
Professor
M_Anatomy
In our lab we study how autophagy and the lysosome regulate the response to cellular stress to promote cancer progression.
Publications
Reverse genetics rescue of sylvatic dengue viruses.
Journal of virology
Hypoxia Induces Extensive Protein and Proteolytic Remodeling of the Cell Surface in Pancreatic Adenocarcinoma (PDAC) Cell Lines.
Journal of proteome research
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins.
Science (New York, N.Y.)
Functional screen identifies RBM42 as a mediator of oncogenic mRNA translation specificity.
Nature cell biology
Leucine Aminopeptidase LyLAP enables lysosomal degradation of membrane proteins.
bioRxiv : the preprint server for biology
A multi-subunit autophagic capture complex facilitates degradation of ER stalled MHC-I in pancreatic cancer.
bioRxiv : the preprint server for biology
Functional screen for mediators of onco-mRNA translation specificity.
bioRxiv : the preprint server for biology
Ocular TB in Western Australia.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Metabolomics Tools in Antiviral Research.
Advances in Antiviral Research
G3BP1-dependent condensation of translationally inactive viral RNAs antagonizes infection.
Science advances
Pyrethroid susceptibility reversal in Aedes aegypti: A longitudinal study in Tapachula, Mexico.
PLoS neglected tropical diseases
Lysosomes as coordinators of cellular catabolism, metabolic signalling and organ physiology.
Nature reviews. Molecular cell biology
Emerging roles of the MiT/TFE factors in cancer.
Trends in cancer
Recent Reports on Bioactive Compounds from Marine Cyanobacteria in Relation to Human Health Applications.
Life (Basel, Switzerland)
High-Throughput SARS-CoV-2 Antiviral Testing Method Using the Celigo Image Cytometer.
Journal of fluorescence
The buzz in the field: the interaction between viruses, mosquitoes, and metabolism.
Frontiers in cellular and infection microbiology
RNase L activation in the cytoplasm induces aberrant processing of mRNAs in the nucleus.
PLoS pathogens
Coordinated transcriptional and catabolic programs support iron dependent adaptation to RAS-MAPK pathway inhibition in pancreatic cancer.
Cancer discovery
Electrochemical Capillary Driven Immunoassay for Detection of SARS-CoV-2.
ACS measurement science au
Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1.
Science (New York, N.Y.)
Expression of fatty acid synthase genes and their role in development and arboviral infection of Aedes aegypti.
Parasites & vectors
Risk factors for TB in Australia and their association with delayed treatment completion.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Autophagy in cancer cell remodeling and quality control.
Molecular cell
Cross-tissue and generation predictability of relative Wolbachia densities in the mosquito Aedes aegypti.
Parasites & vectors
Coupled small molecules target RNA interference and JAK/STAT signaling to reduce Zika virus infection in Aedes aegypti.
PLoS pathogens
Built to last: lysosome remodeling and repair in health and disease.
Trends in cell biology
Challenges and opportunities in 2021.
Nature cancer
Zooming in on the cell biology of disease.
Molecular biology of the cell
Autophagy in major human diseases.
The EMBO journal
SARS-CoV-2 infection triggers widespread host mRNA decay leading to an mRNA export block.
RNA (New York, N.Y.)
Permethrin resistance in Aedes aegypti: Genomic variants that confer knockdown resistance, recovery, and death.
PLoS genetics
Oncogene-regulated release of extracellular vesicles.
Developmental cell
Rapid decay of host basal mRNAs during SARS-CoV-2 infection perturbs host antiviral mRNA biogenesis and export.
bioRxiv : the preprint server for biology
Permethrin Resistance Status and Associated Mechanisms in Aedes albopictus (Diptera: Culicidae) From Chiapas, Mexico.
Journal of medical entomology
Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth.
Nature cell biology
NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C.
Developmental cell
Development of SARS-CoV-2 Nucleocapsid Specific Monoclonal Antibodies.
bioRxiv : the preprint server for biology
Resistance to commonly used insecticides and underlying mechanisms of resistance in Aedes aegypti (L.) from Sri Lanka.
Parasites & vectors
Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancer.
eLife
Metabolomic Insights into Human Arboviral Infections: Dengue, Chikungunya, and Zika Viruses.
Viruses
Host Control of Tumor Feeding: Autophagy Holds the Key.
Cell metabolism
Experimental Zika virus infection of Jamaican fruit bats (Artibeus jamaicensis) and possible entry of virus into brain via activated microglial cells.
PLoS neglected tropical diseases
MiT/TFE Family of Transcription Factors, Lysosomes, and Cancer.
Annual review of cancer biology
First report of V1016G and S989P knockdown resistant (kdr) mutations in pyrethroid-resistant Sri Lankan Aedes aegypti mosquitoes.
Parasites & vectors
Variation in competence for ZIKV transmission by Aedes aegypti and Aedes albopictus in Mexico.
PLoS neglected tropical diseases
LAMP assays of Zika virus and other infectious agents will inevitably see expanded use due to their simplicity, sensitivity, specificity, and economy.
Annals of translational medicine
Serum carcinoembryonic antigen trends for diagnosing colorectal cancer recurrence in the FACS randomized clinical trial.
The British journal of surgery
Dynamic remodeling of lipids coincides with dengue virus replication in the midgut of Aedes aegypti mosquitoes.
PLoS pathogens
[Better Reporting of Interventions: Template for Intervention Description and Replication (TIDieR) Checklist and Guide].
Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))
Extraction of unadjusted estimates of prognostic association for meta-analysis: simulation methods as good alternatives to trend and direct method estimation.
Journal of clinical epidemiology
Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth.
Science (New York, N.Y.)
Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex.
Science (New York, N.Y.)
Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance.
Cell metabolism
The Lysosome as a Regulatory Hub.
Annual review of cell and developmental biology
Metabolomics-Based Discovery of Small Molecule Biomarkers in Serum Associated with Dengue Virus Infections and Disease Outcomes.
PLoS neglected tropical diseases
[Better Reporting of Interventions: Template for Intervention Description and Replication (TIDieR) Checklist and Guide].
Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))
Pancreatic Cancer Metabolism: Breaking It Down to Build It Back Up.
Cancer discovery
YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression.
Cell reports
Circulating mycobacterial-reactive CD4+ T cells with an immunosuppressive phenotype are higher in active tuberculosis than latent tuberculosis infection.
Tuberculosis (Edinburgh, Scotland)
Stromal response to Hedgehog signaling restrains pancreatic cancer progression.
Proceedings of the National Academy of Sciences of the United States of America
CDK4/6 and IGF1 receptor inhibitors synergize to suppress the growth of p16INK4A-deficient pancreatic cancers.
Cancer research
On oncogenes and tumor suppressor genes in the mammary gland.
Cold Spring Harbor perspectives in biology
The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics.
The Journal of cell biology
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer research
Internalization, intracellular trafficking, and biodistribution of monoclonal antibody 806: a novel anti-epidermal growth factor receptor antibody.
Neoplasia (New York, N.Y.)
The efficacy of epidermal growth factor receptor-specific antibodies against glioma xenografts is influenced by receptor levels, activation status, and heterodimerization.
Clinical cancer research : an official journal of the American Association for Cancer Research
Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate.
Proceedings of the National Academy of Sciences of the United States of America
Two synaptojanin 1 isoforms are recruited to clathrin-coated pits at different stages.
Proceedings of the National Academy of Sciences of the United States of America
Treatment of human tumor xenografts with monoclonal antibody 806 in combination with a prototypical epidermal growth factor receptor-specific antibody generates enhanced antitumor activity.
Clinical cancer research : an official journal of the American Association for Cancer Research
Antitumor efficacy of cytotoxic drugs and the monoclonal antibody 806 is enhanced by the EGF receptor inhibitor AG1478.
Proceedings of the National Academy of Sciences of the United States of America
Left atrial function is unchanged by implantable defibrillator shocks on hearts in sinus rhythm.
The American journal of cardiology
Prolonged QT interval and cocaine use.
Journal of electrocardiology