Abigail (Abby) Buchwalter Cool, PhD

ASST PROF IN RES-HCOMP
Cardiovascular Research Inst
[email protected]

We explore how the cell nucleus is built, specialized across cell types, and maintained over time to influence cellular identity. We are uncovering principles of nuclear organization and defining how the nucleus is disrupted by aging and disease.

Publications: 

In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response.

Science advances

Chen X, Haribowo AG, Baik AH, Fossati A, Stevenson E, Chen YR, Reyes NS, Peng T, Matthay MA, Traglia M, Pico AR, Jarosz DF, Buchwalter A, Ghaemmaghami S, Swaney DL, Jain IH

Long lifetime and tissue-specific accumulation of lamin A/C in Hutchinson-Gilford progeria syndrome.

The Journal of cell biology

Hasper J, Welle K, Swovick K, Hryhorenko J, Ghaemmaghami S, Buchwalter A

Long lifetime and selective accumulation of the A-type lamins accounts for the tissue specificity of Hutchinson-Gilford progeria syndrome.

bioRxiv : the preprint server for biology

Hasper J, Welle K, Swovick K, Hryhorenko J, Ghaemmaghami S, Buchwalter A

Coaching from the sidelines: the nuclear periphery in genome regulation.

Nature reviews. Genetics

Buchwalter A, Kaneshiro JM, Hetzer MW

Access of torsinA to the inner nuclear membrane is activity dependent and regulated in the endoplasmic reticulum.

Journal of cell science

Goodchild RE, Buchwalter AL, Naismith TV, Holbrook K, Billion K, Dauer WT, Liang CC, Dear ML, Hanson PI

Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics.

Molecular biology of the cell

Buchwalter AL, Liang Y, Hetzer MW

Static retention of the lumenal monotopic membrane protein torsinA in the endoplasmic reticulum.

The EMBO journal

Vander Heyden AB, Naismith TV, Snapp EL, Hanson PI

LULL1 retargets TorsinA to the nuclear envelope revealing an activity that is impaired by the DYT1 dystonia mutation.

Molecular biology of the cell

Vander Heyden AB, Naismith TV, Snapp EL, Hodzic D, Hanson PI

Expression of VACM-1/cul5 mutant in endothelial cells induces MAPK phosphorylation and maspin degradation and converts cells to the angiogenic phenotype.

Microvascular research

Buchwalter A, Van Dort C, Schultz S, Smith R, Le IP, Abbott JL, Oosterhouse E, Johnson AE, Hansen-Smith F, Burnatowska-Hledin M

R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism.

The Journal of biological chemistry

Drenan RM, Doupnik CA, Jayaraman M, Buchwalter AL, Kaltenbronn KM, Huettner JE, Linder ME, Blumer KJ