Roshanak Irannejad, PhD

Asst Professor in Residence
Cardiovascular Research Inst

G protein-regulated endocytic trafficking of adenylyl cyclase type 9.


Lazar AM, Irannejad R, Baldwin TA, Sundaram AB, Gutkind JS, Inoue A, Dessauer CW, Von Zastrow M

Emerging Role of Compartmentalized G Protein-Coupled Receptor Signaling in the Cardiovascular Field.

ACS pharmacology & translational science

Plouffe B, Thomsen ARB, Irannejad R

Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies.

PLoS genetics

Yee SW, Stecula A, Chien HC, Zou L, Feofanova EV, van Borselen M, Cheung KWK, Yousri NA, Suhre K, Kinchen JM, Boerwinkle E, Irannejad R, Yu B, Giacomini KM

Genetically Encoding Quinoline Reverses Chromophore Charge and Enables Fluorescent Protein Brightening in Acidic Vesicles.

Journal of the American Chemical Society

Fu C, Kobayashi T, Wang N, Hoppmann C, Yang B, Irannejad R, Wang L

Functional selectivity of GPCR-directed drug action through location bias.

Nature chemical biology

Irannejad R, Pessino V, Mika D, Huang B, Wedegaertner PB, Conti M, von Zastrow M

The a-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the ß2-Adrenergic Receptor.

The Journal of biological chemistry

Tian X, Irannejad R, Bowman SL, Du Y, Puthenveedu MA, von Zastrow M, Benovic JL

Effects of endocytosis on receptor-mediated signaling.

Current opinion in cell biology

Irannejad R, Tsvetanova NG, Lobingier BT, von Zastrow M

G protein ß? subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway.

Molecular biology of the cell

Malik S, deRubio RG, Trembley M, Irannejad R, Wedegaertner PB, Smrcka AV

G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes.

The Journal of biological chemistry

Tsvetanova NG, Irannejad R, von Zastrow M

Investigating signaling consequences of GPCR trafficking in the endocytic pathway.

Methods in enzymology

Irannejad R, Kotowski SJ, von Zastrow M

GPCR signaling along the endocytic pathway.

Current opinion in cell biology

Irannejad R, von Zastrow M

Conformational biosensors reveal GPCR signalling from endosomes.


Irannejad R, Tomshine JC, Tomshine JR, Chevalier M, Mahoney JP, Steyaert J, Rasmussen SG, Sunahara RK, El-Samad H, Huang B, von Zastrow M

Assembly and trafficking of heterotrimeric G proteins.


Marrari Y, Crouthamel M, Irannejad R, Wedegaertner PB