 
ADJ PROF-FY
      
            M_Biochemistry and Biophysics
      
            
      
            +1 415 476-2596
      Publications
Contemplating the Potential of My Own Obsolescence.
GEN Biotechnology
      
            
      
      Small molecule and cell contact-inducible systems for controlling expression and differentiation in mouse embryonic stem cells.
Development (Cambridge, England)
      
            
      
      The Resilience Project.
GEN Biotechnology
      
            
      
      How Did Scientists Become the Enemy?.
GEN Biotechnology
      
            
      
      The Case for Constraints.
GEN Biotechnology
      
            
      
      Measure for Measure.
GEN Biotechnology
      
            
      
      Myths, Legends, and Wisdom.
GEN Biotechnology
      
            
      
      De novo-designed minibinders expand the synthetic biology sensing repertoire.
bioRxiv : the preprint server for biology
      
            
      
      A Coalition of the Committed.
GEN Biotechnology
      
            
      
      Degron-Based bioPROTACs for Controlling Signaling in CAR T Cells.
ACS synthetic biology
      
            
      
      AI as the New Medium of Creativity.
GEN Biotechnology
      
            
      
      “Black-box” Data as a New Paradigm.
GEN Biotechnology
      
            
      
      Degron-based bioPROTACs for controlling signaling in CAR T cells.
bioRxiv : the preprint server for biology
      
            
      
      The Next Emergence of Synthetic Biology.
GEN Biotechnology
      
            
      
      AI, Bias, and Discrimination.
GEN Biotechnology
      
            
      
      Lessons from the Minimal Cell.
GEN Biotechnology
      
            
      
      The Potential of Public–Private Partnerships for the Bioeconomy.
GEN Biotechnology
      
            
      
      Strategic Thinking for Bold Goals.
GEN Biotechnology
      
            
      
      Animal Alternatives for Drug Development.
GEN Biotechnology
      
            
      
      Synthetic cytokine circuits that drive T cells into immune-excluded tumors.
Science (New York, N.Y.)
      
            
      
      We Don't Need No Education Misinformation.
GEN Biotechnology
      
            
      
      Mr. President, Mandate an Equitable Bioeconomy.
GEN Biotechnology
      
            
      
      CoRa-A general approach for quantifying biological feedback control.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Basic and Applied Research Are Fruits from the Same Tree.
GEN Biotechnology
      
            
      
      The Human Right to Our Bodies.
GEN Biotechnology
      
            
      
      Generosity of Spirit.
GEN Biotechnology
      
            
      
      Competitive Displacement of De Novo Designed HeteroDimers Can Reversibly Control Protein–Protein Interactions and Implement Feedback in Synthetic Circuits.
GEN Biotechnology
      
            
      
      GEN Biotechnology and the New Age of Bioinnovation.
GEN Biotechnology
      
            
      
      The Vision for GEN Biotechnology: From Precision Biology to Engaging a Broad Audience.
GEN Biotechnology
      
            
      
      De novo design of tyrosine and serine kinase-driven protein switches.
Nature structural & molecular biology
      
            
      
      Director Lander, the time is now.
Science (New York, N.Y.)
      
            
      
      Biological feedback control-Respect the loops.
Cell systems
      
            
      
      Paralogs in the PKA Regulon Traveled Different Evolutionary Routes to Divergent Expression in Budding Yeast.
Frontiers in Fungal Biology
      
            
      
      Sentinel cells enable genetic detection of SARS-CoV-2 Spike protein.
bioRxiv : the preprint server for biology
      
      Stress-induced growth rate reduction restricts metabolic resource utilization to modulate osmo-adaptation time.
Cell reports
      
            
      
      Orthogonal control of mean and variability of endogenous genes in a human cell line.
Nature communications
      
            
      
      Multidimensional Characterization of Parts Enhances Modeling Accuracy in Genetic Circuits.
ACS synthetic biology
      
            
      
      De novo design of protein logic gates.
Science (New York, N.Y.)
      
            
      
      A population shift between two heritable cell types of the pathogen Candida albicans is based both on switching and selective proliferation.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      A Toolkit for Rapid Modular Construction of Biological Circuits in Mammalian Cells.
ACS synthetic biology
      
            
      
      Design and Analysis of a Proportional-Integral-Derivative Controller with Biological Molecules.
Cell systems
      
            
      
      Synthetic transcriptional synergy.
Science (New York, N.Y.)
      
            
      
      Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs.
Nature communications
      
            
      
      Control Theoretical Concepts for Synthetic and Systems Biology.
Current Opinion in Systems Biology
      
            
      
      Complexity-aware simple modeling.
Current opinion in microbiology
      
            
      
      Robust Synthetic Circuits for Two-Dimensional Control of Gene Expression in Yeast.
ACS synthetic biology
      
            
      
      Model-guided optogenetic study of PKA signaling in budding yeast.
Molecular biology of the cell
      
            
      
      TRADEOFFS IN ADAPTING BIOLOGICAL SYSTEMS.
European Journal of Control
      
            
      
      The Impact of Different Sources of Fluctuations on Mutual Information in Biochemical Networks.
PLoS computational biology
      
            
      
      Systematic analysis of asymmetric partitioning of yeast proteome between mother and daughter cells reveals "aging factors" and mechanism of lifespan asymmetry.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Population diversification in a yeast metabolic program promotes anticipation of environmental shifts.
PLoS biology
      
            
      
      A master equation and moment approach for biochemical systems with creation-time-dependent bimolecular rate functions.
The Journal of chemical physics
      
            
      
      Delayed Ras/PKA signaling augments the unfolded protein response.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Using dynamic noise propagation to infer causal regulatory relationships in biochemical networks.
ACS synthetic biology
      
            
      
      Dynamic characterization of growth and gene expression using high-throughput automated flow cytometry.
Nature methods
      
            
      
      Sensitivity Analysis and Model Reduction Applied to Adapting Biological Systems.
Biophysical journal
      
            
      
      Msn2 coordinates a stoichiometric gene expression program.
Current biology : CB
      
            
      
      Building robust functionality in synthetic circuits using engineered feedback regulation.
Current opinion in biotechnology
      
            
      
      Formation of subnuclear foci is a unique spatial behavior of mating MAPKs during hyperosmotic stress.
Cell reports
      
            
      
      Synergistic dual positive feedback loops established by molecular sequestration generate robust bimodal response.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Basic leucine zipper transcription factor Hac1 binds DNA in two distinct modes as revealed by microfluidic analyses.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Towards a minimal stochastic model for a large class of diffusion-reactions on biological membranes.
The Journal of chemical physics
      
            
      
      Modeling and simulation of cellular functions.
Molecular biology of the cell
      
            
      
      Stochastic modeling of cellular networks.
Methods in cell biology
      
            
      
      A data-integrated method for analyzing stochastic biochemical networks.
The Journal of chemical physics
      
            
      
      Genetics: Noise rules.
Nature
      
            
      
      In silico feedback for in vivo regulation of a gene expression circuit.
Nature biotechnology
      
            
      
      Can a systems perspective help us appreciate the biological meaning of small effects?
Developmental cell
      
            
      
      Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity.
The Journal of cell biology
      
            
      
      Homeostatic Regulation of the Unfolded Protein Response.
Biophysical journal
      
            
      
      Coordinate control of gene expression noise and interchromosomal interactions in a MAP kinase pathway.
Nature cell biology
      
            
      
      Combinatorial, site-specific requirement for heterochromatic silencing factors in the elimination of nucleosome-free regions.
Genes & development
      
            
      
      BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response.
PLoS biology
      
            
      
      Defining network topologies that can achieve biochemical adaptation.
The FASEB Journal
      
            
      
      Discriminating between rival biochemical network models: three approaches to optimal experiment design.
BMC systems biology
      
            
      
      Modelling and analysis of gene regulatory network using feedback control theory.
International Journal of Systems Science
      
            
      
      Not all quiet on the noise front.
Nature chemical biology
      
            
      
      A rigorous framework for multiscale simulation of stochastic cellular networks.
The Journal of chemical physics
      
            
      
      Tuning the activation threshold of a kinase network by nested feedback loops.
Science (New York, N.Y.)
      
            
      
      Bound attractant at the leading vs. the trailing edge determines chemotactic prowess.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      9. Digital Filter Stepsize Control in DASPK and Its Effect on Control Optimization Performance.
Real-Time PDE-Constrained Optimization
      
            
      
      Module-based analysis of robustness tradeoffs in the heat shock response system.
PLoS computational biology
      
            
      
      Advanced Methods and Algorithms for Biological Networks Analysis.
Proceedings of the IEEE
      
            
      
      Regulated degradation is a mechanism for suppressing stochastic fluctuations in gene regulatory networks.
Biophysical journal
      
            
      
      Surviving heat shock: control strategies for robustness and performance.
Proceedings of the National Academy of Sciences of the United States of America
      
            
      
      Module-Based Analysis of Robustness Tradeoffs in the Heat Shock Response System.
PLoS computational biology
      
            
      
      Systems biology: from physiology to gene regulation.
IEEE Control Systems Magazine
      
            
      
      Feedback Regulation of the Heat Shock Response in E. coli.
Multidisciplinary Research in Control
      
            
      
      Calcium homeostasis and parturient hypocalcemia: an integral feedback perspective.
Journal of theoretical biology