Professor
P_Bioengineering
+1 415 502-1229
Publications
NuMA mechanically reinforces the spindle independently of its partner dynein.
Current biology : CB
Mechanical force locally damages, remodels and stabilizes the lattice of spindle microtubules.
bioRxiv : the preprint server for biology
SKAP binding to microtubules reduces friction at the kinetochore-microtubule interface and increases attachment stability under force.
Current biology : CB
BPS2025 - Force-dependent spindle microtubule damage, remodeling, and stabilization.
Biophysical journal
BPS2025 - NuMA mechanically reinforces spindle poles independently of dynein through self-interactions.
Biophysical journal
BPS2025 - NuMA mechanically reinforces spindle poles independently of dynein through self-interactions.
Biophysical journal
Structural and functional insights into activation and regulation of the dynein-dynactin-NuMA complex.
bioRxiv : the preprint server for biology
NuMA mechanically reinforces the spindle independently of its partner dynein.
bioRxiv : the preprint server for biology
SKAP binding to microtubules reduces friction at the kinetochore-microtubule interface and increases attachment stability under force.
bioRxiv : the preprint server for biology
Torques within and outside the human spindle balance twist at anaphase.
The Journal of cell biology
Chromosome size-dependent polar ejection force impairs mammalian mitotic error correction.
The Journal of cell biology
NuMA mechanically reinforces mammalian spindle poles independent of its partner dynein.
Biophysical journal
Probing how the Astrin-SKAP complex reduces friction at the kinetochore-microtubule interface.
Biophysical journal
Torques within and outside the human spindle balance twist at anaphase.
bioRxiv : the preprint server for biology
Chromosome size-dependent polar ejection force impairs mammalian mitotic error correction.
bioRxiv : the preprint server for biology
The oncogene cyclin D1 promotes bipolar spindle integrity under compressive force.
bioRxiv : the preprint server for biology
Mechanisms underlying spindle assembly and robustness.
Nature reviews. Molecular cell biology
ECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells.
The EMBO journal
The Astrin-SKAP complex reduces friction at the kinetochore-microtubule interface.
Current biology : CB
Connections distributed within 3 µm of chromosomes are necessary and sufficient for the kinetochore-fiber’s robust anchorage in the mammalian spindle.
Biophysical journal
The Astrin-SKAP complex lubricates the kinetochore-microtubule interface.
Biophysical journal
Opposing motors provide mechanical and functional robustness in the human spindle.
Developmental cell
Opposing Motors Provide Mechanical and Functional Robustness in the Mammalian Spindle.
Biophysical journal
Understanding the Mechanisms that Give Rise to the Mammalian Spindle's Response to Force using Theory and Microneedle Manipulation.
Biophysical journal
The mitotic protein NuMA plays a spindle-independent role in nuclear formation and mechanics.
The Journal of cell biology
Individual kinetochore-fibers locally dissipate force to maintain robust mammalian spindle structure.
The Journal of cell biology
Mammalian kinetochores count attached microtubules in a sensitive and switch-like manner.
The Journal of cell biology
Abstract 2902: Non-genetic TPX2/AURKA signaling facilitates tumor evolution in EGFR-TKI resistance in NSCLC.
Tumor Biology
The mammalian kinetochore-microtubule interface: robust mechanics and computation with many microtubules.
Current opinion in cell biology
Microtubule End-Clustering Maintains a Steady-State Spindle Shape.
Current biology : CB
Chromosome Segregation Fidelity Integrates Information across Scales.
Developmental cell
Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer.
Nature medicine
The Spindle: Integrating Architecture and Mechanics across Scales.
Trends in cell biology
Mapping Load-Bearing in the Mammalian Spindle Reveals Local Kinetochore Fiber Anchorage that Provides Mechanical Isolation and Redundancy.
Current biology : CB
Hec1 Tail Phosphorylation Differentially Regulates Mammalian Kinetochore Coupling to Polymerizing and Depolymerizing Microtubules.
Current biology : CB
Spindle assembly checkpoint satisfaction occurs via end-on but not lateral attachments under tension.
The Journal of cell biology
The chromokinesin Klp3a and microtubules facilitate acentric chromosome segregation.
The Journal of cell biology
Increased lateral microtubule contact at the cell cortex is sufficient to drive mammalian spindle elongation.
Molecular biology of the cell
Embryonic Stem Cells Cultured in Microfluidic Chambers Take Control of Their Fate by Producing Endogenous Signals Including LIF.
Stem cells (Dayton, Ohio)
Kinesin-5: A Team Is Just the Sum of Its Parts.
Developmental cell
Draft De Novo Transcriptome of the Rat Kangaroo Potorous tridactylus as a Tool for Cell Biology.
PloS one
Emergent mechanics of biological structures.
Molecular biology of the cell
Force on spindle microtubule minus ends moves chromosomes.
The Journal of cell biology
Spindle size: small droplets and a big step forward.
Current biology : CB
Imaging and physically probing kinetochores in live dividing cells.
Methods in cell biology
Deformations within moving kinetochores reveal different sites of active and passive force generation.
Science (New York, N.Y.)
4.16 Mechanical Forces in Mitosis.
Comprehensive Biophysics
Comprehensive Biophysics
Mechanical Forces in Mitosis
Chromosome segregation: spindle mechanics come to life.
Current biology : CB
Force and length in the mitotic spindle.
Current biology : CB
Compression regulates mitotic spindle length by a mechanochemical switch at the poles.
Current biology : CB
How does a millimeter-sized cell find its center?
Cell cycle (Georgetown, Tex.)
Evidence for an upper limit to mitotic spindle length.
Current biology : CB
NS3 helicase actively separates RNA strands and senses sequence barriers ahead of the opening fork.
Proceedings of the National Academy of Sciences of the United States of America
Identifying kinetic barriers to mechanical unfolding of the T. thermophila ribozyme.
Science (New York, N.Y.)