People

Katerina Akasoglou, PhD

Professor In Residence
Neurology

Dr. Akassoglou has pioneered studies in the investigation of neurovascular and neuroimmune mechanisms in neurologic diseases, and in particular the role of the blood clotting factors in CNS autoimmunity, trauma, and neurodegeneration. Her aim is to understand the mechanisms that control the communication between the brain, immune and vascular systems with the ultimate goal to design novel therapies for neurologic diseases—and in particular, multiple sclerosis and neurodegenerative diseases.

Rosemary Akhurst, PhD

Professor In Residence
HDF Comprehensive Cancer Ctr

TGFβ signaling is important in cancer, vascular, and stem cell biology, as well as tumor drug-resistance and immunotherapy. We study how TGFβ regulates these processes in vivo, and how genetic variation affects TGFβ related diseases and drug outcomes.

Akhurst Lab

Tamara Alliston, PhD

Professor
Orthopaedic Surgery

Our research focuses on the mechanobiologic pathways controlling stem cell and skeletal cell differentiation in bone and cartilage. We seek to understand how these pathways maintain the mechanical integrity of the healthy skeleton, and how this is disrupted in skeletal diseases like arthritis and osteoporosis.

Michelle Arkin, PhD

Department Chair and Professor
Pharmaceutical Chemistry

Michelle’s lab develops innovative approaches to screen for chemical tools and drug leads, using biophysical approaches like fragment-based drug discovery and biological approaches including high-content imaging with primary cells and organisms. Our goal is to demonstrate ‘druggability’ of new target classes and to use our compounds to discover new targets for drug discovery. Areas of interest include protein-protein interactions, allosteric and scaffolding sites in enzymes, and orphan and neglected diseases.

Diane Barber, PhD

Professor and Chair
Cell and Tissue Biology

Mary Helen Barcellos-Hoff, PhD

Professor
Radiation Oncology

The Barcellos-Hoff laboratory studies radiation carcinogenesis and biologically augmented radiotherapy. In studies funded by DOE and NASA, she describe the complexity of radiation effects on biological systems and identified new mechanisms underlying radiation carcinogenesis. Translational research based on aspects of these low dose radiation studies provided new insights into the role of transforming growth factor beta (TGFß) in genomic stability and the DNA damage response and a rationale for implementing TGFß inhibition during radiotherapy.

Aditi Bhargava, PhD

Recall Professor
Ob/Gyn, Reproductive Sciences

The incidence of stress-related illnesses like irritable bowel syndrome and inflammatory bowel disease (IBD), have surged in the past few decades. The underlying cause of these and other stress-related diseases involves a complex interaction between genes and environment. In response to a stressor, a plethora of genes are rapidly turned "on" (activated) or "off" (repressed).

Xin Chen, PhD

Professor Emeritus
Bioengineering

My lab studies molecular genetics and signaling pathways during hepatic carcinogenesis. Specifically, using genomic approaches including expression arrays and array based CGH, we have identified large numbers of genes which are deregulated during liver cancer development. Using murine models, we are studying how these genetic alterations contribute to malignant transformation and progression in vivo. Our current studies focus on AKT/mTOR and Notch pathways and how they regulate cancer metabolism and cancer cell proliferation.

Seemay Chou, PhD

Assistant Professor
Biochemistry and Biophysics

Seemay Chou is in the Department of Biochemistry and Biophysics. Her lab investigates the mechanisms by which bacteria interact with specific organisms, including other microbes and tick disease vectors by which they can be transmitted to humans.

Abigail (Abby) Buchwalter Cool, PhD

ASST PROF IN RES-HCOMP
Cardiovascular Research Inst

We explore how the cell nucleus is built, specialized across cell types, and maintained over time to influence cellular identity. We are uncovering principles of nuclear organization and defining how the nucleus is disrupted by aging and disease.

Tejal Desai, PhD

Professor
Bioengineering

Tejal Desai is the Deborah Cowan Endowed Professor, Department of Bioengineering & Therapeutic Sciences, Schools of Pharmacy and Medicine at University of California, San Francisco (UCSF); and Professor in Residence, Department of Bioengineering, UC Berkeley (UCB). She serves as director of the NIH training grant for the Joint UCSF/UCB Graduate Program in Bioengineering, and founding director of the UCSF/UCB Masters Program in Translational Medicine.

Dena Dubal, MD, PhD

Assoc Professor in Residence
Neurology

The goal of our research is to investigate mechanisms of longevity, resilience and neurodegenerative disease. Broadly we investigate how aging pathways can confer resilience to a brain and counter neurodegenerative diseases like Alzheimer’s. Using genetic mouse models, cell culture methods, and study of human populations using cutting-edge techniques, we study whether longevity-derived mechanisms can pave a path toward development of urgently needed therapies in aging and disease.

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