Alzheimer's & Dementia

KLOTHO KL-VS genotype modifies the relationship between cardiorespiratory fitness and CSF biomarkers of neurodegeneration, synaptic dysfunction, and inflammation.

Alzheimer's & Dementia

Mackenzie Jarchow, Ira Driscoll, Brianne M. Breidenbach, Noah R. Cook, Catherine L. Gallagher, Sterling C. Johnson, Sanjay Asthana, Bruce P Hermann, Mark A. Sager, Kaj Blennow, Henrik Zetterberg, Cynthia M. Carlsson, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Dane B. Cook, Dena B. Dubal, Ozioma C Okonkwo

D13 caspase-6-cleaved tau, a new biomarker to complement Alzheimer’s disease diagnosis.

Alzheimer's & Dementia

Liara Rizzi, Julio C. Rojas, Andrew J. Ambrose, Marcio Luiz Figueredo Balthazar, Michelle R. Arkin, Lea T. Grinberg

Truncated tau accumulates before hyperphosphorylated tau and in relatively distinct neuronal subpopulations in entorhinal cortex and inferior temporal gyrus in Alzheimer’s disease patients.

Alzheimer's & Dementia

Ian Michael Oh, Song Hua Li, Felipe Luiz Pereira, Prabhleen Kaur, Anya Raju, Rushil Jerfy, Claudia Kimie Suemoto, Renata Elaine Paraizo Leite, Vitor Ribeiro Paes, Roberta Diehl Rodriguez, Andrew J. Ambrose, Salvatore Spina, William W. Seeley, Bruce L. Miller, Michelle R. Arkin, Lea T. Grinberg

KLOTHO KL-VS heterozygosity is associated with diminished age-related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adults.

Alzheimer's & Dementia

Ira Frahmand Driscoll, Sarah Lose, Yue Ma, Barbara B. Bendlin, Catherine Gallagher, Sterling C. Johnson, Sanjay Asthana, Bruce Hermann, Mark A. Sager, Kaj Blennow, Henrik Zetterberg, Cynthia Carlsson, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Dena Dubal, Ozioma C. Okonkwo

Relationships between KLOTHO and APOE4-associated ß-amyloid and tau alterations across AD continuum.

Alzheimer's & Dementia

Noah R. Cook, Ira Driscoll, Catherine L. Gallagher, Sterling C Johnson, Sanjay Asthana, Bruce P Hermann, Mark A. Sager, Kaj Blennow, Henrik Zetterberg, Cynthia M. Carlsson, Gwendlyn Kollmorgen, Margherita Carboni, Dan Wang, Dena B. Dubal, Ozioma Okonkwo

Klotho protein concentrations as a function of sex, APOE, family history or Alzheimer’s disease biomarker status in an at-risk cohort.

Alzheimer's & Dementia

Ira Driscoll, Tobey J Betthauser, Catherine L. Gallagher, Bruce P Hermann, Mark A. Sager, Cynthia M. Carlsson, Gwendlyn Kollmorgen, Margherita Carboni, Dan Wang, Kaj Blennow, Henrik Zetterberg, Sterling C Johnson, Sanjay Asthana, Dena B. Dubal, Ozioma Okonkwo

Transcriptomic Profiling Across Age, APOE and Sex for Models of Alzheimer’s Disease at a Single Cell Resolution.

Alzheimer's & Dementia

Yaqiao Li, Yanxia Hao, Seo Yeon Yoon, Brian Grone, Leonardo Ding, Jessica Blumenfeld, Tomiko Oskotsky, Yadong Huang, Marina Sirota

Predictive Modeling Leveraging Electronic Health Records Identifies Early Predictors of Alzheimer’s Disease.

Alzheimer's & Dementia

Alice S Tang, Katherine P Rankin, Gabriel Cerano, Silvia Miramontes, Hunter Mills, Tomiko Oskotsky, Billy Zeng, Charlotte Nelson, Karthik Soman, Sarah Woldemariam, Yaqiao Li, Albert M Lee, Zachary Miller, Isabel Elaine Allen, Stephan Sanders, Sergio Baranzini, Marina Sirota

Caspase-6-cleaved tau is relevant in Alzheimer's disease but not in 4-repeat tauopathies: Diagnostic and therapeutic implications.

Alzheimer's & Dementia

Antonia M. H. Piergies, Panos Theofilas, Song Li, Cathrine Petersen, Alexander J. Ehrenberg, Rana April Eser, Brian Chin, Teddy Yang, Shireen Khan, Raymond Ng, Salvatore Spina, William W. Seeley, Bruce L. Miller, Michelle R. Arkin, Lea T. Grinberg

Caspase inhibition mitigates tau cleavage and neurotoxicity in iPSC-induced neurons with the V337M MAPT mutation.

Alzheimer's & Dementia

Panos Theofilas, Andrew J. Ambrose, David Butler, Chao Wang, Dulce O. Morales, Cathrine Petersen, Brian Chin, Teddy Yang, Shireen Khan, Raymond Ng, Rakez Kayed, Celeste M. Karch, Bruce L. Miller, Jason E. Gestwicki, Li Gan, Sally Temple, Michelle R. Arkin, Lea T. Grinberg

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