Professor In Residence
M_Neurology
The Hollenbach Lab specializes in analysis of the extremely polymorphic human leukocyte antigen (HLA) and killer immunoglobulin-like receptor (KIR) immunogenetic systems. In addition to their critical role in transplantation, over 100 infectious, autoimmune and pharmacological disease phenotypes and cancers are associated with genetic variation of HLA and KIR, which also have functional interaction with one another. Our work spans the population genetics, evolutionary history, and influence on human health of these complex genomic regions, with particular emphasis on their role in neurological disease.
Publications
Association between HLA genetics and SARS-CoV-2 infection in a large real-world cohort.
Genes and immunity
HLA variation associated with peanut allergy and anaphylaxis among non-Hispanic Black individuals.
The journal of allergy and clinical immunology. Global
Copy number variation at the complement C4 locus is associated with risk for multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England)
Human leukocyte antigen variation is associated with cytomegalovirus serostatus in healthy individuals.
American journal of human genetics
High KIR diversity in Uganda and Botswana children living with HIV.
bioRxiv : the preprint server for biology
Antigen-specificity of clonally-enriched CD8+ T cells in multiple sclerosis.
bioRxiv : the preprint server for biology
MHConstructor: a high-throughput, haplotype-informed solution to the MHC assembly challenge.
Genome biology
Multiple measures for self-identification improve matching donors with patients in unrelated hematopoietic stem cell transplant.
Communications medicine
The most frequent HLA alleles around the world: A fundamental synopsis.
Best practice & research. Clinical haematology
An autoantibody signature predictive for multiple sclerosis.
Nature medicine
High-resolution DNA methylation screening of the major histocompatibility complex in multiple sclerosis.
Frontiers in neurology
The immunogenetics of COVID-19.
Immunogenetics
Interaction between maternal killer immunoglobulin-like receptors and offspring HLAs and susceptibility of childhood ALL.
Blood advances
HLA variation and antigen presentation in COVID-19 and SARS-CoV-2 infection.
Current opinion in immunology
A short HLA-DRA isoform binds the HLA-DR2 heterodimer on the outer domain of the peptide-binding site.
Archives of biochemistry and biophysics
Minimal observed impact of HLA genotype on hospitalization and severity of SARS-CoV-2 infection.
HLA
Remarkably low KIR and HLA diversity in Amerindians reveals signatures of strong purifying selection shaping the centromeric KIR region.
Molecular biology and evolution
Approaching Genetics Through the MHC Lens: Tools and Methods for HLA Research.
Frontiers in genetics
Current HLA Investigations on SARS-CoV-2 and Perspectives.
Frontiers in genetics
Severe delayed hypersensitivity reactions to IL-1 and IL-6 inhibitors link to common HLA-DRB1*15 alleles.
Annals of the rheumatic diseases
Analysis of genomic DNA from medieval plague victims suggests long-term effect of Yersinia pestis on human immunity genes.
Molecular biology and evolution
An immunogenetic view of COVID-19.
Genetics and molecular biology
Identifying falls remotely in people with multiple sclerosis.
Journal of neurology
High-throughput Interpretation of Killer-cell Immunoglobulin-like Receptor Short-read Sequencing Data with PING.
PLoS computational biology
Following Transplantation for Acute Myelogenous Leukemia, Donor KIR Cen B02 Better Protects against Relapse than KIR Cen B01.
Journal of immunology (Baltimore, Md. : 1950)
Large-Scale Imputation of KIR Copy Number and HLA Alleles in North American and European Psoriasis Case-Control Cohorts Reveals Association of Inhibitory KIR2DL2 With Psoriasis.
Frontiers in immunology
Next-Generation Sequencing Identifies Extended HLA Class I and II Haplotypes Associated With Early-Onset and Late-Onset Myasthenia Gravis in Italian, Norwegian, and Swedish Populations.
Frontiers in immunology
High Resolution Haplotype Analyses of Classical HLA Genes in Families With Multiple Sclerosis Highlights the Role of HLA-DP Alleles in Disease Susceptibility.
Frontiers in immunology
High-Resolution Characterization of KIR Genes in a Large North American Cohort Reveals Novel Details of Structural and Sequence Diversity.
Frontiers in immunology
Behçet disease, New insights in disease associations and manifestations. A next generation sequencing study.
Clinical and experimental immunology
Single Nucleotide Polymorphism in KIR2DL1 Is Associated With HLA-C Expression in Global Populations.
Frontiers in immunology
Killer Cell Immunoglobulin-like Receptor Variants Are Associated with Protection from Symptoms Associated with More Severe Course in Parkinson Disease.
Journal of immunology (Baltimore, Md. : 1950)
KIR Variation in Iranians Combines High Haplotype and Allotype Diversity With an Abundance of Functional Inhibitory Receptors.
Frontiers in immunology
Validation of a consumer-grade activity monitor for continuous daily activity monitoring in individuals with multiple sclerosis.
Multiple sclerosis journal - experimental, translational and clinical
Next-generation sequencing reveals new information about HLA allele and haplotype diversity in a large European American population.
Human immunology
Fluctuating and Geographically Specific Selection Characterize Rapid Evolution of the Human KIR Region.
Frontiers in immunology
Silent Progression in Disease Activity-Free Relapsing Multiple Sclerosis.
Annals of neurology
A specific amino acid motif of HLA-DRB1 mediates risk and interacts with smoking history in Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America
Association of Continuous Assessment of Step Count by Remote Monitoring With Disability Progression Among Adults With Multiple Sclerosis.
JAMA network open
Conservation, Extensive Heterozygosity, and Convergence of Signaling Potential All Indicate a Critical Role for KIR3DL3 in Higher Primates.
Frontiers in immunology
Consumer (dis-)interest in Genetic Ancestry Testing: The roles of race, immigration, and ancestral certainty.
New Genetics and Society
Allele-Level KIR Genotyping of More Than a Million Samples: Workflow, Algorithm, and Observations.
Frontiers in immunology
Report from the Killer-cell Immunoglobulin-like Receptors (KIR) component of the 17th International HLA and Immunogenetics Workshop.
Human immunology
Structure-based selection of human metabolite binding P4 pocket of DRB1*15:01 and DRB1*15:03, with implications for multiple sclerosis.
Genes and immunity
Harnessing electronic medical records to advance research on multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England)
The immunogenetics of neurological disease.
Immunology
Significant variation between SNP-based HLA imputations in diverse populations: the last mile is the hardest.
The pharmacogenomics journal
Sequences of 95 human MHC haplotypes reveal extreme coding variation in genes other than highly polymorphic HLA class I and II.
Genome research
Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study.
PLoS medicine
Defining KIR and HLA Class I Genotypes at Highest Resolution via High-Throughput Sequencing.
American journal of human genetics
Association of HLA Genetic Risk Burden With Disease Phenotypes in Multiple Sclerosis.
JAMA neurology
Multidimensional reduction of multicentric cohort heterogeneity: An alternative method to increase statistical power and robustness.
Human immunology
The killer immunoglobulin-like receptor KIR3DL1 in combination with HLA-Bw4 is protective against multiple sclerosis in African Americans.
Genes and immunity
Molecular Pathology in Clinical Practice
Molecular HLA Typing
Bridging ImmunoGenomic Data Analysis Workflow Gaps (BIGDAWG): An integrated case-control analysis pipeline.
Human immunology
The GL service: Web service to exchange GL string encoded HLA & KIR genotypes with complete and accurate allele and genotype ambiguity.
Human immunology
KIR haplotypes are associated with late-onset type 1 diabetes in European-American families.
Genes and immunity
Histoimmunogenetics Markup Language 1.0: Reporting next generation sequencing-based HLA and KIR genotyping.
Human immunology
Loss and Gain of Natural Killer Cell Receptor Function in an African Hunter-Gatherer Population.
PLoS genetics
Very long haplotype tracts characterized at high resolution from HLA homozygous cell lines.
Immunogenetics
The immunogenetics of multiple sclerosis: A comprehensive review.
Journal of autoimmunity
HLA class II genotypes are not associated with age related macular degeneration in a case-control, population-based study.
Human immunology
A deep look at KIR-HLA in Amerindians: comprehensive meta-analysis reveals limited diversity of KIR haplotypes.
Human immunology
KIR diversity in Maori and Polynesians: populations in which HLA-B is not a significant KIR ligand.
Immunogenetics
Validation of statistical imputation of allele-level multilocus phased genotypes from ambiguous HLA assignments.
Tissue antigens
Genotype List String: a grammar for describing HLA and KIR genotyping results in a text string.
Tissue antigens
16(th) IHIW: immunogenomic data-management methods. report from the immunogenomic data analysis working group (IDAWG).
International journal of immunogenetics
16(th) IHIW: population global distribution of killer immunoglobulin-like receptor (KIR) and ligands.
International journal of immunogenetics
16(th) IHIW: extending the number of resources and bioinformatics analysis for the investigation of HLA rare alleles.
International journal of immunogenetics
Killer cell immunoglobulin-like receptor (KIR) gene content variation in the HGDP-CEPH populations.
Immunogenetics
A combined DPA1~DPB1 amino acid epitope is the primary unit of selection on the HLA-DP heterodimer.
Immunogenetics
Tracking human migrations by the analysis of the distribution of HLA alleles, lineages and haplotypes in closed and open populations.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Analytical methods for disease association studies with immunogenetic data.
Methods in molecular biology (Clifton, N.J.)
Analytical methods for immunogenetic population data.
Methods in molecular biology (Clifton, N.J.)
Standard methods for the management of immunogenetic data.
Methods in molecular biology (Clifton, N.J.)
Juvenile idiopathic arthritis and HLA class I and class II interactions and age-at-onset effects.
Arthritis and rheumatism
Sequence feature variant type (SFVT) analysis of the HLA genetic association in juvenile idiopathic arthritis.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Susceptibility to Crohn's disease is mediated by KIR2DL2/KIR2DL3 heterozygosity and the HLA-C ligand.
Immunogenetics
HLA class I (A, B, C) and class II (DRB1, DQA1, DQB1, DPB1) alleles and haplotypes in the Han from southern China.
Tissue antigens
Haplotype frequency estimation in patient populations: the effect of departures from Hardy-Weinberg proportions and collapsing over a locus in the HLA region.
Genetic epidemiology