Su Guo, PhD

Professor
Bioengineering
+1 415 502-4949

Dr. Guo has a broad background in molecular biology, genetics, developmental biology, neurobiology, and is interested in the molecular genetic mechanisms that regulate brain development and function. As a graduate student at Cornell University, she employed the invertebrate model organism C. elegans, and made significant contributions to the discovery of RNA interference (RNAi) as well as understanding of asymmetric cell divisions. After graduation, she became fascinated with how the brain works. As a research and postdoctoral fellow at Harvard Medical School and Genentech Inc. respectively, she carried out neurobiological studies of the development of brain neurotransmitter systems, using the vertebrate genetic model organism zebrafish. After establishing her independent research lab at the University of California, San Francisco, Dr. Guo has continued to study the molecular genetics of neural development and has expanded her research into the understanding of behavior. With her research, Dr. Guo strives to make significant contributions to our basic understanding of the brain and the mind, as well as to help treat neuropsychiatric disorders.

Publications: 

Correction to: Brain-wide perception of the emotional valence of light is regulated by distinct hypothalamic neurons.

Molecular psychiatry

Wagle M, Zarei M, Lovett-Barron M, Poston KT, Xu J, Ramey V, Pollard KS, Prober DA, Schulkin J, Deisseroth K, Guo S

Brain-wide perception of the emotional valence of light is regulated by distinct hypothalamic neurons.

Molecular psychiatry

Wagle M, Zarei M, Lovett-Barron M, Poston KT, Xu J, Ramey V, Pollard KS, Prober DA, Schulkin J, Deisseroth K, Guo S

High activity and high functional connectivity are mutually exclusive in resting state zebrafish and human brains.

BMC biology

Zarei M, Xie D, Jiang F, Bagirov A, Huang B, Raj A, Nagarajan S, Guo S

In Vivo Dopamine Neuron Imaging-Based Small Molecule Screen Identifies Novel Neuroprotective Compounds and Targets.

Frontiers in pharmacology

Kim GJ, Mo H, Liu H, Okorie M, Chen S, Zheng J, Li H, Arkin M, Huang B, Guo S

A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons.

eLife

Kim GJ, Mo H, Liu H, Wu Z, Chen S, Zheng J, Zhao X, Nucum D, Shortland J, Peng L, Elepano M, Tang B, Olson S, Paras N, Li H, Renslo AR, Arkin MR, Huang B, Lu B, Sirota M, Guo S

THC-induced behavioral stereotypy in zebrafish as a model of psychosis-like behavior.

Scientific reports

Dahlén A, Zarei M, Melgoza A, Wagle M, Guo S

Larval zebrafish display dynamic learning of aversive stimuli in a constant visual surrounding.

Learning & memory (Cold Spring Harbor, N.Y.)

Xu J, Casanave R, Guo S

Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division.

Science advances

Zhao X, Garcia JQ, Tong K, Chen X, Yang B, Li Q, Dai Z, Shi X, Seiple IB, Huang B, Guo S

Regulation of Neurogenesis in Mouse Brain by HMGB1.

Cells

Zhao X, Rouhiainen A, Li Z, Guo S, Rauvala H

Complexity of Detecting CRISPR/Cas9-Mediated Homologous Recombination in Zebrafish.

Molecular Biology

Y. Pi, K. Z. He, W. Q. Zhang, Z. Q. Dong, F. G. Jiang, K. J. Jiang, S. Guo

Heritable natural variation of light/dark preference in an outbred zebrafish population.

Journal of neurogenetics

Dahlén A, Wagle M, Zarei M, Guo S

Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite.

Cell chemical biology

Bruning JM, Wang Y, Oltrabella F, Tian B, Kholodar SA, Liu H, Bhattacharya P, Guo S, Holton JM, Fletterick RJ, Jacobson MP, England PM

A novel PRRT2 pathogenic variant in a family with paroxysmal kinesigenic dyskinesia and benign familial infantile seizures.

Cold Spring Harbor molecular case studies

Lu JG, Bishop J, Cheyette S, Zhulin IB, Guo S, Sobreira N, Brenner SE

Heritable natural variation of an anxiety-like behavior in larval zebrafish.

Journal of neurogenetics

Wagle M, Nguyen J, Lee S, Zaitlen N, Guo S

Role of the endocannabinoid system in vertebrates: Emphasis on the zebrafish model.

Development, growth & differentiation

Oltrabella F, Melgoza A, Nguyen B, Guo S

A High-Content Larval Zebrafish Brain Imaging Method for Small Molecule Drug Discovery.

PloS one

Liu H, Chen S, Huang K, Kim J, Mo H, Iovine R, Gendre J, Pascal P, Li Q, Sun Y, Dong Z, Arkin M, Guo S, Huang B

Rational design of a monomeric and photostable far-red fluorescent protein for fluorescence imaging in vivo

Protein Sci.

Yu D, Dong Z, Gustafson WC, Ruiz-González R, Signor L, Marzocca F, Borel F, Klassen MP, Makhijani K, Royant A, Jan YN, Weiss WA, Guo S, Shu X.

Open-top selective plane illumination microscope for conventionally mounted specimens.

Optics express

McGorty R, Liu H, Kamiyama D, Dong Z, Guo S, Huang B

PINK1 and Parkin control localized translation of respiratory chain component mRNAs on mitochondria outer membrane.

Cell metabolism

Gehrke S, Wu Z, Klinkenberg M, Sun Y, Auburger G, Guo S, Lu B

Heterogeneously expressed fezf2 patterns gradient Notch activity in balancing the quiescence, proliferation, and differentiation of adult neural stem cells.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Berberoglu MA, Dong Z, Li G, Zheng J, Trejo Martinez Ldel C, Peng J, Wagle M, Reichholf B, Petritsch C, Li H, Pleasure SJ, Guo S

Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells.

eLife

Sun Y, Dong Z, Jin T, Ang KH, Huang M, Haston KM, Peng J, Zhong TP, Finkbeiner S, Weiss WA, Arkin MR, Jan LY, Guo S

Understanding neurotransmitter-neuropeptide regulation through neural circuits controlling innate behaviour.

International Journal of Developmental Neuroscience

Mahendra Wagle,Su Guo

Fezf2 regulates multilineage neuronal differentiation through activating basic helix-loop-helix and homeodomain genes in the zebrafish ventral forebrain.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Yang N, Dong Z, Guo S

Genomic selection identifies vertebrate transcription factor Fezf2 binding sites and target genes.

The Journal of biological chemistry

Chen L, Zheng J, Yang N, Li H, Guo S

Conditioned place preference behavior in zebrafish.

Nature protocols

Mathur P, Lau B, Guo S

Identification of a brain center whose activity discriminates a choice behavior in zebrafish.

Proceedings of the National Academy of Sciences of the United States of America

Lau BY, Mathur P, Gould GG, Guo S

The dorsal pallium in zebrafish, Danio rerio (Cyprinidae, Teleostei).

Brain research

Mueller T, Dong Z, Berberoglu MA, Guo S

Corticotropin-releasing factor critical for zebrafish camouflage behavior is regulated by light and sensitive to ethanol.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Wagle M, Mathur P, Guo S

Preference for ethanol in zebrafish following a single exposure.

Behavioural brain research

Mathur P, Berberoglu MA, Guo S

The importance of being cis: evolution of orthologous fish and mammalian enhancer activity.

Molecular biology and evolution

Ritter DI, Li Q, Kostka D, Pollard KS, Guo S, Chuang JH

Camouflage response in zebrafish: A model for genetic dissection of molecular and cellular circuitries underlying alcoholism.

Communicative & Integrative Biology

Su Guo, Jisong Peng, Mahendra Wagle, Thomas Müller, Priya Mathur

A systematic approach to identify functional motifs within vertebrate developmental enhancers.

Developmental biology

Li Q, Ritter D, Yang N, Dong Z, Li H, Chuang JH, Guo S

Repression of RNA polymerase II elongation in vivo is critically dependent on the C-terminus of Spt5.

PloS one

Chen H, Contreras X, Yamaguchi Y, Handa H, Peterlin BM, Guo S

Ethanol-modulated camouflage response screen in zebrafish uncovers a novel role for cAMP and extracellular signal-regulated kinase signaling in behavioral sensitivity to ethanol.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Peng J, Wagle M, Mueller T, Mathur P, Lockwood BL, Bretaud S, Guo S

7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development.

Proceedings of the National Academy of Sciences of the United States of America

Barboric M, Lenasi T, Chen H, Johansen EB, Guo S, Peterlin BM

Communicative & Integrative Biology

Camouflage response in zebrafish: A model for genetic dissection of molecular and cellular circuitries underlying Alcoholism

Guo, S., Peng, J., Wagle, M., Mueller, T. and Mathur, P

cneViewer: a database of conserved non-coding elements for studies of tissue-specific gene regulation.

Bioinformatics (Oxford, England)

Persampieri J, Ritter DI, Lees D, Lehoczky J, Li Q, Guo S, Chuang JH

Biomarkers for Psychiatric Disorders

Animal models for anxiety disorders

Guo, S

Parkinson’s Disease: Pathogenic and Therapeutic Insights from Toxin and Genetic Models

Insights from zebrafish PD models, and their potential for identifying novel drug targets and therapeutic compounds

Guo, S

Patterning the zebrafish diencephalon by the conserved zinc-finger protein Fezl.

Development (Cambridge, England)

Jeong JY, Einhorn Z, Mathur P, Chen L, Lee S, Kawakami K, Guo S

A subunit of the mediator complex regulates vertebrate neuronal development.

Proceedings of the National Academy of Sciences of the United States of America

Wang X, Yang N, Uno E, Roeder RG, Guo S

Dissociation of food and opiate preference by a genetic mutation in zebrafish.

Genes, brain, and behavior

Lau B, Bretaud S, Huang Y, Lin E, Guo S

Neurogenin1 is a determinant of zebrafish basal forebrain dopaminergic neurons and is regulated by the conserved zinc finger protein Tof/Fezl.

Proceedings of the National Academy of Sciences of the United States of America

Jeong JY, Einhorn Z, Mercurio S, Lee S, Lau B, Mione M, Wilson SW, Guo S

Antipsychotics produce locomotor impairment in larval zebrafish.

Neurotoxicology and teratology

Giacomini NJ, Rose B, Kobayashi K, Guo S

Sensitivity of zebrafish to environmental toxins implicated in Parkinson's disease.

Neurotoxicology and teratology

Bretaud S, Lee S, Guo S

A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion.

Molecular microbiology

Gao LY, Guo S, McLaughlin B, Morisaki H, Engel JN, Brown EJ

Acute effects of alcohol on larval zebrafish: a genetic system for large-scale screening.

Pharmacology, biochemistry, and behavior

Lockwood B, Bjerke S, Kobayashi K, Guo S

The zebrafish forkhead transcription factor Foxi1 specifies epibranchial placode-derived sensory neurons.

Development (Cambridge, England)

Lee SA, Shen EL, Fiser A, Sali A, Guo S

A direct role of the homeodomain proteins Phox2a/2b in noradrenaline neurotransmitter identity determination.

Journal of neurochemistry

Seo H, Hong SJ, Guo S, Kim HS, Kim CH, Hwang DY, Isacson O, Rosenthal A, Kim KS

Drinks like a fish: zebra fish (Danio rerio) as a behavior genetic model to study alcohol effects.

Pharmacology, biochemistry, and behavior

Gerlai R, Lahav M, Guo S, Rosenthal A

A regulator of transcriptional elongation controls vertebrate neuronal development.

Nature

Guo S, Yamaguchi Y, Schilbach S, Wada T, Lee J, Goddard A, French D, Handa H, Rosenthal A

Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons.

Developmental biology

Guo S, Wilson SW, Cooke S, Chitnis AB, Driever W, Rosenthal A

Handbook of Molecular Genetic Techniques for Brain and Behavior Research

Mutagenesis in zebrafish: studying the brain dopamine systems

Guo, S., W. Driever, and A. Rosenthal

PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos.

Development (Cambridge, England)

Boyd L, Guo S, Levitan D, Stinchcomb DT, Kemphues KJ

par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3.

Development (Cambridge, England)

Watts JL, Etemad-Moghadam B, Guo S, Boyd L, Draper BW, Mello CC, Priess JR, Kemphues KJ

Molecular genetics of asymmetric cleavage in the early Caenorhabditis elegans embryo.

Current opinion in genetics & development

Guo S, Kemphues KJ