ADJ PROF-FY
M_Biochemistry and Biophysics
+1 415 476-2596
Publications
Contemplating the Potential of My Own Obsolescence.
GEN Biotechnology
Small molecule and cell contact-inducible systems for controlling expression and differentiation in mouse embryonic stem cells.
Development (Cambridge, England)
The Resilience Project.
GEN Biotechnology
How Did Scientists Become the Enemy?.
GEN Biotechnology
The Case for Constraints.
GEN Biotechnology
Measure for Measure.
GEN Biotechnology
Myths, Legends, and Wisdom.
GEN Biotechnology
De novo-designed minibinders expand the synthetic biology sensing repertoire.
bioRxiv : the preprint server for biology
A Coalition of the Committed.
GEN Biotechnology
Degron-Based bioPROTACs for Controlling Signaling in CAR T Cells.
ACS synthetic biology
AI as the New Medium of Creativity.
GEN Biotechnology
“Black-box” Data as a New Paradigm.
GEN Biotechnology
Degron-based bioPROTACs for controlling signaling in CAR T cells.
bioRxiv : the preprint server for biology
The Next Emergence of Synthetic Biology.
GEN Biotechnology
AI, Bias, and Discrimination.
GEN Biotechnology
Lessons from the Minimal Cell.
GEN Biotechnology
The Potential of Public–Private Partnerships for the Bioeconomy.
GEN Biotechnology
Strategic Thinking for Bold Goals.
GEN Biotechnology
Animal Alternatives for Drug Development.
GEN Biotechnology
Synthetic cytokine circuits that drive T cells into immune-excluded tumors.
Science (New York, N.Y.)
We Don't Need No Education Misinformation.
GEN Biotechnology
Mr. President, Mandate an Equitable Bioeconomy.
GEN Biotechnology
CoRa-A general approach for quantifying biological feedback control.
Proceedings of the National Academy of Sciences of the United States of America
Basic and Applied Research Are Fruits from the Same Tree.
GEN Biotechnology
The Human Right to Our Bodies.
GEN Biotechnology
Generosity of Spirit.
GEN Biotechnology
Competitive Displacement of De Novo Designed HeteroDimers Can Reversibly Control Protein–Protein Interactions and Implement Feedback in Synthetic Circuits.
GEN Biotechnology
GEN Biotechnology and the New Age of Bioinnovation.
GEN Biotechnology
The Vision for GEN Biotechnology: From Precision Biology to Engaging a Broad Audience.
GEN Biotechnology
De novo design of tyrosine and serine kinase-driven protein switches.
Nature structural & molecular biology
Director Lander, the time is now.
Science (New York, N.Y.)
Biological feedback control-Respect the loops.
Cell systems
Paralogs in the PKA Regulon Traveled Different Evolutionary Routes to Divergent Expression in Budding Yeast.
Frontiers in Fungal Biology
Sentinel cells enable genetic detection of SARS-CoV-2 Spike protein.
bioRxiv : the preprint server for biology
Stress-induced growth rate reduction restricts metabolic resource utilization to modulate osmo-adaptation time.
Cell reports
Orthogonal control of mean and variability of endogenous genes in a human cell line.
Nature communications
Multidimensional Characterization of Parts Enhances Modeling Accuracy in Genetic Circuits.
ACS synthetic biology
De novo design of protein logic gates.
Science (New York, N.Y.)
A population shift between two heritable cell types of the pathogen Candida albicans is based both on switching and selective proliferation.
Proceedings of the National Academy of Sciences of the United States of America
A Toolkit for Rapid Modular Construction of Biological Circuits in Mammalian Cells.
ACS synthetic biology
Design and Analysis of a Proportional-Integral-Derivative Controller with Biological Molecules.
Cell systems
Synthetic transcriptional synergy.
Science (New York, N.Y.)
Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs.
Nature communications
Control Theoretical Concepts for Synthetic and Systems Biology.
Current Opinion in Systems Biology
Complexity-aware simple modeling.
Current opinion in microbiology
Robust Synthetic Circuits for Two-Dimensional Control of Gene Expression in Yeast.
ACS synthetic biology
Model-guided optogenetic study of PKA signaling in budding yeast.
Molecular biology of the cell
TRADEOFFS IN ADAPTING BIOLOGICAL SYSTEMS.
European Journal of Control
The Impact of Different Sources of Fluctuations on Mutual Information in Biochemical Networks.
PLoS computational biology
Systematic analysis of asymmetric partitioning of yeast proteome between mother and daughter cells reveals "aging factors" and mechanism of lifespan asymmetry.
Proceedings of the National Academy of Sciences of the United States of America
Population diversification in a yeast metabolic program promotes anticipation of environmental shifts.
PLoS biology
A master equation and moment approach for biochemical systems with creation-time-dependent bimolecular rate functions.
The Journal of chemical physics
Delayed Ras/PKA signaling augments the unfolded protein response.
Proceedings of the National Academy of Sciences of the United States of America
Using dynamic noise propagation to infer causal regulatory relationships in biochemical networks.
ACS synthetic biology
Dynamic characterization of growth and gene expression using high-throughput automated flow cytometry.
Nature methods
Sensitivity Analysis and Model Reduction Applied to Adapting Biological Systems.
Biophysical journal
Msn2 coordinates a stoichiometric gene expression program.
Current biology : CB
Building robust functionality in synthetic circuits using engineered feedback regulation.
Current opinion in biotechnology
Formation of subnuclear foci is a unique spatial behavior of mating MAPKs during hyperosmotic stress.
Cell reports
Synergistic dual positive feedback loops established by molecular sequestration generate robust bimodal response.
Proceedings of the National Academy of Sciences of the United States of America
Basic leucine zipper transcription factor Hac1 binds DNA in two distinct modes as revealed by microfluidic analyses.
Proceedings of the National Academy of Sciences of the United States of America
Towards a minimal stochastic model for a large class of diffusion-reactions on biological membranes.
The Journal of chemical physics
Modeling and simulation of cellular functions.
Molecular biology of the cell
Stochastic modeling of cellular networks.
Methods in cell biology
A data-integrated method for analyzing stochastic biochemical networks.
The Journal of chemical physics
Genetics: Noise rules.
Nature
In silico feedback for in vivo regulation of a gene expression circuit.
Nature biotechnology
Can a systems perspective help us appreciate the biological meaning of small effects?
Developmental cell
Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity.
The Journal of cell biology
Homeostatic Regulation of the Unfolded Protein Response.
Biophysical journal
Coordinate control of gene expression noise and interchromosomal interactions in a MAP kinase pathway.
Nature cell biology
Combinatorial, site-specific requirement for heterochromatic silencing factors in the elimination of nucleosome-free regions.
Genes & development
BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response.
PLoS biology
Defining network topologies that can achieve biochemical adaptation.
The FASEB Journal
Discriminating between rival biochemical network models: three approaches to optimal experiment design.
BMC systems biology
Modelling and analysis of gene regulatory network using feedback control theory.
International Journal of Systems Science
Not all quiet on the noise front.
Nature chemical biology
A rigorous framework for multiscale simulation of stochastic cellular networks.
The Journal of chemical physics
Tuning the activation threshold of a kinase network by nested feedback loops.
Science (New York, N.Y.)
Bound attractant at the leading vs. the trailing edge determines chemotactic prowess.
Proceedings of the National Academy of Sciences of the United States of America
9. Digital Filter Stepsize Control in DASPK and Its Effect on Control Optimization Performance.
Real-Time PDE-Constrained Optimization
Module-based analysis of robustness tradeoffs in the heat shock response system.
PLoS computational biology
Advanced Methods and Algorithms for Biological Networks Analysis.
Proceedings of the IEEE
Regulated degradation is a mechanism for suppressing stochastic fluctuations in gene regulatory networks.
Biophysical journal
Surviving heat shock: control strategies for robustness and performance.
Proceedings of the National Academy of Sciences of the United States of America
Module-Based Analysis of Robustness Tradeoffs in the Heat Shock Response System.
PLoS computational biology
Systems biology: from physiology to gene regulation.
IEEE Control Systems Magazine
Feedback Regulation of the Heat Shock Response in E. coli.
Multidisciplinary Research in Control
Calcium homeostasis and parturient hypocalcemia: an integral feedback perspective.
Journal of theoretical biology