Sophie Dumont, PhD

Professor
Bioengineering
[email protected]
+1 415 502-1229
Publications: 

Structural and functional insights into activation and regulation of the dynein-dynactin-NuMA complex.

bioRxiv : the preprint server for biology

Aslan M, d'Amico EA, Cho NH, Taheri A, Zhao Y, Zhong X, Blaauw M, Carter AP, Dumont S, Yildiz A

Torques within and outside the human spindle balance twist at anaphase.

The Journal of cell biology

Neahring L, Cho NH, He Y, Liu G, Fernandes J, Rux CJ, Nakos K, Subramanian R, Upadhyayula S, Yildiz A, Dumont S

Chromosome size-dependent polar ejection force impairs mammalian mitotic error correction.

The Journal of cell biology

Chong MK, Rosas-Salvans M, Tran V, Dumont S

The oncogene cyclin D1 promotes bipolar spindle integrity under compressive force.

PloS one

Sutanto R, Neahring L, Serra Marques A, Jacobo Jacobo M, Kilinc S, Goga A, Dumont S

Torques within and outside the human spindle balance twist at anaphase.

bioRxiv : the preprint server for biology

Neahring L, He Y, Cho NH, Liu G, Fernandes J, Rux CJ, Nakos K, Subramanian R, Upadhyayula S, Yildiz A, Dumont S

Chromosome size-dependent polar ejection force impairs mammalian mitotic error correction.

bioRxiv : the preprint server for biology

Chong MK, Rosas-Salvans M, Tran V, Dumont S

Cytoplasmic division cycles without the nucleus and mitotic CDK/cyclin complexes.

Cell

Bakshi A, Iturra FE, Alamban A, Rosas-Salvans M, Dumont S, Aydogan MG

The oncogene cyclin D1 promotes bipolar spindle integrity under compressive force.

bioRxiv : the preprint server for biology

Sutanto R, Neahring L, Marques AS, Kilinc S, Goga A, Dumont S

Mechanisms underlying spindle assembly and robustness.

Nature reviews. Molecular cell biology

Valdez VA, Neahring L, Petry S, Dumont S

ECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells.

The EMBO journal

Kai F, Ou G, Tourdot RW, Stashko C, Gaietta G, Swift MF, Volkmann N, Long AF, Han Y, Huang HH, Northey JJ, Leidal AM, Viasnoff V, Bryant DM, Guo W, Wiita AP, Guo M, Dumont S, Hanein D, Radhakrishnan R, Weaver VM

The Astrin-SKAP complex reduces friction at the kinetochore-microtubule interface.

Current biology : CB

Rosas-Salvans M, Sutanto R, Suresh P, Dumont S

The Astrin-SKAP complex lubricates the kinetochore-microtubule interface.

Biophysical journal

Miquel R. Salvans, Renaldo Sutanto, Sophie Dumont

The mitotic protein NuMA plays a spindle-independent role in nuclear formation and mechanics.

The Journal of cell biology

Serra-Marques A, Houtekamer R, Hintzen D, Canty JT, Yildiz A, Dumont S

MYC Dysregulates Mitosis, Revealing Cancer Vulnerabilities.

Cell reports

Rohrberg J, Van de Mark D, Amouzgar M, Lee JV, Taileb M, Corella A, Kilinc S, Williams J, Jokisch ML, Camarda R, Balakrishnan S, Shankar R, Zhou A, Chang AN, Chen B, Rugo HS, Dumont S, Goga A

Abstract 1028: Extracellular matrix dimensionality reduces cellular cortical tension to stimulate pro-survival signaling in mammary epithelial cells.

Cancer research

FuiBoon Kai, Guanqing Ou, Alexandra Long, Wei Guo, Richard Tourdot, Ravi Radhakrishnan, Christopher Chen, Sophie Dumont, Valerie M. Weaver

Abstract 2902: Non-genetic TPX2/AURKA signaling facilitates tumor evolution in EGFR-TKI resistance in NSCLC.

Tumor Biology

Khyati N. Shah, Roma Bhatt, Julia Rotow, Julia Rohrberg, Victor Olivas, Victoria E. Wang, Jonathan Kuhn, Sophie Dumont, Frank Mccormick, Andrei Goga, Collin M. Blakely, Trever G. Bivona, Sourav Bandyopadhyay

Microtubule End-Clustering Maintains a Steady-State Spindle Shape.

Current biology : CB

Hueschen CL, Galstyan V, Amouzgar M, Phillips R, Dumont S

Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer.

Nature medicine

Shah KN, Bhatt R, Rotow J, Rohrberg J, Olivas V, Wang VE, Hemmati G, Martins MM, Maynard A, Kuhn J, Galeas J, Donnella HJ, Kaushik S, Ku A, Dumont S, Krings G, Haringsma HJ, Robillard L, Simmons AD, Harding TC, McCormick F, Goga A, Blakely CM, Bivona TG, Bandyopadhyay S

The Spindle: Integrating Architecture and Mechanics across Scales.

Trends in cell biology

Elting MW, Suresh P, Dumont S

Shining light on spindle positioning.

eLife

Serra-Marques A, Dumont S

NuMA recruits dynein activity to microtubule minus-ends at mitosis.

eLife

Hueschen CL, Kenny SJ, Xu K, Dumont S

The chromokinesin Klp3a and microtubules facilitate acentric chromosome segregation.

The Journal of cell biology

Karg T, Elting MW, Vicars H, Dumont S, Sullivan W

Increased lateral microtubule contact at the cell cortex is sufficient to drive mammalian spindle elongation.

Molecular biology of the cell

Guild J, Ginzberg MB, Hueschen CL, Mitchison TJ, Dumont S

Embryonic Stem Cells Cultured in Microfluidic Chambers Take Control of Their Fate by Producing Endogenous Signals Including LIF.

Stem cells (Dayton, Ohio)

Guild J, Haque A, Gheibi P, Gao Y, Son KJ, Foster E, Dumont S, Revzin A

Kinesin-5: A Team Is Just the Sum of Its Parts.

Developmental cell

Hueschen CL, Long AF, Dumont S

Emergent mechanics of biological structures.

Molecular biology of the cell

Dumont S, Prakash M

Force on spindle microtubule minus ends moves chromosomes.

The Journal of cell biology

Elting MW, Hueschen CL, Udy DB, Dumont S

4.16 Mechanical Forces in Mitosis.

Comprehensive Biophysics

S. Dumont, T.J. Mitchison

Comprehensive Biophysics

Mechanical Forces in Mitosis

Dumont S, Mitchison TJ

Force and length in the mitotic spindle.

Current biology : CB

Dumont S, Mitchison TJ

How does a millimeter-sized cell find its center?

Cell cycle (Georgetown, Tex.)

Wühr M, Dumont S, Groen AC, Needleman DJ, Mitchison TJ

Evidence for an upper limit to mitotic spindle length.

Current biology : CB

Wühr M, Chen Y, Dumont S, Groen AC, Needleman DJ, Salic A, Mitchison TJ

NS3 helicase actively separates RNA strands and senses sequence barriers ahead of the opening fork.

Proceedings of the National Academy of Sciences of the United States of America

Cheng W, Dumont S, Tinoco I, Bustamante C

RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP.

Nature

Dumont S, Cheng W, Serebrov V, Beran RK, Tinoco I, Pyle AM, Bustamante C

Identifying kinetic barriers to mechanical unfolding of the T. thermophila ribozyme.

Science (New York, N.Y.)

Onoa B, Dumont S, Liphardt J, Smith SB, Tinoco I, Bustamante C

Equilibrium information from nonequilibrium measurements in an experimental test of Jarzynski's equality.

Science (New York, N.Y.)

Liphardt J, Dumont S, Smith SB, Tinoco I, Bustamante C