Journal of the American Chemical Society

Autophagy Receptor-Inspired Antibody-Fusion Proteins for Targeted Intracellular Degradation.

Journal of the American Chemical Society

Jiang Z, Kuo YH, Arkin MR

Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein-Protein Interaction from Nonselective Fragments.

Journal of the American Chemical Society

Konstantinidou M, Visser EJ, Vandenboorn E, Chen S, Jaishankar P, Overmans M, Dutta S, Neitz RJ, Renslo AR, Ottmann C, Brunsveld L, Arkin MR

Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6.

Journal of the American Chemical Society

Van Horn KS, Wang D, Medina-Cleghorn D, Lee PS, Bryant C, Altobelli C, Jaishankar P, Leung KK, Ng RA, Ambrose AJ, Tang Y, Arkin MR, Renslo AR

Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR? Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach.

Journal of the American Chemical Society

Somsen BA, Schellekens RJC, Verhoef CJA, Arkin MR, Ottmann C, Cossar PJ, Brunsveld L

A Single-Component Luminescent Biosensor for the SARS-CoV-2 Spike Protein.

Journal of the American Chemical Society

Ravalin M, Roh H, Suryawanshi R, Kumar GR, Pak JE, Ott M, Ting AY

Adaptor-Specific Antibody Fragment Inhibitors for the Intracellular Modulation of p97 (VCP) Protein-Protein Interactions.

Journal of the American Chemical Society

Jiang Z, Kuo YH, Zhong M, Zhang J, Zhou XX, Xing L, Wells JA, Wang Y, Arkin MR

Steric-Free Bioorthogonal Labeling of Acetylation Substrates Based on a Fluorine-Thiol Displacement Reaction.

Journal of the American Chemical Society

Lyu Z, Zhao Y, Buuh ZY, Gorman N, Goldman AR, Islam MS, Tang HY, Wang RE

Site-Directed Fragment-based Screening for the Discovery of Protein-Protein Interaction Stabilizers.

Journal of the American Chemical Society

Sijbesma E, Hallenbeck KK, Leysen S, de Vink P, Skora L, Jahnke W, Brunsveld L, Arkin MR, Ottmann C

Genetically Encoding Quinoline Reverses Chromophore Charge and Enables Fluorescent Protein Brightening in Acidic Vesicles.

Journal of the American Chemical Society

Fu C, Kobayashi T, Wang N, Hoppmann C, Yang B, Irannejad R, Wang L

miCLIP-MaPseq, a Substrate Identification Approach for Radical SAM RNA Methylating Enzymes.

Journal of the American Chemical Society

Stojkovic V, Chu T, Therizols G, Weinberg DE, Fujimori DG

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