
Professor
M_CMP (Cellular Molecular Pha)
+1 415 514-0147
The Fujimori Lab investigates fundamental biological mechanisms to understand how misregulation leads to disease. Our focus is on modifications of cellular components by small molecule chemical tags, and the roles of these modifications in biological regulation.
Publications
Identifying ligands for the PHD1 finger of KDM5A through high-throughput screening.
RSC Chemical Biology
Chemical tools targeting readers of lysine methylation.
Current opinion in chemical biology
Chromatin Sensing by the Auxiliary Domains of KDM5C Regulates Its Demethylase Activity and Is Disrupted by X-linked Intellectual Disability Mutations.
Journal of molecular biology
Editorial overview: Catalysis and regulation: The chemistry of catalysis.
Current opinion in structural biology
Catching BETs by viruses.
Biochimica et biophysica acta. Gene regulatory mechanisms
First-in-Class Allosteric Inhibitors of DNMT3A Disrupt Protein-Protein Interactions and Induce Acute Myeloid Leukemia Cell Differentiation.
Journal of medicinal chemistry
Covalent labeling of a chromatin reader domain using proximity-reactive cyclic peptides.
Chemical science
Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics.
Nature structural & molecular biology
Recognition of Histone H3 Methylation States by the PHD1 Domain of Histone Demethylase KDM5A.
ACS chemical biology
miCLIP-MaPseq Identifies Substrates of Radical SAM RNA-Methylating Enzyme Using Mechanistic Cross-Linking and Mismatch Profiling.
Methods in molecular biology (Clifton, N.J.)
Exploring the Ligand Preferences of the PHD1 Domain of Histone Demethylase KDM5A Reveals Tolerance for Modifications of the Q5 Residue of Histone 3.
ACS chemical biology
Domain cross-talk in regulation of histone modifications: Molecular mechanisms and targeting opportunities.
Current opinion in chemical biology
Dissecting contributions of catalytic and reader domains in regulation of histone demethylation.
Methods in enzymology
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.
bioRxiv : the preprint server for biology
Assessment of the nucleotide modifications in the high-resolution cryo-electron microscopy structure of the Escherichia coli 50S subunit.
Nucleic acids research
cfr(B), cfr(C), and a New cfr-Like Gene, cfr(E), in Clostridium difficile Strains Recovered across Latin America.
Antimicrobial agents and chemotherapy
Histone H3 binding to the PHD1 domain of histone demethylase KDM5A enables active site remodeling.
Nature communications
miCLIP-MaPseq, a Substrate Identification Approach for Radical SAM RNA Methylating Enzymes.
Journal of the American Chemical Society
Mutations in RNA methylating enzymes in disease.
Current opinion in chemical biology
Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme.
Nucleic acids research
Editorial overview: Chemical genetics and epigenetics.
Current opinion in chemical biology
Htm1p-Pdi1p is a folding-sensitive mannosidase that marks N-glycoproteins for ER-associated protein degradation.
Proceedings of the National Academy of Sciences of the United States of America
Opposing Chromatin Signals Direct and Regulate the Activity of Lysine Demethylase 4C (KDM4C).
The Journal of biological chemistry
Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors.
Journal of medicinal chemistry
Functional coupling between writers, erasers and readers of histone and DNA methylation.
Current opinion in structural biology
Improved Peak Detection and Deconvolution of Native Electrospray Mass Spectra from Large Protein Complexes.
Journal of the American Society for Mass Spectrometry
Radical SAM-Mediated Methylation of Ribosomal RNA.
Methods in enzymology
Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism.
Nature communications
Radical SAM-mediated methylation reactions.
Current opinion in chemical biology
Reconstitution of nucleosome demethylation and catalytic properties of a Jumonji histone demethylase.
Chemistry & biology
Site-specific and regiospecific installation of methylarginine analogues into recombinant histones and insights into effector protein binding.
Journal of the American Chemical Society
Covalent intermediate in the catalytic mechanism of the radical S-adenosyl-L-methionine methyl synthase RlmN trapped by mutagenesis.
Journal of the American Chemical Society
Protein and nucleic acid methylating enzymes: mechanisms and regulation.
Current opinion in chemical biology
The chemistry of peptidyltransferase center-targeted antibiotics: enzymatic resistance and approaches to countering resistance.
ACS chemical biology
RNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift.
Proceedings of the National Academy of Sciences of the United States of America
A novel enzymatic rearrangement.
Chemistry & biology
RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA.
Journal of the American Chemical Society
Structural analysis of an open active site conformation of nonheme iron halogenase CytC3.
Journal of the American Chemical Society
Hypoxia sensing goes gauche.
Nature chemical biology
Halogenation strategies in natural product biosynthesis.
Chemistry & biology
CD and MCD of CytC3 and taurine dioxygenase: role of the facial triad in alpha-KG-dependent oxygenases.
Journal of the American Chemical Society
Spectroscopic evidence for a high-spin Br-Fe(IV)-oxo intermediate in the alpha-ketoglutarate-dependent halogenase CytC3 from Streptomyces.
Journal of the American Chemical Society
Cloning and characterization of the biosynthetic gene cluster for kutznerides.
Proceedings of the National Academy of Sciences of the United States of America
What's new in enzymatic halogenations.
Current opinion in chemical biology
Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3.
Nature chemical biology
Enzymatic generation of the antimetabolite gamma,gamma-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete.
Chemistry & biology
Halogenation of unactivated carbon centers in natural product biosynthesis: trichlorination of leucine during barbamide biosynthesis.
Journal of the American Chemical Society
Aziridine-2-carboxylic acid-containing peptides: application to solution- and solid-phase convergent site-selective peptide modification.
Journal of the American Chemical Society
Site-selective conjugation of thiols with aziridine-2-carboxylic acid-containing peptides.
Journal of the American Chemical Society
Oligosaccharide-peptide ligation of glycosyl thiolates with dehydropeptides: synthesis of S-linked mucin-related glycopeptide conjugates.
Chemistry (Weinheim an der Bergstrasse, Germany)
Selenocysteine derivatives for chemoselective ligations.
Chembiochem : a European journal of chemical biology
J Serb Chem Soc
Model Study of Epothilone Synthesis: An Alternative Synthetic Approach to the C1-C7 fragment
Tetrahedron
Alkylation of Carbonyl Compounds in the TiCl4-promoted Reaction of Trimethylsilyl Enol Ethers with Epoxides