Thea Tlsty, PhD

+1 415 502-6116

Dr. Tlsty has over 25 years of experience in studying human cells and the earliest responses to injury. She has lead multi-disciplinary groups that address both the epithelial and stromal contributions to wound healing and malignancy. The model systems the Tlsty laboratory has developed and the applied translational insights obtained have great potential to contribute to clinical utility.

Our work was the first to develop biomarkers for risk stratification of ductal carcinoma in situ, a pre-malignant lesion of breast cancer. Our recent work has identified molecular aspects of stromal-epithelial stress responses and the interactions that facilitate tumor progression in breast, prostate and other cancers. These analyses have enabled us to identify cell-extrinsic consequences of epithelial stress that lead to the activation of pro-tumorigenic stromal phenotypes. One of the most profound phenotypes involves the activation of a multicellular stromal program shared by high mammographic density and desmoplastic tumor tissues, characterized by repression of CD36. While studying these interactions we unexpectedly found a rare population of cells within disease-free tissue that has the potential to attain pluripotency. These cells have the ability to create functional tissues of all three germ layers which we hypothesize may be involved in metaplasia and inflammatory diseases. A single pluripotent cell can generate beating cardiomyocytes, lactating breast, bone, cartilage, vasculature, adipocytes, pancreas, and intestinal cells. We hypothesize that these cells may be the cell-of-origin for metaplastic cancers and provide insights for the identification of novel therapeutic targets. Similarly, these cells may be responsible for a wide collection of phenotypes that are initiated by chronic stress and defective in a wide spectrum of cancers. Our current studies, couched in a large multi-disciplinary, multi-investigator grant, are aimed at investigating the role of chronic inflammation in increased cancer incidence with the intent of developing preventive and therapeutic solutions.


Mapping hormone-regulated cell-cell interaction networks in the human breast at single-cell resolution.

Cell systems

Murrow LM, Weber RJ, Caruso JA, McGinnis CS, Phong K, Gascard P, Rabadam G, Borowsky AD, Desai TA, Thomson M, Tlsty T, Gartner ZJ

A framework for advancing our understanding of cancer-associated fibroblasts.

Nature reviews. Cancer

Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, Hynes RO, Jain RK, Janowitz T, Jorgensen C, Kimmelman AC, Kolonin MG, Maki RG, Powers RS, Puré E, Ramirez DC, Scherz-Shouval R, Sherman MH, Stewart S, Tlsty TD, Tuveson DA, Watt FM, Weaver V, Weeraratna AT, Werb Z

Stromal directives can control cancer.

Science (New York, N.Y.)

Tlsty TD, Gascard P

Introducing cancer convergence.

Cancer convergence

Blagoev KB, Ting DT, Levine H, Saenger Y, Tlsty TD, Sun B

Metastatic State of Cancer Cells May Be Indicated by Adhesion Strength.

Biophysical journal

Fuhrmann A, Banisadr A, Beri P, Tlsty TD, Engler AJ

SOX2, OCT3/4 and NANOG expression and cellular plasticity in rare human somatic cells requires CD73.

Cellular signalling

Pan D, Roy S, Gascard P, Zhao J, Chen-Tanyolac C, Tlsty TD

Risk prediction for local versus regional/metastatic tumors after initial ductal carcinoma in situ diagnosis treated by lumpectomy.

Breast cancer research and treatment

Molinaro AM, Sison JD, Ljung BM, Tlsty TD, Kerlikowske K

Novel insights from 3D models: the pivotal role of physical symmetry in epithelial organization.

Scientific reports

Kurup A, Ravindranath S, Tran T, Keating M, Gascard P, Valdevit L, Tlsty TD, Botvinick EL

Towards aspirin-inspired self-immolating molecules which target the cyclooxygenases.

Organic & biomolecular chemistry

Drake CR, Estévez-Salmerón L, Gascard P, Shen Y, Tlsty TD, Jones EF

Integrative analysis of 111 reference human epigenomes.


Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon G, Sandstrom RS, Eaton ML, Wu YC, Pfenning AR, Wang X, Claussnitzer M, Liu Y, Coarfa C, Harris RA, Shoresh N, Epstein CB, Gjoneska E, Leung D, Xie W, Hawkins RD, Lister R, Hong C, Gascard P, Mungall AJ, Moore R, Chuah E, Tam A, Canfield TK, Hansen RS, Kaul R, Sabo PJ, Bansal MS, Carles A, Dixon JR, Farh KH, Feizi S, Karlic R, Kim AR, Kulkarni A, Li D, Lowdon R, Elliott G, Mercer TR, Neph SJ, Onuchic V, Polak P, Rajagopal N, Ray P, Sallari RC, Siebenthall KT, Sinnott-Armstrong NA, Stevens M, Thurman RE, Wu J, Zhang B, Zhou X, Beaudet AE, Boyer LA, De Jager PL, Farnham PJ, Fisher SJ, Haussler D, Jones SJ, Li W, Marra MA, McManus MT, Sunyaev S, Thomson JA, Tlsty TD, Tsai LH, Wang W, Waterland RA, Zhang MQ, Chadwick LH, Bernstein BE, Costello JF, Ecker JR, Hirst M, Meissner A, Milosavljevic A, Ren B, Stamatoyannopoulos JA, Wang T, Kellis M

Epigenetic and transcriptional determinants of the human breast.

Nature communications

Gascard P, Bilenky M, Sigaroudinia M, Zhao J, Li L, Carles A, Delaney A, Tam A, Kamoh B, Cho S, Griffith M, Chu A, Robertson G, Cheung D, Li I, Heravi-Moussavi A, Moksa M, Mingay M, Hussainkhel A, Davis B, Nagarajan RP, Hong C, Echipare L, O'Geen H, Hangauer MJ, Cheng JB, Neel D, Hu D, McManus MT, Moore R, Mungall A, Ma Y, Plettner P, Ziv E, Wang T, Farnham PJ, Jones SJ, Marra MA, Tlsty TD, Costello JF, Hirst M

Intermediate DNA methylation is a conserved signature of genome regulation.

Nature communications

Elliott G, Hong C, Xing X, Zhou X, Li D, Coarfa C, Bell RJ, Maire CL, Ligon KL, Sigaroudinia M, Gascard P, Tlsty TD, Harris RA, Schalkwyk LC, Bilenky M, Mill J, Farnham PJ, Kellis M, Marra MA, Milosavljevic A, Hirst M, Stormo GD, Wang T, Costello JF

Regulatory network decoded from epigenomes of surface ectoderm-derived cell types.

Nature communications

Lowdon RF, Zhang B, Bilenky M, Mauro T, Li D, Gascard P, Sigaroudinia M, Farnham PJ, Bastian BC, Tlsty TD, Marra MA, Hirst M, Costello JF, Wang T, Cheng JB

Stress signaling from human mammary epithelial cells contributes to phenotypes of mammographic density.

Cancer research

DeFilippis RA, Fordyce C, Patten K, Chang H, Zhao J, Fontenay GV, Kerlikowske K, Parvin B, Tlsty TD

Cell motility and drug gradients in the emergence of resistance to chemotherapy.

Proceedings of the National Academy of Sciences of the United States of America

Wu A, Loutherback K, Lambert G, Estévez-Salmerón L, Tlsty TD, Austin RH, Sturm JC

Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm.

Genome research

Zhang B, Zhou Y, Lin N, Lowdon RF, Hong C, Nagarajan RP, Cheng JB, Li D, Stevens M, Lee HJ, Xing X, Zhou J, Sundaram V, Elliott G, Gu J, Shi T, Gascard P, Sigaroudinia M, Tlsty TD, Kadlecek T, Weiss A, O'Geen H, Farnham PJ, Maire CL, Ligon KL, Madden PA, Tam A, Moore R, Hirst M, Marra MA, Zhang B, Costello JF, Wang T

DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape.

Nature genetics

Xie M, Hong C, Zhang B, Lowdon RF, Xing X, Li D, Zhou X, Lee HJ, Maire CL, Ligon KL, Gascard P, Sigaroudinia M, Tlsty TD, Kadlecek T, Weiss A, O'Geen H, Farnham PJ, Madden PA, Mungall AJ, Tam A, Kamoh B, Cho S, Moore R, Hirst M, Marra MA, Costello JF, Wang T

Coordinate transcriptional and translational repression of p53 by TGF-ß1 impairs the stress response.

Molecular cell

López-Díaz FJ, Gascard P, Balakrishnan SK, Zhao J, Del Rincon SV, Spruck C, Tlsty TD, Emerson BM

Rare somatic cells from human breast tissue exhibit extensive lineage plasticity.

Proceedings of the National Academy of Sciences of the United States of America

Roy S, Gascard P, Dumont N, Zhao J, Pan D, Petrie S, Margeta M, Tlsty TD

Breast fibroblasts modulate early dissemination, tumorigenesis, and metastasis through alteration of extracellular matrix characteristics.

Neoplasia (New York, N.Y.)

Dumont N, Liu B, Defilippis RA, Chang H, Rabban JT, Karnezis AN, Tjoe JA, Marx J, Parvin B, Tlsty TD

A physical sciences network characterization of non-tumorigenic and metastatic cells.

Scientific reports

Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH

Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes.

Breast cancer research : BCR

Fordyce CA, Patten KT, Fessenden TB, DeFilippis R, Hwang ES, Zhao J, Tlsty TD

Hello out anybody listening?

Cancer discovery

DeFilippis RA, Tlsty TD

Conceptualizing a tool to optimize therapy based on dynamic heterogeneity.

Physical biology

Liao D, Estévez-Salmerón L, Tlsty TD

Generalized principles of stochasticity can be used to control dynamic heterogeneity.

Physical biology

Liao D, Estévez-Salmerón L, Tlsty TD

CD36 repression activates a multicellular stromal program shared by high mammographic density and tumor tissues.

Cancer discovery

DeFilippis RA, Chang H, Dumont N, Rabban JT, Chen YY, Fontenay GV, Berman HK, Gauthier ML, Zhao J, Hu D, Marx JJ, Tjoe JA, Ziv E, Febbraio M, Kerlikowske K, Parvin B, Tlsty TD

The clonal and mutational evolution spectrum of primary triple-negative breast cancers.


Shah SP, Roth A, Goya R, Oloumi A, Ha G, Zhao Y, Turashvili G, Ding J, Tse K, Haffari G, Bashashati A, Prentice LM, Khattra J, Burleigh A, Yap D, Bernard V, McPherson A, Shumansky K, Crisan A, Giuliany R, Heravi-Moussavi A, Rosner J, Lai D, Birol I, Varhol R, Tam A, Dhalla N, Zeng T, Ma K, Chan SK, Griffith M, Moradian A, Cheng SW, Morin GB, Watson P, Gelmon K, Chia S, Chin SF, Curtis C, Rueda OM, Pharoah PD, Damaraju S, Mackey J, Hoon K, Harkins T, Tadigotla V, Sigaroudinia M, Gascard P, Tlsty T, Costello JF, Meyer IM, Eaves CJ, Wasserman WW, Jones S, Huntsman D, Hirst M, Caldas C, Marra MA, Aparicio S

p16(INK4a) expression and breast cancer risk in women with atypical hyperplasia.

Cancer prevention research (Philadelphia, Pa.)

Radisky DC, Santisteban M, Berman HK, Gauthier ML, Frost MH, Reynolds CA, Vierkant RA, Pankratz VS, Visscher DW, Tlsty TD, Hartmann LC

An analogy between the evolution of drug resistance in bacterial communities and malignant tissues.

Nature reviews. Cancer

Lambert G, Estévez-Salmeron L, Oh S, Liao D, Emerson BM, Tlsty TD, Austin RH

Tumor microenvironment and progression.

Journal of surgical oncology

Dvorak HF, Weaver VM, Tlsty TD, Bergers G

A twist of cell fate.

Cell stem cell

Tlsty TD

Biomarker expression and risk of subsequent tumors after initial ductal carcinoma in situ diagnosis.

Journal of the National Cancer Institute

Kerlikowske K, Molinaro AM, Gauthier ML, Berman HK, Waldman F, Bennington J, Sanchez H, Jimenez C, Stewart K, Chew K, Ljung BM, Tlsty TD

Primary cilia regulate branching morphogenesis during mammary gland development.

Current biology : CB

McDermott KM, Liu BY, Tlsty TD, Pazour GJ

Unprecedented opportunities and promise for cancer prevention research.

Cancer prevention research (Philadelphia, Pa.)

Blackburn EH, Tlsty TD, Lippman SM

DNA damage drives an activin a-dependent induction of cyclooxygenase-2 in premalignant cells and lesions.

Cancer prevention research (Philadelphia, Pa.)

Fordyce C, Fessenden T, Pickering C, Jung J, Singla V, Berman H, Tlsty T

Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy.

Breast cancer research : BCR

Dumont N, Crawford YG, Sigaroudinia M, Nagrani SS, Wilson MB, Buehring GC, Turashvili G, Aparicio S, Gauthier ML, Fordyce CA, McDermott KM, Tlsty TD

Reflections on miR-ing effects in metastasis.

Cancer cell

Dumont N, Tlsty TD

Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers.

Proceedings of the National Academy of Sciences of the United States of America

Dumont N, Wilson MB, Crawford YG, Reynolds PA, Sigaroudinia M, Tlsty TD

Graphical methods for quantifying macromolecules through bright field imaging.

Bioinformatics (Oxford, England)

Chang H, DeFilippis RA, Tlsty TD, Parvin B

Morphologically normal-appearing mammary epithelial cells obtained from high-risk women exhibit methylation silencing of INK4a/ARF.

Clinical cancer research : an official journal of the American Association for Cancer Research

Bean GR, Bryson AD, Pilie PG, Goldenberg V, Baker JC, Ibarra C, Brander DM, Paisie C, Case NR, Gauthier M, Reynolds PA, Dietze E, Ostrander J, Scott V, Wilke LG, Yee L, Kimler BF, Fabian CJ, Zalles CM, Broadwater G, Tlsty TD, Seewaldt VL

Abrogated response to cellular stress identifies DCIS associated with subsequent tumor events and defines basal-like breast tumors.

Cancer cell

Gauthier ML, Berman HK, Miller C, Kozakeiwicz K, Chew K, Moore D, Rabban J, Chen YY, Kerlikowske K, Tlsty TD

Stratification of breast cancer risk in women with atypia: a Mayo cohort study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Degnim AC, Visscher DW, Berman HK, Frost MH, Sellers TA, Vierkant RA, Maloney SD, Pankratz VS, de Groen PC, Lingle WL, Ghosh K, Penheiter L, Tlsty T, Melton LJ, Reynolds CA, Hartmann LC

Luminal cells GATA have it.

Nature cell biology

Tlsty TD

p16INK4a modulates p53 in primary human mammary epithelial cells.

Cancer research

Zhang J, Pickering CR, Holst CR, Gauthier ML, Tlsty TD

Simulating properties of in vitro epithelial cell morphogenesis.

PLoS computational biology

Grant MR, Mostov KE, Tlsty TD, Hunt CA

Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells.

The Journal of biological chemistry

Reynolds PA, Sigaroudinia M, Zardo G, Wilson MB, Benton GM, Miller CJ, Hong C, Fridlyand J, Costello JF, Tlsty TD

p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells.

PLoS biology

McDermott KM, Zhang J, Holst CR, Kozakiewicz BK, Singla V, Tlsty TD

Tumor stroma and regulation of cancer development.

Annual review of pathology

Tlsty TD, Coussens LM

Benign breast disease and the risk of breast cancer.

The New England journal of medicine

Hartmann LC, Sellers TA, Frost MH, Lingle WL, Degnim AC, Ghosh K, Vierkant RA, Maloney SD, Pankratz VS, Hillman DW, Suman VJ, Johnson J, Blake C, Tlsty T, Vachon CM, Melton LJ, Visscher DW

p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue.

Cancer research

Gauthier ML, Pickering CR, Miller CJ, Fordyce CA, Chew KL, Berman HK, Tlsty TD

Genetic and epigenetic changes in mammary epithelial cells identify a subpopulation of cells involved in early carcinogenesis.

Cold Spring Harbor symposia on quantitative biology

Berman H, Zhang J, Crawford YG, Gauthier ML, Fordyce CA, McDermott KM, Sigaroudinia M, Kozakiewicz K, Tlsty TD

Genetic and epigenetic changes in mammary epithelial cells may mimic early events in carcinogenesis.

Journal of mammary gland biology and neoplasia

Tlsty TD, Crawford YG, Holst CR, Fordyce CA, Zhang J, McDermott K, Kozakiewicz K, Gauthier ML

Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program.

Cancer cell

Crawford YG, Gauthier ML, Joubel A, Mantei K, Kozakiewicz K, Afshari CA, Tlsty TD

Cyclooxygenase-2 expression is related to nuclear grade in ductal carcinoma in situ and is increased in its normal adjacent epithelium.

Cancer research

Shim V, Gauthier ML, Sudilovsky D, Mantei K, Chew KL, Moore DH, Cha I, Tlsty TD, Esserman LJ

Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia.

Cancer research

Holst CR, Nuovo GJ, Esteller M, Chew K, Baylin SB, Herman JG, Tlsty TD

Induction of tubulogenesis in telomerase-immortalized human microvascular endothelial cells by glioblastoma cells.

Experimental cell research

Venetsanakos E, Mirza A, Fanton C, Romanov SR, Tlsty T, McMahon M

Minichromosome maintenance protein 2 expression in prostate: characterization and association with outcome after therapy for cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Meng MV, Grossfeld GD, Williams GH, Dilworth S, Stoeber K, Mulley TW, Weinberg V, Carroll PR, Tlsty TD

DNA replication licensing and human cell proliferation.

Journal of cell science

Stoeber K, Tlsty TD, Happerfield L, Thomas GA, Romanov S, Bobrow L, Williams ED, Williams GH

Loss of chromosomal integrity in human mammary epithelial cells subsequent to escape from senescence.

Journal of mammary gland biology and neoplasia

Tlsty TD, Romanov SR, Kozakiewicz BK, Holst CR, Haupt LM, Crawford YG

Stromal cells can contribute oncogenic signals.

Seminars in cancer biology

Tlsty TD

Know thy neighbor: stromal cells can contribute oncogenic signals.

Current opinion in genetics & development

Tlsty TD, Hein PW

Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes.


Romanov SR, Kozakiewicz BK, Holst CR, Stampfer MR, Haupt LM, Tlsty TD

Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts.

Proceedings of the National Academy of Sciences of the United States of America

Felsher DW, Zetterberg A, Zhu J, Tlsty T, Bishop JM

Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium.

Cancer research

Olumi AF, Grossfeld GD, Hayward SW, Carroll PR, Tlsty TD, Cunha GR

Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype.

Nature genetics

Jiang XR, Jimenez G, Chang E, Frolkis M, Kusler B, Sage M, Beeche M, Bodnar AG, Wahl GM, Tlsty TD, Chiu CP

Attenuation of G1 checkpoint function by the non-genotoxic carcinogen phenobarbital.


Gonzales AJ, Christensen JG, Preston RJ, Goldsworthy TL, Tlsty TD, Fox TR

Genetic and epigenetic influences in prostatic carcinogenesis (review).

International journal of oncology

Hayward SW, Grossfeld GD, Tlsty TD, Cunha GR

An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control.

Proceedings of the National Academy of Sciences of the United States of America

Gualberto A, Aldape K, Kozakiewicz K, Tlsty TD

Identification of additional complementation groups that regulate genomic instability.

Genes, chromosomes & cancer

Hall IJ, Gioeli D, Weissman BE, Tlsty TD

Cellular adhesion regulates p53 protein levels in primary human keratinocytes.

Cancer research

Nigro JM, Aldape KD, Hess SM, Tlsty TD

Genomic instability and its role in neoplasia.

Current topics in microbiology and immunology

Tlsty TD

Separate pathways for p53 induction by ionizing radiation and N-(phosphonoacetyl)-L-aspartate.

Cancer research

Chen CY, Hall I, Lansing TJ, Gilmer TM, Tlsty TD, Kastan MB

Alteration of cell cycle kinase complexes in human papillomavirus E6- and E7-expressing fibroblasts precedes neoplastic transformation.

Journal of virology

Xiong Y, Kuppuswamy D, Li Y, Livanos EM, Hixon M, White A, Beach D, Tlsty TD

Genomic instability and cancer.

Mutation research

Tlsty TD, Briot A, Gualberto A, Hall I, Hess S, Hixon M, Kuppuswamy D, Romanov S, Sage M, White A

Defective G2 checkpoint function in cells from individuals with familial cancer syndromes.

Cancer research

Paules RS, Levedakou EN, Wilson SJ, Innes CL, Rhodes N, Tlsty TD, Galloway DA, Donehower LA, Tainsky MA, Kaufmann WK

Analysis of cell cycle checkpoint status in mammalian cells.

Methods in enzymology

Tlsty T, Briot A, Poulose B

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.


Dulic V, Kaufmann WK, Wilson SJ, Tlsty TD, Lees E, Harper JW, Elledge SJ, Reed SI

Genomic integrity and the genetics of cancer.

Cold Spring Harbor symposia on quantitative biology

Tlsty TD, White A, Livanos E, Sage M, Roelofs H, Briot A, Poulose B

Loss of chromosomal integrity in neoplasia.

Cold Spring Harbor symposia on quantitative biology

Tlsty TD, Jonczyk P, White A, Sage M, Hall I, Schaefer D, Briot A, Livanos E, Roelofs H, Poulose B

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53.


Livingstone LR, White A, Sprouse J, Livanos E, Jacks T, Tlsty TD

Suppression of gene amplification in human cell hybrids.

Science (New York, N.Y.)

Tlsty TD, White A, Sanchez J

Normal diploid human and rodent cells lack a detectable frequency of gene amplification.

Proceedings of the National Academy of Sciences of the United States of America

Tlsty TD

Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbrück fluctuation analysis.

Proceedings of the National Academy of Sciences of the United States of America

Tlsty TD, Margolin BH, Lum K

Rapid emergence of methotrexate resistance in cultured mouse cells.

Cancer research

Rath H, Tlsty T, Schimke RT

Gene amplification in the lac region of E. coli.


Tlsty TD, Albertini AM, Miller JH

Analysis of spontaneous deletions and gene amplification in the lac region of Escherichia coli.

Cold Spring Harbor symposia on quantitative biology

Albertini AM, Hofer M, Calos MP, Tlsty TD, Miller JH

Insertion, excision, and inversion of Tn5.

Cold Spring Harbor symposia on quantitative biology

Berg DE, Egner C, Hirschel BJ, Howard J, Johnsrud L, Jorgensen RA, Tlsty TD