from Homologous Recombination to Alternative End Joining.

Clinical cancer research : an official journal of the American Association for Cancer Research

Liu Q, Ma L, Jones T, Palomero L, Pujana MA, Martinez-Ruiz H, Ha PK, Murnane J, Cuartas I, Seoane J, Baumann M, Linge A, Barcellos-Hoff MH

Evaluation of Radioresponse and Radiosensitizers in Glioblastoma Organotypic Cultures.

Methods in molecular biology (Clifton, N.J.)

Bayin NS, Ma L, Placantonakis DG, Barcellos-Hoff MH

Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells.

Oncotarget

Bayin NS, Frenster JD, Sen R, Si S, Modrek AS, Galifianakis N, Dolgalev I, Ortenzi V, Illa-Bochaca I, Khahera A, Serrano J, Chiriboga L, Zagzag D, Golfinos JG, Doyle W, Tsirigos A, Heguy A, Chesler M, Barcellos-Hoff MH, Snuderl M, Placantonakis DG

Radiation-Induced Fibrosis: Mechanisms and Opportunities to Mitigate. Report of an NCI Workshop, September 19, 2016.

Radiation research

Citrin DE, Prasanna PGS, Walker AJ, Freeman ML, Eke I, Barcellos-Hoff MH, Arankalayil MJ, Cohen EP, Wilkins RC, Ahmed MM, Anscher MS, Movsas B, Buchsbaum JC, Mendonca MS, Wynn TA, Coleman CN

Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition.

Oncogene

Mateo F, Arenas EJ, Aguilar H, Serra-Musach J, de Garibay GR, Boni J, Maicas M, Du S, Iorio F, Herranz-Ors C, Islam A, Prado X, Llorente A, Petit A, Vidal A, Català I, Soler T, Venturas G, Rojo-Sebastian A, Serra H, Cuadras D, Blanco I, Lozano J, Canals F, Sieuwerts AM, de Weerd V, Look MP, Puertas S, García N, Perkins AS, Bonifaci N, Skowron M, Gómez-Baldó L, Hernández V, Martínez-Aranda A, Martínez-Iniesta M, Serrat X, Cerón J, Brunet J, Barretina MP, Gil M, Falo C, Fernández A, Morilla I, Pernas S, Plà MJ, Andreu X, Seguí MA, Ballester R, Castellà E, Nellist M, Morales S, Valls J, Velasco A, Matias-Guiu X, Figueras A, Sánchez-Mut JV, Sánchez-Céspedes M, Cordero A, Gómez-Miragaya J, Palomero L, Gómez A, Gajewski TF, Cohen EEW, Jesiotr M, Bodnar L, Quintela-Fandino M, López-Bigas N, Valdés-Mas R, Puente XS, Viñals F, Casanovas O, Graupera M, Hernández-Losa J, Ramón Y Cajal S, García-Alonso L, Saez-Rodriguez J, Esteller M, Sierra A, Martín-Martín N, Matheu A, Carracedo A, González-Suárez E, Nanjundan M, Cortés J, Lázaro C, Odero MD, Martens JWM, Moreno-Bueno G, Barcellos-Hoff MH, Villanueva A, Gomis RR, Pujana MA

A TGFß-miR-182-BRCA1 axis controls the mammary differentiation hierarchy.

Science signaling

Martinez-Ruiz H, Illa-Bochaca I, Omene C, Hanniford D, Liu Q, Hernando E, Barcellos-Hoff MH

Patient-Specific Screening Using High-Grade Glioma Explants to Determine Potential Radiosensitization by a TGF-ß Small Molecule Inhibitor.

Neoplasia (New York, N.Y.)

Bayin NS, Ma L, Thomas C, Baitalmal R, Sure A, Fansiwala K, Bustoros M, Golfinos JG, Pacione D, Snuderl M, Zagzag D, Barcellos-Hoff MH, Placantonakis D

Subverting misconceptions about radiation therapy.

Nature immunology

Formenti SC, Demaria S, Barcellos-Hoff MH, McBride WH

ICRP Publication 131: Stem cell biology with respect to carcinogenesis aspects of radiological protection.

Annals of the ICRP

Hendry JH, Niwa O, Barcellos-Hoff MH, Globus RK, Harrison JD, Martin MT, Seed TM, Shay JW, Story MD, Suzuki K, Yamashita S

The Microenvironment of Lung Cancer and Therapeutic Implications.

Advances in experimental medicine and biology

Mittal V, El Rayes T, Narula N, McGraw TE, Altorki NK, Barcellos-Hoff MH

"Praising What Is Lost. . .

Radiation research

Barcellos-Hoff MH, Iliakis G, Jeggo P, McKenna G, O'Neil P, Wallace S

ICRP Publication 131: Stem Cell Biology with Respect to Carcinogenesis Aspects of Radiological Protection.

Annals of the ICRP

Niwa O, Barcellos-Hoff MH, Globus RK, Harrison JD, Hendry JH, Jacob P, Martin MT, Seed TM, Shay JW, Story MD, Suzuki K, Yamashita S

Whither ICRR?

Radiation research

Brown M, Held K, Mason K, McBride B, Willey J, Williams J

Concepts and challenges in cancer risk prediction for the space radiation environment.

Life sciences in space research

Barcellos-Hoff MH, Blakely EA, Burma S, Fornace AJ, Gerson S, Hlatky L, Kirsch DG, Luderer U, Shay J, Wang Y, Weil MM

The effect of environmental chemicals on the tumor microenvironment.

Carcinogenesis

Casey SC, Vaccari M, Al-Mulla F, Al-Temaimi R, Amedei A, Barcellos-Hoff MH, Brown DG, Chapellier M, Christopher J, Curran CS, Forte S, Hamid RA, Heneberg P, Koch DC, Krishnakumar PK, Laconi E, Maguer-Satta V, Marongiu F, Memeo L, Mondello C, Raju J, Roman J, Roy R, Ryan EP, Ryeom S, Salem HK, Scovassi AI, Singh N, Soucek L, Vermeulen L, Whitfield JR, Woodrick J, Colacci A, Bisson WH, Felsher DW

TGFß Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity.

Cancer research

Vanpouille-Box C, Diamond JM, Pilones KA, Zavadil J, Babb JS, Formenti SC, Barcellos-Hoff MH, Demaria S

Identification of genetic loci that control mammary tumor susceptibility through the host microenvironment.

Scientific reports

Zhang P, Lo A, Huang Y, Huang G, Liang G, Mott J, Karpen GH, Blakely EA, Bissell MJ, Barcellos-Hoff MH, Snijders AM, Mao JH

BUB1-bling over with possibilities.

Neoplasia (New York, N.Y.)

Barcellos-Hoff MH

Age- and pregnancy-associated DNA methylation changes in mammary epithelial cells.

Stem cell reports

Huh SJ, Clement K, Jee D, Merlini A, Choudhury S, Maruyama R, Yoo R, Chytil A, Boyle P, Ran FA, Moses HL, Barcellos-Hoff MH, Jackson-Grusby L, Meissner A, Polyak K

Development of a novel multiplexed assay for quantification of transforming growth factor-ß (TGF-ß).

Growth factors (Chur, Switzerland)

Pellicciotta I, Marciscano AE, Hardee ME, Francis D, Formenti S, Barcellos-Hoff MH

Attenuation of the DNA damage response by transforming growth factor-beta inhibitors enhances radiation sensitivity of non-small-cell lung cancer cells in vitro and in vivo.

International journal of radiation oncology, biology, physics

Du S, Bouquet S, Lo CH, Pellicciotta I, Bolourchi S, Parry R, Barcellos-Hoff MH

TGFß1 protects cells from ?-IR by enhancing the activity of the NHEJ repair pathway.

Molecular cancer research : MCR

Kim MR, Lee J, An YS, Jin YB, Park IC, Chung E, Shin I, Barcellos-Hoff MH, Yi JY

Densely ionizing radiation acts via the microenvironment to promote aggressive Trp53-null mammary carcinomas.

Cancer research

Illa-Bochaca I, Ouyang H, Tang J, Sebastiano C, Mao JH, Costes SV, Demaria S, Barcellos-Hoff MH

Soil amendments that slow cancer growth.

Cancer discovery

Isacke CM, Barcellos-Hoff MH

Photoactivation of endogenous latent transforming growth factor-ß1 directs dental stem cell differentiation for regeneration.

Science translational medicine

Arany PR, Cho A, Hunt TD, Sidhu G, Shin K, Hahm E, Huang GX, Weaver J, Chen AC, Padwa BL, Hamblin MR, Barcellos-Hoff MH, Kulkarni AB, J Mooney D

Irradiation of juvenile, but not adult, mammary gland increases stem cell self-renewal and estrogen receptor negative tumors.

Stem cells (Dayton, Ohio)

Tang J, Fernandez-Garcia I, Vijayakumar S, Martinez-Ruis H, Illa-Bochaca I, Nguyen DH, Mao JH, Costes SV, Barcellos-Hoff MH

Noninvasive diagnosis and management of spontaneous intracranial hypotension in patients with marfan syndrome: Case Report and Review of the Literature.

Surgical neurology international

Bassani L, Graffeo CS, Behrooz N, Tyagi V, Wilson T, Penaranda S, Zagzag D, Rifkin DB, Barcellos-Hoff MH, Fatterpekar G, Placantonakis D

Breast cancer risk in BRCA1 mutation carriers: insight from mouse models.

Annals of oncology : official journal of the European Society for Medical Oncology

Barcellos-Hoff MH, Kleinberg DL

The evolution of the cancer niche during multistage carcinogenesis.

Nature reviews. Cancer

Barcellos-Hoff MH, Lyden D, Wang TC

Murine microenvironment metaprofiles associate with human cancer etiology and intrinsic subtypes.

Clinical cancer research : an official journal of the American Association for Cancer Research

Nguyen DH, Fredlund E, Zhao W, Perou CM, Balmain A, Mao JH, Barcellos-Hoff MH

New biological insights on the link between radiation exposure and breast cancer risk.

Journal of mammary gland biology and neoplasia

Barcellos-Hoff MH

Does microenvironment contribute to the etiology of estrogen receptor-negative breast cancer?

Clinical cancer research : an official journal of the American Association for Cancer Research

Barcellos-Hoff MH

The convergence of radiation and immunogenic cell death signaling pathways.

Frontiers in oncology

Golden EB, Pellicciotta I, Demaria S, Barcellos-Hoff MH, Formenti SC

Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-ß.

Cancer research

Hardee ME, Marciscano AE, Medina-Ramirez CM, Zagzag D, Narayana A, Lonning SM, Barcellos-Hoff MH

Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer.

PLoS biology

Maxwell CA, Benítez J, Gómez-Baldó L, Osorio A, Bonifaci N, Fernández-Ramires R, Costes SV, Guinó E, Chen H, Evans GJ, Mohan P, Català I, Petit A, Aguilar H, Villanueva A, Aytes A, Serra-Musach J, Rennert G, Lejbkowicz F, Peterlongo P, Manoukian S, Peissel B, Ripamonti CB, Bonanni B, Viel A, Allavena A, Bernard L, Radice P, Friedman E, Kaufman B, Laitman Y, Dubrovsky M, Milgrom R, Jakubowska A, Cybulski C, Gorski B, Jaworska K, Durda K, Sukiennicki G, Lubinski J, Shugart YY, Domchek SM, Letrero R, Weber BL, Hogervorst FB, Rookus MA, Collee JM, Devilee P, Ligtenberg MJ, Luijt RB, Aalfs CM, Waisfisz Q, Wijnen J, Roozendaal CE, Easton DF, Peock S, Cook M, Oliver C, Frost D, Harrington P, Evans DG, Lalloo F, Eeles R, Izatt L, Chu C, Eccles D, Douglas F, Brewer C, Nevanlinna H, Heikkinen T, Couch FJ, Lindor NM, Wang X, Godwin AK, Caligo MA, Lombardi G, Loman N, Karlsson P, Ehrencrona H, Wachenfeldt Av, Barkardottir RB, Hamann U, Rashid MU, Lasa A, Caldés T, Andrés R, Schmitt M, Assmann V, Stevens K, Offit K, Curado J, Tilgner H, Guigó R, Aiza G, Brunet J, Castellsagué J, Martrat G, Urruticoechea A, Blanco I, Tihomirova L, Goldgar DE, Buys S, John EM, Miron A, Southey M, Daly MB, Schmutzler RK, Wappenschmidt B, Meindl A, Arnold N, Deissler H, Varon-Mateeva R, Sutter C, Niederacher D, Imyamitov E, Sinilnikova OM, Stoppa-Lyonne D, Mazoyer S, Verny-Pierre C, Castera L, de Pauw A, Bignon YJ, Uhrhammer N, Peyrat JP, Vennin P, Fert Ferrer S, Collonge-Rame MA, Mortemousque I, Spurdle AB, Beesley J, Chen X, Healey S, Barcellos-Hoff MH, Vidal M, Gruber SB, Lázaro C, Capellá G, McGuffog L, Nathanson KL, Antoniou AC, Chenevix-Trench G, Fleisch MC, Moreno V, Pujana MA

TGFß1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo.

Clinical cancer research : an official journal of the American Association for Cancer Research

Bouquet F, Pal A, Pilones KA, Demaria S, Hann B, Akhurst RJ, Babb JS, Lonning SM, DeWyngaert JK, Formenti SC, Barcellos-Hoff MH

The pivotal role of insulin-like growth factor I in normal mammary development.

Endocrinology and metabolism clinics of North America

Kleinberg DL, Barcellos-Hoff MH

TGFß biology in breast: 15 years on.

Journal of mammary gland biology and neoplasia

Barcellos-Hoff MH

Consequences of epithelial or stromal TGFß1 depletion in the mammary gland.

Journal of mammary gland biology and neoplasia

Nguyen DH, Martinez-Ruiz H, Barcellos-Hoff MH

Radiation acts on the microenvironment to affect breast carcinogenesis by distinct mechanisms that decrease cancer latency and affect tumor type.

Cancer cell

Nguyen DH, Oketch-Rabah HA, Illa-Bochaca I, Geyer FC, Reis-Filho JS, Mao JH, Ravani SA, Zavadil J, Borowsky AD, Jerry DJ, Dunphy KA, Seo JH, Haslam S, Medina D, Barcellos-Hoff MH

Low-dose radiation knowledge worth the cost.

Science (New York, N.Y.)

Barcellos-Hoff MH, Brenner DJ, Brooks AL, Formenti S, Hlatky L, Locke PA, Shore R, Tenforde T, Travis EL, Williams J

Lack of radiation dose or quality dependence of epithelial-to-mesenchymal transition (EMT) mediated by transforming growth factor ß.

International journal of radiation oncology, biology, physics

Andarawewa KL, Costes SV, Fernandez-Garcia I, Chou WS, Ravani SA, Park H, Barcellos-Hoff MH

In honor of Mina J. Bissell.

Integrative biology : quantitative biosciences from nano to macro

Barcellos-Hoff MH

TGF-beta biology in mammary development and breast cancer.

Cold Spring Harbor perspectives in biology

Moses H, Barcellos-Hoff MH

Stromal mediation of radiation carcinogenesis.

Journal of mammary gland biology and neoplasia

Barcellos-Hoff MH

Multiscale iterative voting for differential analysis of stress response for 2D and 3D cell culture models.

Journal of microscopy

Han J, Chang H, Yang Q, Fontenay G, Groesser T, Barcellos-Hoff MH, Parvin B

Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studies.

Breast cancer research : BCR

Mukhopadhyay R, Costes SV, Bazarov AV, Hines WC, Barcellos-Hoff MH, Yaswen P

In situ analysis of cell populations: long-term label-retaining cells.

Methods in molecular biology (Clifton, N.J.)

Fernandez-Gonzalez R, Illa-Bochaca I, Shelton DN, Welm BE, Barcellos-Hoff MH, Ortiz-de-Solorzano C

Limiting-dilution transplantation assays in mammary stem cell studies.

Methods in molecular biology (Clifton, N.J.)

Illa-Bochaca I, Fernandez-Gonzalez R, Shelton DN, Welm BE, Ortiz-de-Solorzano C, Barcellos-Hoff MH

Multidimensional profiling of cell surface proteins and nuclear markers.

IEEE/ACM transactions on computational biology and bioinformatics

Han J, Chang H, Andarawewa K, Yaswen P, Barcellos-Hoff MH, Parvin B

Use of stem cell markers in dissociated mammary populations.

Methods in molecular biology (Clifton, N.J.)

Shelton DN, Fernandez-Gonzalez R, Illa-Bochaca I, Ortiz-de-Solorzano C, Barcellos-Hoff MH, Welm BE

Resistance to radio- and chemotherapy and the tumour microenvironment.

International journal of radiation biology

Barcellos-Hoff MH, Cordes N

Therapeutic targets in malignant glioblastoma microenvironment.

Seminars in radiation oncology

Barcellos-Hoff MH, Newcomb EW, Zagzag D, Narayana A

Transforming growth factor-beta in breast cancer: too much, too late.

Breast cancer research : BCR

Barcellos-Hoff MH, Akhurst RJ

Integrating biology and technology.

Integrative biology : quantitative biosciences from nano to macro

Barcellos-Hoff MH, Beebe D

Mapping mammary gland architecture using multi-scale in situ analysis.

Integrative biology : quantitative biosciences from nano to macro

Fernandez-Gonzalez R, Illa-Bochaca I, Welm BE, Fleisch MC, Werb Z, Ortiz-de-Solorzano C, Barcellos-Hoff MH

Targeted and nontargeted effects of ionizing radiation that impact genomic instability.

Cancer research

Maxwell CA, Fleisch MC, Costes SV, Erickson AC, Boissière A, Gupta R, Ravani SA, Parvin B, Barcellos-Hoff MH

Cancer as an emergent phenomenon in systems radiation biology.

Radiation and environmental biophysics

Barcellos-Hoff MH

New rationales for using TGFbeta inhibitors in radiotherapy.

International journal of radiation biology

Andarawewa KL, Paupert J, Pal A, Barcellos-Hoff MH

Radiation therapy and the microenvironment.

International journal of radiation biology

Barcellos-Hoff MH, Cordes N

Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition.

Cancer research

Andarawewa KL, Erickson AC, Chou WS, Costes SV, Gascard P, Mott JD, Bissell MJ, Barcellos-Hoff MH

Image-based modeling reveals dynamic redistribution of DNA damage into nuclear sub-domains.

PLoS computational biology

Costes SV, Ponomarev A, Chen JL, Nguyen D, Cucinotta FA, Barcellos-Hoff MH

The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression.

Molecular oncology

Kenny PA, Lee GY, Myers CA, Neve RM, Semeiks JR, Spellman PT, Lorenz K, Lee EH, Barcellos-Hoff MH, Petersen OW, Gray JW, Bissell MJ

Iterative voting for inference of structural saliency and characterization of subcellular events.

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

Parvin B, Yang Q, Han J, Chang H, Rydberg B, Barcellos-Hoff MH

Geometric approach to segmentation and protein localization in cell culture assays.

Journal of microscopy

Raman S, Maxwell CA, Barcellos-Hoff MH, Parvin B

Intensity-based signal separation algorithm for accurate quantification of clustered centrosomes in tissue sections.

Microscopy research and technique

Fleisch MC, Maxwell CA, Kuper CK, Brown ET, Barcellos-Hoff MH, Costes SV

Isoform-specific activation of latent transforming growth factor beta (LTGF-beta) by reactive oxygen species.

Radiation research

Jobling MF, Mott JD, Finnegan MT, Jurukovski V, Erickson AC, Walian PJ, Taylor SE, Ledbetter S, Lawrence CM, Rifkin DB, Barcellos-Hoff MH

Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress.

Cancer research

Kirshner J, Jobling MF, Pajares MJ, Ravani SA, Glick AB, Lavin MJ, Koslov S, Shiloh Y, Barcellos-Hoff MH

Quantitative in vivo microscopy: the return from the 'omics'.

Current opinion in biotechnology

Fernández-González R, Muñoz-Barrutia A, Barcellos-Hoff MH, Ortiz-de-Solorzano C

Imaging features that discriminate between foci induced by high- and low-LET radiation in human fibroblasts.

Radiation research

Costes SV, Boissière A, Ravani S, Romano R, Parvin B, Barcellos-Hoff MH

Radiation and the microenvironment - tumorigenesis and therapy.

Nature reviews. Cancer

Barcellos-Hoff MH, Park C, Wright EG

Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression.

Oncogene

Muraoka-Cook RS, Shin I, Yi JY, Easterly E, Barcellos-Hoff MH, Yingling JM, Zent R, Arteaga CL

A tool for the quantitative spatial analysis of complex cellular systems.

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

Fernandez-Gonzalez R, Barcellos-Hoff MH, Ortiz-de-Solórzano C

Proliferation of estrogen receptor-alpha-positive mammary epithelial cells is restrained by transforming growth factor-beta1 in adult mice.

The American journal of pathology

Ewan KB, Oketch-Rabah HA, Ravani SA, Shyamala G, Moses HL, Barcellos-Hoff MH

Conditional overexpression of active transforming growth factor beta1 in vivo accelerates metastases of transgenic mammary tumors.

Cancer research

Muraoka-Cook RS, Kurokawa H, Koh Y, Forbes JT, Roebuck LR, Barcellos-Hoff MH, Moody SE, Chodosh LA, Arteaga CL

Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003.

Radiation research

Stone HB, Moulder JE, Coleman CN, Ang KK, Anscher MS, Barcellos-Hoff MH, Dynan WS, Fike JR, Grdina DJ, Greenberger JS, Hauer-Jensen M, Hill RP, Kolesnick RN, Macvittie TJ, Marks C, McBride WH, Metting N, Pellmar T, Purucker M, Robbins ME, Schiestl RH, Seed TM, Tomaszewski JE, Travis EL, Wallner PE, Wolpert M, Zaharevitz D

New highlights on stroma-epithelial interactions in breast cancer.

Breast cancer research : BCR

Barcellos-Hoff MH, Medina D

Quantitative image analysis in mammary gland biology.

Journal of mammary gland biology and neoplasia

Fernandez-Gonzalez R, Barcellos-Hoff MH, Ortiz-de-Solórzano C

Education and training for radiation scientists: radiation research program and American Society of Therapeutic Radiology and Oncology Workshop, Bethesda, Maryland, May 12-14, 2003.

Radiation research

Coleman CN, Stone HB, Alexander GA, Barcellos-Hoff MH, Bedford JS, Bristow RG, Dynlacht JR, Fuks Z, Gorelic LS, Hill RP, Joiner MC, Liu FF, McBride WH, McKenna WG, Powell SN, Robbins ME, Rockwell S, Schiff PB, Shaw EG, Siemann DW, Travis EL, Wallner PE, Wong RS, Zeman EM

Ionizing radiation induces heritable disruption of epithelial cell interactions.

Proceedings of the National Academy of Sciences of the United States of America

Park CC, Henshall-Powell RL, Erickson AC, Talhouk R, Parvin B, Bissell MJ, Barcellos-Hoff MH

The not-so innocent bystander: the microenvironment as a therapeutic target in cancer.

Expert opinion on therapeutic targets

Erickson AC, Barcellos-Hoff MH

BioSig: an imaging bioinformatics system for phenotypic analysis.

IEEE transactions on systems, man, and cybernetics. Part B, Cybernetics : a publication of the IEEE Systems, Man, and Cybernetics Society

Parvin B, Yang Q, Fontenay G, Barcellos-Hoff MH

System for combined three-dimensional morphological and molecular analysis of thick tissue specimens.

Microscopy research and technique

Fernandez-Gonzalez R, Jones A, Garcia-Rodriguez E, Chen PY, Idica A, Lockett SJ, Barcellos-Hoff MH, Ortiz-De-Solorzano C

Applications of quantitative digital image analysis to breast cancer research.

Microscopy research and technique

Ortiz De Solórzano C, Costes S, Callahan DE, Parvin B, Barcellos-Hoff MH

Transforming growth factor-beta1 mediates cellular response to DNA damage in situ.

Cancer research

Ewan KB, Henshall-Powell RL, Ravani SA, Pajares MJ, Arteaga C, Warters R, Akhurst RJ, Barcellos-Hoff MH

Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts.

Journal of the National Cancer Institute

Wang F, Hansen RK, Radisky D, Yoneda T, Barcellos-Hoff MH, Petersen OW, Turley EA, Bissell MJ

Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferation.

The American journal of pathology

Ewan KB, Shyamala G, Ravani SA, Tang Y, Akhurst R, Wakefield L, Barcellos-Hoff MH

Radiation quality and tissue-specific microenvironments following exposure to 1 GeV/amu Fe.

Advances in space research : the official journal of the Committee on Space Research (COSPAR)

Costes S, Barcellos-Hoff MH

Immunodetection of 3-nitrotyrosine in the liver of zymosan-treated rats with a new monoclonal antibody: comparison to analysis by HPLC.

Free radical biology & medicine

Girault I, Karu AE, Schaper M, Barcellos-Hoff MH, Hagen T, Vogel DS, Ames BN, Christen S, Shigenaga MK

Epigenetics and breast cancer.

Journal of mammary gland biology and neoplasia

Asch BB, Barcellos-Hoff MH

It takes a tissue to make a tumor: epigenetics, cancer and the microenvironment.

Journal of mammary gland biology and neoplasia

Barcellos-Hoff MH

Loss of heterozygosity at the mannose 6-phosphate insulin-like growth factor 2 receptor (M6P/IGF2R) locus predisposes patients to radiation-induced lung injury.

International journal of radiation oncology, biology, physics

Kong FM, Anscher MS, Sporn TA, Washington MK, Clough R, Barcellos-Hoff MH, Jirtle RL

Particle irradiation induces FGF2 expression in normal human lens cells.

Radiation research

Chang PY, Bjornstad K A, Chang E, McNamara M, Barcellos-Hoff MH, Lin SP, Aragon G, Polansky JR, Lui GM, Blakely EA

The influence of the microenvironment on the malignant phenotype.

Molecular medicine today

Park CC, Bissell MJ, Barcellos-Hoff MH

Transforming growth factor-beta and breast cancer: Mammary gland development.

Breast cancer research : BCR

Barcellos-Hoff MH, Ewan KB

Modulation of protein expression and activity by radiation: relevance to intracoronary radiation for the prevention of restenosis.

Cardiovascular radiation medicine

Vodovotz Y, Mitchell JB, Lucia MS, McKinney L, Kollum M, Cottin Y, Chan RC, Barcellos-Hoff MH, Waksman R

Ionizing radiation accelerates aortic lesion formation in fat-fed mice via SOD-inhibitable processes.

Arteriosclerosis, thrombosis, and vascular biology

Tribble DL, Barcellos-Hoff MH, Chu BM, Gong EL

Regulation of transforming growth factor beta1 by nitric oxide.

Cancer research

Vodovotz Y, Chesler L, Chong H, Kim SJ, Simpson JT, DeGraff W, Cox GW, Roberts AB, Wink DA, Barcellos-Hoff MH

Immunocytochemical localization of latent transforming growth factor-beta1 activation by stimulated macrophages.

Journal of cellular physiology

Chong H, Vodovotz Y, Cox GW, Barcellos-Hoff MH

The potential influence of radiation-induced microenvironments in neoplastic progression.

Journal of mammary gland biology and neoplasia

Barcellos-Hoff MH

Transgenic mice carrying an imbalance in the native ratio of A to B forms of progesterone receptor exhibit developmental abnormalities in mammary glands.

Proceedings of the National Academy of Sciences of the United States of America

Shyamala G, Yang X, Silberstein G, Barcellos-Hoff MH, Dale E

Latent transforming growth factor beta1 activation in situ: quantitative and functional evidence after low-dose gamma-irradiation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Ehrhart EJ, Segarini P, Tsang ML, Carroll AG, Barcellos-Hoff MH

Transforming growth factor-beta in breast cancer: a working hypothesis.

Breast cancer research and treatment

Reiss M, Barcellos-Hoff MH

Latency and activation in the control of TGF-beta.

Journal of mammary gland biology and neoplasia

Barcellos-Hoff MH

Redox-mediated activation of latent transforming growth factor-beta 1.

Molecular endocrinology (Baltimore, Md.)

Barcellos-Hoff MH, Dix TA

Immunohistochemical detection of active transforming growth factor-beta in situ using engineered tissue.

The American journal of pathology

Barcellos-Hoff MH, Ehrhart EJ, Kalia M, Jirtle R, Flanders K, Tsang ML

Transforming growth factor-beta activation in irradiated murine mammary gland.

The Journal of clinical investigation

Barcellos-Hoff MH, Derynck R, Tsang ML, Weatherbee JA

Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane.

Development (Cambridge, England)

Barcellos-Hoff MH, Aggeler J, Ram TG, Bissell MJ

Measurement of sister chromatid exchanges and their relationship to DNA damage, repair and cell killing.

Pharmacology & therapeutics

Deen DF, Morgan WF, Tofilon PJ, Barcellos-Hoff MH

Cell-cycle, phase-specific cell killing by carmustine in sensitive and resistant cells.

NCI monographs : a publication of the National Cancer Institute

Linfoot PA, Barcellos-Hoff MH, Brent TP, Marton LJ, Deen DF

Transferrin is a major mouse milk protein and is synthesized by mammary epithelial cells.

In vitro cellular & developmental biology : journal of the Tissue Culture Association

Lee EY, Barcellos-Hoff MH, Chen LH, Parry G, Bissell MJ

The influence of extracellular matrix on gene expression: is structure the message?

Journal of cell science. Supplement

Bissell MJ, Barcellos-Hoff MH

Growth delay in 9L rat brain tumor spheroids after irradiation with single and split doses of X rays.

Radiation research

Jostes RF, Williams ME, Barcellos-Hoff MH, Hoshino T, Deen DF

The effect of combination treatment with cis-platinum and low dose rate 125I radiation in a murine brachytherapy model.

International journal of radiation oncology, biology, physics

da Silva V, Gutin PH, Barcellos-Hoff MH, Bernstein MA, Deen DF, Weaver KA